COVID-19 Seroconversion Among Front Line Medical and Paramedical Staff in Emergency, Intensive Care Units and Infectious Disease Departments During the 2020 Epidemic

NCT04304690 | Completed

• 1 other identifier: APHP200310
• Study Type: interventional
• Target: 1,177
• Locations: 1 country
• Sites: 1

Brief Summary

The epidemic due to the Sars-CoV2 virus is spreading in France, without knowning precisely since when the virus has actually circulated on the territory. Data from China but also systematic samples taken from the passengers of the Diamond Princess boat also report almost 50% of asymptomatic forms of Covid-19. The medical and paramedical staff of the front-line services for the care of patients infected with Covid-19 are in fact potentially exposed to the risk of occupational contamination due to the large number of patients treated, including in the pre-epidemic phase. Therefore, and despite the application of standard protective measures, it is possible that a certain number of these personnel already have or will contract Covid-19 disease, including in its asymptomatic form.

Conditions

Sars-CoV2

Outcome Measures

Primary Outcomes (1)

• Quantify the proportion of patients with documented Sars-CoV2 infection among medical and paramedical staff

  Sars-CoV2 seroconversion is defined by a T0 sample with no specific antibody (negative) and M3 sample with the presence of specific IgG.

  3 months

Secondary Outcomes (3)

• Identification of risk factors for seroconversion

  3 months

• Quantify the proportion of asymptomatic infections among staff who have seroconverted

  3 months

• " Describe symptomatic infections for personnel developing acute clinical (respiratory or digestive) viral syndrome "

  3 months

Study Arms (1)

caregiver

OTHER

caregivers from emergency, ICU, virology and infectious disease services

Other: blood sample

Interventions

blood sample OTHER

2 blood samples at T0 and 3 months

caregiver

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Any permanent medical or paramedic staff of participating services who have given written consent to participate
• Having a social security insurance.

You may not qualify if:

• Non-permanent staff (occasional staffing), administrative staff, technical staff of participating services.

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Hopital Pitié Salpetrière

Paris, 75013, France

Location

Related Publications (1)

• Hausfater P, Boutolleau D, Lacombe K, Beurton A, Dumont M, Constantin JM, Ghosn J, Combes A, Cury N, Guedj R, Djibre M, Bompard R, Mazerand S, Pourcher V, Gimeno L, Marois C, Teyssou E, Marcelin AG, Hajage D, Tubach F. Cumulative incidence of SARS-CoV-2 infection and associated risk factors among frontline health care workers in Paris: the SEROCOV cohort study. Sci Rep. 2022 May 4;12(1):7211. doi: 10.1038/s41598-022-10945-y.

  PMID: 35508515 DERIVED

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2020
• First Posted: March 11, 2020
• Study Start: March 16, 2020
• Primary Completion: July 7, 2021
• Study Completion: July 7, 2021
• Last Updated: July 6, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)