NCT04367142

Brief Summary

The objective of study is to estimate the sensitivity and specificity of the COR-DIAL based on nasopharyngeal samples taken at the patient's admission in relation to the final diagnosis of COVID-19 made by the medical team.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 27, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 29, 2020

Completed
4 months until next milestone

Study Start

First participant enrolled

August 24, 2020

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 2, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 2, 2023

Completed
Last Updated

December 17, 2024

Status Verified

May 1, 2023

Enrollment Period

2.7 years

First QC Date

April 27, 2020

Last Update Submit

December 12, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Sensitivity and specificity of the COR-DIAL based on nasopharyngeal swabs taken on admission of the patient compared to the final diagnosis of COVID-19 made by the medical team

    Baseline (at admission)

Secondary Outcomes (1)

  • Cohen's Kappa Coefficient for concordance for the diagnosis of CoV-2-SARS between PCR and COR-DIAL based on nasopharyngeal swabs taken on patient admission

    Baseline (at admission)

Study Arms (2)

positive SARS-Cov2

100 patients with a positive diagnosis of SARS-CoV-2

Diagnostic Test: COVID-19 RT-PCRDiagnostic Test: Biosensor

negative SARS-Cov2

100 patients with a negative diagnosis of SARS-CoV-2 defined by the gold standard by the medical team

Diagnostic Test: COVID-19 RT-PCRDiagnostic Test: Biosensor

Interventions

COVID-19 RT-PCRDIAGNOSTIC_TEST

Nasopharyngeal swabs for COVID-19 RT-PCR

negative SARS-Cov2positive SARS-Cov2
BiosensorDIAGNOSTIC_TEST

Portable and Connected Biosensor viral

negative SARS-Cov2positive SARS-Cov2

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients admitted to a Reference Health Establishment for suspicion of SARS-CoV-2

You may qualify if:

  • Male or female or child without age limit
  • Admitted to a Reference Health Establishment in an emergency unit, hospitalisation or intensive care unit for suspicion of SARS-CoV-2 infection, regardless of the clinical presentation and degree of severity.
  • Patient to be diagnosed using a PCR test on nasopharyngeal swab.
  • Social insured

You may not qualify if:

  • Atypical or suspicious cases without a final diagnosis of COVID-19 positive or negative
  • Patient refusal to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU lille

Lille, 59037, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

nasopharyngeal swab and saliva

MeSH Terms

Interventions

COVID-19 Nucleic Acid Testing

Intervention Hierarchy (Ancestors)

COVID-19 TestingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative Techniques

Study Officials

  • Enagnon Kazali ALIDJINOU, MD

    University Hospital, Lille

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 27, 2020

First Posted

April 29, 2020

Study Start

August 24, 2020

Primary Completion

May 2, 2023

Study Completion

May 2, 2023

Last Updated

December 17, 2024

Record last verified: 2023-05

Locations