Brief Summary

Walking deficits and altered brain capacity have been proved to be two of the main contributing factors in dual-task walking deficits in patients with Parkinson's disease (PD). In the past, patients with PD were usually suggested not to walk in dual-task conditions in order to concentrate on their walking performance better. However, since dual-task walking is really common in daily-life, this limitation usually lead to a decrease in quality of life for PD patients. In previous studies, effects of using attentional strategies in dual-task walking training remain unclear, while suitable attentional strategies and corresponded neuroplasticity for patients with and without freezing of gait have not been well discussed, either. Accordingly, this study is aimed to identify (1) whether internal or external attentional strategies is more ideal for PD patients with and without freezing of gait in dual-task walking training, and (2) changes in brain activity after receiving dual-task walking training with different attentional strategies in patients with or without freezing of gait. Our hypothesis are (1) patients with or without freezing of gait will react differently in dual-gait training with different attentional strategies, and (2) changes in brain activities will be different according to different attentional strategies given in the training.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at P50-P75 for not_applicable parkinson-disease

Timeline

Completed

Started Aug 2020

Typical duration for not_applicable parkinson-disease

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

3 years study duration

First Submitted

Initial submission to the registry

April 23, 2020

Completed

4 days until next milestone

First Posted

Study publicly available on registry

April 27, 2020

Completed

3 months until next milestone

Study Start

First participant enrolled

August 6, 2020

Completed

12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2021

Completed

2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2023

Completed

Last Updated

September 7, 2023

Status Verified

August 1, 2023

Enrollment Period

12 months

First QC Date

April 23, 2020

Last Update Submit

September 5, 2023

Conditions

Parkinson Disease Dual-task Walking

Keywords

Parkinsondual-task trainingattentionelectroencephalogram (EEG)

Outcome Measures

Primary Outcomes (8)

Gait velocity from GAITRite
gait performance
60 minutes
Cadence from GAITRite
gait performance
60 minutes
Mean step length from GAITRite
gait performance
60 minutes
Step-to-step variability from GAITRite
gait performance
60 minutes
Amplitude from a triaxial accelerometer, X axes
motor suprapostural task performance
25 minutes
Amplitude from a triaxial accelerometer, Y axes
motor suprapostural task performance
25 minutes
Amplitude from a triaxial accelerometer, Z axes
motor suprapostural task performance
25 minutes
Correct rate on working memory task
cognitive suprapostural task performance
25 minutes

Secondary Outcomes (5)

EEG relative power in the delta band
60 minutes
EEG relative power in the theta band
60 minutes
EEG relative power in the alpha band
60 minutes
EEG relative power in the beta band
60 minutes
EEG relative power in the low gamma band
60 minutes

Study Arms (6)

PD patients with freezing of gait, internal strategies

EXPERIMENTAL

Participants in this group will include PD patients with freezing of gait. During dual-task walking training, internal attentional strategies will be given, aiming to improve their gait performance.