Resting Energy Expenditure of the COronaVirus (COVID19) Patient in Reanimation Context

NCT04391686 | Completed

• 1 other identifier: 2020-04
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Compare the resting energy expenditure of COVID-19 patients (obese or non-obese) in intensive care unit with mechanical ventilation to a control group of non-COVID-19 intensive care patients.

Conditions

COVID-19; Obesity

Keywords

resting energy expenditure; artificial nutrition

Outcome Measures

Primary Outcomes (1)

• The resting energy expenditure (in Kcal / 24h) measured by indirect calorimetry during the stay in intensive care.

  baseline and 3 months later

Study Arms (3)

COVID intensive care unit

Diagnostic Test: indirect calorimetry

intensive care unit

Diagnostic Test: indirect calorimetry

obesity

Diagnostic Test: indirect calorimetry

Interventions

indirect calorimetry DIAGNOSTIC_TEST

to determine and compare the resting energy expenditure of each group

COVID intensive care unit; intensive care unit; obesity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to resuscitation under mechanical ventilation and who have benefited from a first indirect calorimetry measurement via COSMED Q NRG within 48 hours after their admission are identified by the physicians of the resuscitation department. If these patients meet all the inclusion criteria, they will be notified to the center's investigators so that the latter can take the necessary steps to inform the patient or the confidential person about the study.

You may qualify if:

• Age ≥ 18 years;
• Patient followed in the nutrition service;
• Patient who benefited from an indirect calorimetry whatever the indication between 01/01/20 and 31/12/2020;
• BMI\> 30.
• Age ≥ 18 years;
• Patient having undergone a resuscitation stay
• Patient on mechanical ventilation (intubated or tracheotomized) during their stay in intensive care;
• Patient having benefited from an indirect calorimetry upon arrival in intensive care;
• Only for the COVID Group:
• Patient hospitalized in intensive care for COVID 19 infection diagnosed by a positive PCR via nasopharyngeal sampling or endotracheal aspiration.
• Patient who has not yet carried out his post-resuscitation visit;
• Only for the Resuscitation Control Group:
• \- Patient hospitalized in intensive care for an indication other than an infectious cause.

You may not qualify if:

• Person deprived of liberty;
• Person subject to legal protection measures;
• Patient's opposition to participate in research.
• For patients intubated during the resuscitation stay Fi02\> 70% which does not allow a correct interpretation of the calorimetry;
• Pregnancy ;
• Person deprived of liberty;
• Person subject to legal protection measures;
• Opposition of the patient or the person of trust to participate in the research.
• Only for the COVID Group:
• Contraindication to indirect calorimetry (claustrophobia for post-resuscitation patients where calorimetry is performed with a mask);
• Contraindication to bioimpedancemetry (electronic implants, limb amputation, weight \<30kg or\> 300kg);

Sponsors & Collaborators

• Centre Hospitalier Arras: lead

Study Sites (1)

Arras general hospital

Arras, 62000, France

Location

MeSH Terms

Conditions

COVID-19; Obesity

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Vincent FLORENT, MD, PhD

  Centre Hospitalier Arras

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 15, 2020
• First Posted: May 18, 2020
• Study Start: July 3, 2020
• Primary Completion: November 4, 2021
• Study Completion: November 4, 2021
• Last Updated: March 15, 2022

Record last verified: 2022-03

Locations

FR (1)