Application of Ultrasonic Elastography in Lung Lesions
Transthoracic Ultrasound Elastography in Pulmonary Lesions and Diseases
1 other identifier
observational
45
1 country
1
Brief Summary
Elastography is an imaging of tissue elasticity or stiffness and is currently emerging as a mainstream tool for ultrasound-based diagnosis. This compressibility property of materials, mathematically expressed as the change in tissue displacement as a function of its distance from the compressing device, is known as strain and is the parameter that is imaged in an elastogram. Elastography has currently shown promising result in differentiating viscoelastic nature of various organs, which is a consequence of certain underlying diseases. At present, there are limited literatures revealing the application and feasibility of ultrasonic elastography in lung lesions. This is essentially important as it may serve as an adjuvant to B-mode ultrasound. The investigators aimed at exploring the application and feasibility of ultrasonic elastography on lung lesions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Dec 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
November 24, 2015
CompletedFirst Posted
Study publicly available on registry
December 22, 2015
CompletedDecember 22, 2015
December 1, 2015
1.2 years
November 24, 2015
December 17, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Comparison of strain ratio between necrosis, atelectasis, consolidation and tumor
The strain ratio was measured under ultrasonic elastography. At least three measurements were performed each time and we average all the measurements as the final strain ratio. Independent t test was used for comparison.
Up to 15 months
Eligibility Criteria
Patients with radiographic findings of consolidation, obstructive pneumonitis or tumors, detected on chest computed tomography (CT), who received ultrasound study with or without ultrasound-guided biopsy for tissue proof and UE, from December 2011 to March 2013.
You may qualify if:
- Patients with radiographic findings of:
- consolidation
- obstructive pneumonitis
- tumors
You may not qualify if:
- Patients with poor acoustic window
- Unable to hold breathing
- Not cooperative
- Presence of pleural effusion
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Taiwan University Hospital
Taipei, Taipei City, 100, Taiwan
Related Publications (1)
Lim CK, Chung CL, Lin YT, Chang CH, Lai YC, Wang HC, Yu CJ. Transthoracic Ultrasound Elastography in Pulmonary Lesions and Diseases. Ultrasound Med Biol. 2017 Jan;43(1):145-152. doi: 10.1016/j.ultrasmedbio.2016.08.028. Epub 2016 Oct 12.
PMID: 27743728DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Hao-Chien Wang, MD, PhD
National Taiwan University Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 24, 2015
First Posted
December 22, 2015
Study Start
December 1, 2011
Primary Completion
March 1, 2013
Study Completion
March 1, 2013
Last Updated
December 22, 2015
Record last verified: 2015-12