Link Between Eosinopenia and Bacterial Infections in the Elderly Subject Hospitalized in Geriatrics

NCT04363138 | Completed DMC

• 1 other identifier: 2020-A00301-38
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this monocentric, non-interventional, prospective study carried out in acute geriatrics (UGA) and post-rehabilitation care, is to determine if eosinopenia is associated with bacterial infections.

Conditions

Fever; Leukocytes; C Reactive Protein (CRP) is Less Than 20 mg/ l

Keywords

Eosinopenia; Bacterial infections

Outcome Measures

Primary Outcomes (1)

• Determine if eosinopenia is associated with bacterial infections by measuring eosinophil counts.

  1 month

Secondary Outcomes (4)

• Determine if eosinopenia is associated with the effectiveness of antibiotics by measuring eosinophil counts.

  1 month

• Determine if the eosinophil counts (PNE) / neutrophil (PNN)x1000 < 4 ratio is associated with a bacterial infection by measuring this value.

  1 month

• Determine if eosinopenia is associated with mortality by measuring eosinophil counts.

  1 month

• Determine if deep eosinopenia is associated with bacterial involvement by measuring if this value is less than 10 per mm3.

  1 month.

Study Arms (2)

bacterial infection

Patients with bacterial infection

No bacterial infection

Patients without bacterial infection

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects above 75 years of age, hospitalized in geriatrics.

You may qualify if:

• Hospitalized in Geriatrics.
• First episode of:
• Fever\> 38 ° motivating the realization of a biological assessment.
• Or Leukocytes\> 10 g / l and C reactive protein (CRP) \> 20 mg / l.
• Be affiliated to a social security scheme.
• No oral opposition to participation in the study and use of the data.

You may not qualify if:

• Immunosuppression (HIV with CD4 \<200 / mm3)
• Active corticosteroid therapy
• Asthma
• Chemotherapy, immunosuppressive treatment
• Malignant hematological disease, lympho or myeloproliferative syndrome
• Antibiotic therapy initiated before entering the geriatric ward
• Documented parasitosis
• Eosinophilic vasculitis
• stroke \<30 days
• Patient already included in another study
• Patient under guardianship or curatorship
• Not affiliated with a social security scheme
• Oral opposition to participation in the study

Sponsors & Collaborators

• Gérond'if: lead

Study Sites (1)

Geriatric Department, Paul Brousse Hospital

Villejuif, Île-de-France Region, 94800, France

Location

Related Publications (1)

• Mesinele L, Pujol T, Brunetti N, Neiss M, Trivalle C, Souques C, Houenou-Quenum N, Verdier S, Simon P, Vetillard AL, Houdre J, Collarino R, Mary M, Vidal JS, Kahn JE, Guichardon M, Duron E, Baudouin E. Association between low eosinophil count and acute bacterial infection, a prospective study in hospitalized older adults. BMC Geriatr. 2023 Dec 13;23(1):852. doi: 10.1186/s12877-023-04581-y.

  PMID: 38093181 DERIVED

MeSH Terms

Conditions

Fever; Bacterial Infections

Condition Hierarchy (Ancestors)

Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Bacterial Infections and Mycoses; Infections

Study Officials

• Emmanuelle DURON, MD PhD

  Geriatric Department, Paul Brousse Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 23, 2020
• First Posted: April 27, 2020
• Study Start: July 2, 2021
• Primary Completion: August 1, 2021
• Study Completion: August 1, 2022
• Last Updated: January 12, 2023

Record last verified: 2023-01

Locations

FR (1)