The Effect of Exercises Performed According to Circadian Rhythm in Type 2 Diabetes
Circadian
1 other identifier
interventional
30
1 country
1
Brief Summary
Type 2 diabetes is a metabolic disease characterized by partial insulin deficiency or insulin resistance in peripheral tissue. Type 2 diabetes, which has a very high prevalence worldwide, is a socially serious health problem. Exercise has beneficial effects on the glycemic profile, such as decreased glycemic hemoglobin (HbA1c) level, increased maximum oxygen consumption (VO2max) and improved insulin sensitivity in diabetes patients. When the literature is examined, it is seen that exercise is also effective in improving metabolic health. Although the metabolic benefits of exercise have been shown, there is no study of which type of exercise is more beneficial in what time of day in individuals with Type 2 diabetes. Circadian rhythm plays an important role in clarifying this issue because the circadian rhythm is impaired in the glucose metabolism of individuals with type 2 diabetes.The aim of this study is to investigate which exercise is more effective in which time period for individuals with Type 2 diabetes
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable type-2-diabetes
Started Jun 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 8, 2020
CompletedFirst Posted
Study publicly available on registry
June 11, 2020
CompletedStudy Start
First participant enrolled
June 15, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 15, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 15, 2021
CompletedJanuary 3, 2022
December 1, 2021
1.2 years
June 8, 2020
December 30, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
HbA1c evaluation
Blood sample scores are changeable
3 hours
Fasting glucose evaluation
Blood sample are changeable
3 hours
HDL (high density lipoprotein) evaluation
Blood sample are changeable
3 hours
LDL (low density lipoprotein) evaluation
Blood sample are changeable
3 hours
Total cholesterol evaluation
Blood sample are changeable
3 hours
Circadian Rhythm Evaluation with Morningness Eveningness Questionnaire
Scores can range from 16-86. Scores of 41 and below indicate "evening types". Scores of 59 and above indicate "morning types". Scores between 42 and 58 indicate "intermediate types" in Morningness Eveningness Questionnaire
10 minutes
Secondary Outcomes (3)
6-minute walking test
10 minutes
30-second sit to stand test
10 minutes
Ferrans&Powers Quality of Life
10 minutes
Study Arms (2)
Morning Chronotype (MC) Group
EXPERIMENTALIn the MC group, exercises were applied in the morning hours for the first 6 weeks and in the evening hours for the next 6 weeks.
Evening Chronotype (EC) Group
EXPERIMENTALThe EC exercises were applied in the evening hours for the first 6 weeks and in the morning hours for the next 6 weeks
Interventions
Total of 12 weeks aerobic and strengthening exercises in different timing of the day.
Total of 12 weeks aerobic and strengthening exercises in different timing of the day.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of Type 2 diabetes
- Between the ages of 35-65
- Body mass index between 25 and 30
- HbA1c value\> 6.5%
- Fasting blood glucose\>126 mg/dl
- Inactive physical activity level
- Who independently can walk and volunteer to exercise for at least 3 days a week
You may not qualify if:
- Clinical diagnosis of Type 1 diabetes
- Clinical diagnosis of Latent Autoimmune Diabetes in Adults (LADA)
- Having diabetic Ketoacidosis coma
- Orthopedic or surgical problems to prevent walking and exercising
- Foot ulcers
- Neurologıcal, cardiac, pulmonary or systematic diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Istanbul Medipol University
Istanbul, 34820, Turkey (Türkiye)
Related Publications (2)
Savikj M, Gabriel BM, Alm PS, Smith J, Caidahl K, Bjornholm M, Fritz T, Krook A, Zierath JR, Wallberg-Henriksson H. Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial. Diabetologia. 2019 Feb;62(2):233-237. doi: 10.1007/s00125-018-4767-z. Epub 2018 Nov 13.
PMID: 30426166RESULTMenek MY, Budak M. Effect of exercises according to the circadian rhythm in type 2 diabetes: Parallel-group, single-blind, crossover study. Nutr Metab Cardiovasc Dis. 2022 Jul;32(7):1742-1752. doi: 10.1016/j.numecd.2022.04.017. Epub 2022 Apr 29.
PMID: 35606229DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer
Study Record Dates
First Submitted
June 8, 2020
First Posted
June 11, 2020
Study Start
June 15, 2020
Primary Completion
August 15, 2021
Study Completion
October 15, 2021
Last Updated
January 3, 2022
Record last verified: 2021-12
Data Sharing
- IPD Sharing
- Will not share
An article will be published at the end of this study. IIPD can be accessed with this article.