Shear Wave Elastography in Differentiating Acute or Chronic Kidney Disease
CKD-SWE
1 other identifier
observational
800
1 country
1
Brief Summary
Chronic kidney disease is a common global public health issue and its prevalence increased year by year. Early diagnosis and intervention can prevent further complications and comorbidities of long-term dialysis, cardiovascular events and mortality as well as improve the patients' life quality. To differentiate acute from chronic kidney disease was crucial especially in the setting of crowded and high-risk emergency department. To diagnose acute or chronic kidney disease, physicians usually use blood sample test combined with image studies such as conventional sonography, CT and MRI. However, there was lots of limited factors. The patients may have no previous visit records, poor renal function to receive contrast medium, or critical clinical condition to undergo time-wasting exam. Although the conventional renal sonography is accessible and inexpensive, the judgement is subjective and provide little clinical information. Recent researches of shear wave elastography in evaluating renal parenchymal stiffness showed some correlation with nephropathy. In our study, aiming to facilitating clinical implication, the investigators will use swear-wave elastography combined with conventional renal sonography to benefit patients in diagnosis of acute or chronic kidney disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2020
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2020
CompletedFirst Submitted
Initial submission to the registry
April 28, 2020
CompletedFirst Posted
Study publicly available on registry
May 27, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
November 18, 2025
October 1, 2025
6.9 years
April 28, 2020
November 16, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
To determine the correlation of kPa ratio and renal function in chronic renal disease
The analysis will be conducted to determine the correlation between kPa ratio measured by elastography and renal function in patients with chronic renal disease
change in renal function after 2 weeks
Study Arms (4)
Normal renal function
Normal renal function
Acute kidney injury in normal kidney
Acute kidney injury in normal kidney
Acute kidney injury in chronic kidney disease
Acute kidney injury in chronic kidney disease
Chronic kidney disease
Chronic kidney disease
Interventions
Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography
Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography
Record the patient's kidney size, cortical thickness, possible lesion by ordinary renal sonography as well as cortical elasticity by shear wave elastography
Eligibility Criteria
Approximately 400 patients with normal kidney function and 400 patients with abnormal kidney function
You may qualify if:
- The patients older than 20 years old who needed to receive renal sonography in emergency department of National Taiwan University Hospital.
You may not qualify if:
- The patients who didn't obtain agreement.
- The patients who can't cooperate or follow the directions
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Taiwan University Hospital
Taipei, 100, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 2 Weeks
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 28, 2020
First Posted
May 27, 2020
Study Start
February 1, 2020
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
November 18, 2025
Record last verified: 2025-10