Arithmetic Abilities in Children With 22q11.2DS

NCT04373226 | Terminated

• 1 other identifier: 2020-A00102-37
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.

Conditions

22q11.2 Deletion Syndrome

Keywords

22q11.2 deletion syndrome; arithmetic; magnitude representation; children

Outcome Measures

Primary Outcomes (1)

• Percentage of impaired scaled score

  percentage of impaired scaled score at ZAREKI-R

  single day

Secondary Outcomes (2)

• Percentage of correct responses

  single day

• Mean reaction time

  single day

Study Arms (2)

22q11.2DS

EXPERIMENTAL

Children aged from 4 to 11 years old with 22q11.2 deletion syndrome

Behavioral: Magnitude comparison tasks and neuropsychological testing

NON22q11.2DS

ACTIVE COMPARATOR

Children aged from 4 to 11 years old without developmental disease

Behavioral: Magnitude comparison tasks and neuropsychological testing

Interventions

Magnitude comparison tasks and neuropsychological testing BEHAVIORAL

neuropsychological testing (ZAREKI-R) and magnitude comparison tasks with stimuli of different types (visual, visuo-spatial)

22q11.2DS; NON22q11.2DS

Eligibility Criteria

• Age: 4 Years - 11 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Diagnosis of 22q11.2 deletion syndrome or no developmental disease
• Aged from 4 to 11 years old
• French language

You may not qualify if:

• Diagnosis of intellectual deficiency according to DSM 5 criteria
• Drug prescribed for somatic condition that could influence cerebral functioning

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Hopital Vinatier

Lyon, Auvergne-Rhône-Alpes, 69678, France

Location

Related Publications (1)

• Favre E, Piveteau M, Babinet MN, Demily C. Extent of magnitude representation deficit and relationship with arithmetic skills in children with 22q11.2DS. Orphanet J Rare Dis. 2024 Jul 3;19(1):250. doi: 10.1186/s13023-024-03263-1.

  PMID: 38961462 DERIVED

MeSH Terms

Conditions

DiGeorge Syndrome

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

22q11 Deletion Syndrome; Craniofacial Abnormalities; Musculoskeletal Abnormalities; Musculoskeletal Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Lymphatic Abnormalities; Lymphatic Diseases; Hemic and Lymphatic Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn; Hypoparathyroidism; Parathyroid Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Caroline DEMILY, MD PH

  Centre Hospitalier le Vinatier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Monocentric study with two parallel groups

Study Record Dates

• First Submitted: April 30, 2020
• First Posted: May 4, 2020
• Study Start: September 16, 2020
• Primary Completion: April 14, 2023
• Study Completion: April 14, 2023
• Last Updated: March 7, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)