Effect of Processed Blueberry on Blood Glucose and Antioxidant Status in Human Adults

NCT04396262 | Completed DMC

• 2 other identifiers: 2019-2042015-102
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Canada's Food Guide (2007) recommended 7-10 servings of fruits and vegetables per day for a normal adult population. Although fruit juice (125 ml) is considered as one serving of fruits, the consumption of some fruit juices may be limited due to their high amount of sugar. The consumption of sugary drinks can lead to a rapid rise in postprandial glycaemia. Wild blueberries, due to their high level of anthocyanins, may provide multiple health benefits including improved blood glucose control, however, the consumption of fresh berries is limited by their short seasonal availability. Hydro-Thermodynamic (HTD) processing of blueberries allows the processing of whole berries including their skin and seeds into a beverage with the amount of anthocyanins comparable with fresh berries. The objective of the study is to investigate the effect of HTD-processed blueberries on postprandial glycaemia and antioxidant activity.

Conditions

Blood Glucose

Keywords

Blueberry; Blood Glucose; Antioxidants; Hydro-Thermodynamic Processing; Beverages

Outcome Measures

Primary Outcomes (1)

• Blood glucose

  The concentration of glucose in venous blood after consuming HTD-blueberry beverage with white bread or water control with white bread.

  0-120 min

Secondary Outcomes (1)

• Postprandial antioxidant activity in blood

  0-120 min

Study Arms (2)

HTD-blueberry beverage with white bread

EXPERIMENTAL

The beverage prepared using hydro-thermodynamic processing of whole wild blueberries.

Other: Food-1

Sweetened water (control) with white bread

EXPERIMENTAL

The water control of the same volume and with the same amount of available carbohydrate as HTD-blueberry beverage.

Other: Food-2

Interventions

Food-1 OTHER

HTD-blueberry beverage with white bread.

HTD-blueberry beverage with white bread

Food-2 OTHER

Sweetened water with white bread as a control.

Sweetened water (control) with white bread

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults
• Body mass index (BMI) within normal range (18.5-24.9 kg/m2 for adults)

You may not qualify if:

• Chronic metabolic diseases or inflammatory conditions
• Smokers
• A medication that influences glucose control or gastrointestinal function
• Known allergies
• Intellectual disabilities

Sponsors & Collaborators

• Mount Saint Vincent University: lead

Study Sites (1)

Mount Saint Vincent University

Halifax, Nova Scotia, B3M 2J6, Canada

Location

Study Officials

• Bohdan Luhovyy, PhD

  Mount Saint Vincent University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2020
• First Posted: May 20, 2020
• Study Start: November 1, 2015
• Primary Completion: August 31, 2016
• Study Completion: August 31, 2022
• Last Updated: March 20, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)