NCT04434690

Brief Summary

Many surgeons and patients prefer bilateral total knee arthroplasty (TKA) under one anesthesia as single-stage administration. A single-stage bilateral TKA can be performed in two different ways: single-stage, two-team simultaneous bilateral TKA (two surgeons bilateral TKA), and single-stage, a sequential bilateral TKA (single surgeon bilateral TKA). The purpose of this study is to evaluate the radiological results in the single-stage bilateral TKA in terms of two surgeons bilateral TKA and single surgeon bilateral TKA.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jun 2020

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2020

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

June 13, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 17, 2020

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2020

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2020

Completed
Last Updated

June 17, 2020

Status Verified

June 1, 2020

Enrollment Period

5 months

First QC Date

June 13, 2020

Last Update Submit

June 13, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Radiological examination

    Coronal and Sagittal Alignment

    14days

Study Arms (2)

Simultaneous

EXPERIMENTAL

2 surgeons will perform simultaneous total knee arthroplasty in this group.

Procedure: Simultaneous bilateral total knee arthroplasty

Single surgeon bilateral TKA group

ACTIVE COMPARATOR

One surgeon will perform sequentially tptal knee arthroplasty in this group

Procedure: Sequenced bilateral TKA

Interventions

Two surgeons bilateral TKA group

Simultaneous

Single surgeon bilateral TKA group

Single surgeon bilateral TKA group

Eligibility Criteria

Age35 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Primary bilateral knee osteoarthritis with refractory to conservative treatment Patients who accept participation in the research and the randomization

You may not qualify if:

  • no history of malignancy less than 75 years old without severe extra-articular deformities severe cardiac insufficiency and morbid obesity without systemic inflammatory diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Bezmialem Vakif University

Istanbul, Fatih, 34000, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, Resident Doctor in Orthopaedic Surgery

Study Record Dates

First Submitted

June 13, 2020

First Posted

June 17, 2020

Study Start

June 1, 2020

Primary Completion

October 30, 2020

Study Completion

October 31, 2020

Last Updated

June 17, 2020

Record last verified: 2020-06

Data Sharing

IPD Sharing
Will not share

Locations