Treatment Of Fever In The Emergency Department
Treatment Of Fever And Associated Symptoms In The Emergency Department: Which Drug To Choose?
1 other identifier
observational
324
1 country
1
Brief Summary
Fever is a frequent cause of admission to the Emergency Department (ED) around the world. While it can be caused by a wide range of conditions, the most effective treatment based on its etiology is still undetermined. This observational, prospective, single-center study enrolled adult patients who accessed the ED for fever, with the aim to define the most effective treatment for them.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2022
CompletedFirst Submitted
Initial submission to the registry
February 14, 2023
CompletedFirst Posted
Study publicly available on registry
April 14, 2023
CompletedApril 14, 2023
February 1, 2023
1 year
February 14, 2023
April 13, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
body temperature
the reduction of 1-degree of body temperature after 1 hour (T1) after the drug administration
1 hour
Numerical Rating Scale (NRS)
the reduction of 1-point for all associated symptoms on NRS after 1 hour (T1) after the drug administration. NRS is a "0-10" scale tool to assess pain severity, with zero that means "no pain" and 10 "the worst pain".
1 hour
Secondary Outcomes (3)
the reduction of at least 2 points on the Numerical Rating Scale (NRS) after two hours (T2) after the drug administration
2 hours
rescue therapy
2 hours
adverse events
2 hours
Interventions
Emergency physicians were free to administer paracetamol 1000 mg (P), the combination paracetamol 500 mg/ibuprofen 150 mg (PI) or Ibuprofen 600 mg (I)
Eligibility Criteria
Adults \> 18 years old with fever and associated symptoms accessing the ED
You may qualify if:
- fever with/without associated symptoms
- adults who had given their consent to participate in the study.
You may not qualify if:
- age \< 18 years old
- contraindications or allergies to Paracetamol, Ibuprofen or to the combination Paracetamol/Ibuprofen
- patients unable to take oral drugs
- patients who did not express their consent to participate to the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS
Roma, 00168, Italy
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 14, 2023
First Posted
April 14, 2023
Study Start
June 1, 2021
Primary Completion
June 1, 2022
Study Completion
July 1, 2022
Last Updated
April 14, 2023
Record last verified: 2023-02