Influence of Renal Replacement TherApy on Indirect Calorimetry
IRATIC
1 other identifier
observational
100
1 country
1
Brief Summary
Renal replacement therapy may affect carbon dioxide elimination, which may theoretically influence measurement of energy expenditure by means of indirect calorimetry. However, available clinical studies are noct conclusive on this issue. This observational study aims to investigate the effect of renal replacement therapy on indirect calorimetry in critically ill mechanically ventilated patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 18, 2020
CompletedStudy Start
First participant enrolled
October 20, 2020
CompletedFirst Posted
Study publicly available on registry
October 22, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2024
CompletedDecember 20, 2024
December 1, 2024
3.6 years
October 18, 2020
December 18, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
energy expenditure
energy expenditure in kcal/d
60 minutes
Secondary Outcomes (2)
Carbon dioxide elimination
60 minutes
respiratory quotient
60 minutes
Interventions
indirect calorimetry with and without renal replacement therapy
Eligibility Criteria
critically ill mechanically ventilated medical patients requiring renal replacement therapy
You may qualify if:
- simultaneous requirement for mechanical ventilation and renal replacement therapy
- informed consent
You may not qualify if:
- age \<18 years
- requirement for therapeutic hypothermia
- serum lactate \>4 mmol/l
- requirement for inspiratory oxygen fraction \>0.6 and positive end-expiratory pressure \>12 mbar
- leak in the ventilator circuit (e.g. due to a chest tube)
- requirement for extracorporeal circulatory support
- refusal to participate in the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital of Leipzig
Leipzig, Saxony, D-04103, Germany
Related Publications (1)
Knoll A, Petros S, Pasieka B, Weidhase L. Influence of kidney replacement therapy on indirect calorimetry in critically ill patients. Eur J Clin Nutr. 2025 Nov;79(11):1144-1148. doi: 10.1038/s41430-025-01643-9. Epub 2025 Jul 30.
PMID: 40739037DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sirak Petros, MD
University of Leipzig
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 18, 2020
First Posted
October 22, 2020
Study Start
October 20, 2020
Primary Completion
May 31, 2024
Study Completion
June 30, 2024
Last Updated
December 20, 2024
Record last verified: 2024-12