Barts-MINOCA Registry

NCT04440761 | Recruiting

• 1 other identifier: REDA: 130386
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI). However, the system wide availability of prompt investigation has revealed an important group of patients where progress has stalled, the diagnosis is unclear and therapeutic approaches are uncertain. Myocardial infarction with non-obstructive coronary arteries (MINOCA) is found in 1 - 13% of all patients with a clinical diagnosis of AMI. These patients present a therapeutic predicament since coronary revascularization is not appropriate. Guidelines do not exist for their management - yet the condition is not benign - the 12-month prognosis, although better than obstructive coronary artery disease patients is still guarded with recent data suggesting many questions remain unanswered.

Conditions

Myocardial Infarction; Gender; Coronary Microvascular Disease

Outcome Measures

Primary Outcomes (5)

• Mortality

  Assessment of mortality

  30 days

• Mortality

  Assessment of mortality

  1 year

• Formal diagnosis made of the cause of troponin rise

  Diagnosis

  Baseline

• Timing of diagnosis made of the cause of troponin rise

  Time to first diagnosis

  Baseline

• Questionnaire to assess change in symptoms at 2 months post-initial review in clinic/ward

  Change in symptoms assessed by Questionnaire

  2 months

Study Arms (1)

Troponin rise/ diagnosis of MINOCA

This study aims to assess, in a real-world setting, the safety, efficacy and feasibility of further investigations in patients diagnosed with MINOCA among all patients with coronary artery disease.

Other: Observation only

Interventions

Observation only OTHER

Observation only

Troponin rise/ diagnosis of MINOCA

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will include all patients admitted to or reviewed in clinic at Barts Health NHS Trust with either a diagnosis of MINOCA or who do not have a clear cause of a troponin rise. These patients range from young adults to the elderly and will include any patient ≥16 years of age. Patients who are followed up with and without any intervention (i.e. both medically managed patients as well as patients undergoing intervention) are equally as important and therefore we shall include both groups of patients. Patients will be included from referrals made by other clinicians either as in or outpatients. All these patients have their clinical data captured on a database or hospital based clinical programme.

You may qualify if:

• Both male and female patients ≥16 years of age will be included
• All patients will have a diagnosis MINOCA. Any patient who does not have a clear cause of troponin rise

You may not qualify if:

• Patients \<16 years will not be included in this study.

Sponsors & Collaborators

• Queen Mary University of London: lead

Study Sites (1)

Barts Health NHS Trust

London, United Kingdom

RECRUITING

MeSH Terms

Conditions

Myocardial Infarction; Coitus; Microvascular Angina

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Sexual Behavior; Behavior; Angina Pectoris

Study Officials

• Daniel Jones, MBBS, PhD

  Queen Mary University of London

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Daniel Jones, MBBS, PhD

CONTACT

020 7377 7000; dan.jones8@nhs.net

Krishnaraj Rathod, MBBS, PhD

CONTACT

020 7377 7000; krishnaraj.rathod1@nhs.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2020
• First Posted: June 22, 2020
• Study Start: July 1, 2020
• Primary Completion (Estimated): September 16, 2026
• Study Completion (Estimated): September 16, 2026
• Last Updated: November 18, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)