Effects of Acute High Intensity Exercise Training on Cardiac Function in Type II Diabetes

NCT02998008 | Terminated

• 1 other identifier: 2016/1596
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

It is known from research that long-term exercise exposure in type 2 diabetes had positive effects. However, the effect of acute exercise in a patient group with already reduced cardiac function is not known. In this study, the impact of acute exhaustive high intensity interval training on cardiac function will be investigated in type 2 diabetes patients. One single session of exhaustive high intensity interval exercise training is expected to lead to a greater cardiac stress in diabetics than in non-diabetics, and in addition the right ventricle of the heart is expected to be more affected than the left ventricle.

Conditions

Diabetes Mellitus, Type 2

Keywords

Exercise Therapy; Heart Function Tests; Heart/physiology; Echocardiography

Outcome Measures

Primary Outcomes (1)

• echocardiography

  peak longitudinal systolic tricuspid annular velocity in cm/s

  30 minutes each measurement per subject

Study Arms (2)

Diabetes type 2 patients

OTHER

diabetes type 2 patients whose cardiac function is tested after 4x4 high intensity interval training

Behavioral: high intensity interval training

Healthy volunteers

OTHER

healthy volunteers whose cardiac function is tested after 4x4 high intensity interval training

Behavioral: high intensity interval training

Interventions

high intensity interval training BEHAVIORAL

Diabetes type 2 patients; Healthy volunteers

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Type II diabetes

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead
• St. Olavs Hospital: collaborator
• Helse Nord-Trøndelag HF: collaborator

Study Sites (1)

Department of Circulation and Medical Imaging, NTNU

Trondheim, Norway

Location

Related Publications (1)

• Ness HO, Ljones K, Gjelsvik RH, Tjonna AE, Malmo V, Nilsen HO, Hollekim-Strand SM, Dalen H, Hoydal MA. Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls. Sci Rep. 2022 May 17;12(1):8239. doi: 10.1038/s41598-022-12375-2.

  PMID: 35581305 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Øystein Risa, phd

  Norwegian University of Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2016
• First Posted: December 20, 2016
• Study Start: January 2, 2017
• Primary Completion: March 1, 2018
• Study Completion: March 1, 2018
• Last Updated: November 16, 2018

Record last verified: 2018-11

Locations

NO (1)