Attentional Impairment in People With Epilepsy

NCT04379128 | Unknown DMC

• 1 other identifier: 2019-A02748-49
• Study Type: observational
• Target: 272
• Locations: 0 countries
• Sites: N/A

Brief Summary

Epilepsy is one of the most common chronic neurological conditions.It leads to cognitive impairment in 20-50% of patients with a structural form. In comparison with seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. They are particularly frequent (50%) in temporal epilepsies and preferably concern memory and language skills. The cognitive consequences of epilepsy are therefore well described in the following areas: episodic memory, language, executive functions. Concerning attentional abilities, a recent review has highlighted the lack of work in this specific field in order to properly measure the prevalence and nature of attentional disorders in epileptic patients. Indeed, attentional abilities are often mentioned in studies, but attention is a complex domain defined by four modalities: alertness, selective attention, divided attention and sustained attention. No study systematically assesses all of these modalities. The objective of this study is to evaluate the prevalence and nature of attentional disorders in epileptic patients compared to control subjects.

Conditions

Epilepsy

Outcome Measures

Primary Outcomes (1)

• d2-r

  selective attention task

  10 minutes

Secondary Outcomes (3)

• sustained attention TAP Subtest

  15 minutes

• alertness attention TAP Subtest

  8 minutes

• divided attention TAP Subtest

  5 minutes

Other Outcomes (6)

• digit span

  5 minutes

• verbal fluency

  5 minutes

• incompatibility TAP subtest

  8 minutes

Study Arms (2)

patients with epilepsy

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Other: Attentional tasks

Normal controls

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Other: Attentional tasks

Interventions

Attentional tasks OTHER

a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control

Normal controls; patients with epilepsy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

people with epilepsy versus normal control

You may qualify if:

• Patient with epilepsy, according to Fisher et al. (2005).
• Patient with written informed consent
• affiliation to a social security regime is compulsory
• Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.
• Patient 18 years of age and older
• Normal controls:
• Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.
• People 18 years of age and older
• People with no neurological and/or psychiatric history

You may not qualify if:

• for patients: with another progressive neurological condition for all People of full age who are subject to a legal protection measure or who are unable to express their consent People deprived of their liberty by a judicial or administrative decision People who regularly use psychoactive substances (cannabis, alcohol...)

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Related Publications (1)

• Brissart H, Forthoffer N, Maillard L. Attention disorders in adults with epilepsy. Determinants and therapeutic strategies. Rev Neurol (Paris). 2019 Mar;175(3):135-140. doi: 10.1016/j.neurol.2019.01.394. Epub 2019 Feb 28.

  PMID: 30826090 RESULT

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

helene BRISSART, Dr

CONTACT

383851689; h.brissart@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 27, 2020
• First Posted: May 7, 2020
• Study Start: May 1, 2020
• Primary Completion: May 1, 2020
• Study Completion: August 1, 2025
• Last Updated: May 7, 2020

Record last verified: 2020-04

Data Sharing

• IPD Sharing: Will not share