NCT04350255

Brief Summary

In a prospective register-based study, we aim to evaluate the implant survival, clinical outcomes and X-ray findings by following a cohort of patients operated with the Trident II cup.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for not_applicable

Timeline
52mo left

Started Aug 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress58%
Aug 2020Aug 2030

First Submitted

Initial submission to the registry

April 8, 2020

Completed
9 days until next milestone

First Posted

Study publicly available on registry

April 17, 2020

Completed
4 months until next milestone

Study Start

First participant enrolled

August 1, 2020

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2024

Completed
5.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2030

Expected
Last Updated

October 4, 2022

Status Verified

October 1, 2022

Enrollment Period

4.3 years

First QC Date

April 8, 2020

Last Update Submit

October 3, 2022

Conditions

Keywords

Hip arthroplastyImplant survivalClinical outcomeX-rayImplant MigrationPatient reported outcomes

Outcome Measures

Primary Outcomes (1)

  • Implant survival at 3 years

    Kaplan Meier survival data, cup revision and risk of revision used as endpoints

    3 years

Secondary Outcomes (8)

  • Implant migration measured with Computer Tomography Microanalysis in a subcohort of patients motion Analysis (CTMA) in a sub-cohort of patients

    CTMA will be done postoperatively, 3 month and 6 months and 2 years after total hip replacement

  • Implant survival at 10 years

    10 years

  • EQ-5D

    10 years

  • Plain radiographs in a sub-cohort of patients

    10 years

  • Adverse events using the national patient register

    10 years

  • +3 more secondary outcomes

Study Arms (2)

Trident II Hemispherical cup (Stryker Orthopaedics)

ACTIVE COMPARATOR

Total hip arthroplasty using non cemented Trident II Hemispherical acetabular cup

Device: Total hip arthroplasty

Trident II Tritanium cup (Stryker Orthopaedics)

ACTIVE COMPARATOR

Total hip arthroplasty using non cemented Trident II Tritanium acetabular cup

Device: Total hip arthroplasty

Interventions

Total hip arthroplasty with a Trident II hemispherical cup

Trident II Hemispherical cup (Stryker Orthopaedics)Trident II Tritanium cup (Stryker Orthopaedics)

Eligibility Criteria

Age30 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Primary hip replacement
  • Eligible for uncemented fixation of the acetabular component
  • Suitable for one of the stem designs from Stryker Orthopaedics
  • Accepts follow-up according to the study protocol

You may not qualify if:

  • Difficulties to understand written information due to language problems or other reasons
  • Use of augments needed
  • Acute hip fracture
  • Tumor in the hip joint

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Orthopaedics

Mölndal, Västra Götaland County, S-43180, Sweden

RECRUITING

MeSH Terms

Interventions

Arthroplasty, Replacement, Hip

Intervention Hierarchy (Ancestors)

Arthroplasty, ReplacementArthroplastyOrthopedic ProceduresSurgical Procedures, OperativePlastic Surgery ProceduresProsthesis Implantation

Central Study Contacts

Maziar Mohaddes, MD, PhD

CONTACT

Adam Rosenbaum, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Sahlgrenska University Hospital, Sweden

Study Record Dates

First Submitted

April 8, 2020

First Posted

April 17, 2020

Study Start

August 1, 2020

Primary Completion

December 1, 2024

Study Completion (Estimated)

August 1, 2030

Last Updated

October 4, 2022

Record last verified: 2022-10

Data Sharing

IPD Sharing
Will not share

Due to regulations associated with national registers in Sweden alla data will be presented on an aggregated level, individual patient data will not be shared.

Locations