Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy

NCT05455047 | Completed

• 1 other identifier: 2021PI190
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, but underlay broader epileptic networks . Because of the different electroclinical presentations of TLE, 18F-FDG PET appears to be a very useful tool in these temporal epilepsies. Indeed, it has been recently demonstrated that a gradient of PET hypometabolism from the uninvolved area to the spreading area, then to the epileptogenic area and to the lesion area is observed with consequently a good performance of 18F-FDG PET in defining the EZ . Therefore, it is interesting to study PET metabolism as a network and not as a combination of regional metabolic measures in epilepsy.

Conditions

Epilepsy

Outcome Measures

Primary Outcomes (1)

• Metabolic connectivity

  Metabolic connectivity of hypometabolic clusters in each temporal epilepsy subgroup defined by IRCA (interregional correlation analysis) and graph theory

  1 month

Interventions

PET-CT at 18F-FDG DIAGNOSTIC_TEST

PET-CT at 18f6FDG in nuclear medicine departement of Nancy's hospital

Eligibility Criteria

• Age: 18 Years - 56 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients who came to the nuclear medicine department between 2009 and 2021 for an 18F-FDG PET/CT scan as part of a pre-operative assessment for epilepsy surgery

You may qualify if:

• Patients with drug-resistant temporal epilepsy with an accurate diagnosis on SEEG
• Patients with epilepsy who have had a PET/CT scan with 18F-FDG as part of a pre-operative assessment
• Person having received complete information on the organization of the research and not having objected to the use of these data;
• Patients affiliated to a social security system

You may not qualify if:

• Person who has not received full information on the organization of the research and who has opposed the use of this data
• A person of full age who is the subject of a legal protection measure (guardianship, curatorship, safeguard of justice).
• A person of full age who is unable to give consent and who is not subject to a legal protection measure

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Nancy's Hospital

Vandœuvre-lès-Nancy, 54511, France

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: October 13, 2021
• First Posted: July 13, 2022
• Study Start: February 1, 2022
• Primary Completion: March 1, 2022
• Study Completion: June 1, 2022
• Last Updated: August 24, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)