Quantitative Analysis of Global Proteome in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture

NCT03428672 | Unknown

• 1 other identifier: Xu youjia 003
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to quantitatively analyze the differentially expressed proteins to further explain the relationship between bone iron content and bone mineral density (BMD). PURPOSE: This research study is looking at changes of iron content and differentially expressed proteins in bone samples from patients with osteoporotic and nonosteoporotic. fracture.

Conditions

Femoral Neck Fractures

Outcome Measures

Primary Outcomes (1)

• the iron content in human bone samples

  Bone samples were preprocess and decomposed by microwave.Icp-ms is used for quantitative detection of samples.

  3 month

Secondary Outcomes (2)

• The value of bone mineral density

  one week

• Quantitative Analysis of Global Proteome in bone samples

  5 month

Study Arms (2)

osteoporotic fractures

EXPERIMENTAL

patients with osteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.

Procedure: total hip arthroplasty

nonosteoporotic fractures

SHAM COMPARATOR

patients with nonosteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.

Procedure: total hip arthroplasty

Interventions

total hip arthroplasty PROCEDURE

Bone samples from Hip fracture were collected from the femoral head which has been replaced

nonosteoporotic fractures; osteoporotic fractures

Eligibility Criteria

• Age: 55 Years - 90 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ages Eligible for Study: 55-90 Years
• Genders Eligible for Study: Woman
• Accepts Healthy Volunteers: NO
• Study Population: Female patients with hip fracture.

You may not qualify if:

• Malignancy or benign ovarian cysts
• Known chronic or systemic diseases
• Hormone therapy in the previous 3 months
• Bone metabolism and drug therapy

Sponsors & Collaborators

• Second Affiliated Hospital of Soochow University: lead

Study Sites (1)

Second Affiliated Hospital of Soochow University

Suzhou, Jiagnsu, 215004, China

Location

Related Publications (5)

• Geyer PE, Wewer Albrechtsen NJ, Tyanova S, Grassl N, Iepsen EW, Lundgren J, Madsbad S, Holst JJ, Torekov SS, Mann M. Proteomics reveals the effects of sustained weight loss on the human plasma proteome. Mol Syst Biol. 2016 Dec 22;12(12):901. doi: 10.15252/msb.20167357.

  PMID: 28007936 RESULT

• Roumeliotis TI, Williams SP, Goncalves E, Alsinet C, Del Castillo Velasco-Herrera M, Aben N, Ghavidel FZ, Michaut M, Schubert M, Price S, Wright JC, Yu L, Yang M, Dienstmann R, Guinney J, Beltrao P, Brazma A, Pardo M, Stegle O, Adams DJ, Wessels L, Saez-Rodriguez J, McDermott U, Choudhary JS. Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells. Cell Rep. 2017 Aug 29;20(9):2201-2214. doi: 10.1016/j.celrep.2017.08.010.

  PMID: 28854368 RESULT

• Zeng Y, Zhang L, Zhu W, Xu C, He H, Zhou Y, Liu YZ, Tian Q, Zhang JG, Deng FY, Hu HG, Zhang LS, Deng HW. Corrigendum to "Quantitative proteomics and integrative network analysis identified novel genes and pathways related to osteoporosis" [J. Proteomics 142 (16 June 2016) 45-52]. J Proteomics. 2017 Jun 6;162:155. doi: 10.1016/j.jprot.2017.05.023. No abstract available.

  PMID: 28578906 RESULT

• Kuo HW, Kuo SM, Chou CH, Lee TC. Determination of 14 elements in Taiwanese bones. Sci Total Environ. 2000 Jun 8;255(1-3):45-54. doi: 10.1016/s0048-9697(00)00448-4.

  PMID: 10898394 RESULT

• Brodziak-Dopierala B, Kwapulinski J, Sobczyk K, Wiechula D. The content of manganese and iron in hip joint tissue. J Trace Elem Med Biol. 2013 Jul;27(3):208-12. doi: 10.1016/j.jtemb.2012.12.005. Epub 2013 Feb 15.

  PMID: 23415599 RESULT

MeSH Terms

Conditions

Femoral Neck Fractures

Interventions

Arthroplasty, Replacement, Hip

Condition Hierarchy (Ancestors)

Hip Fractures; Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Intervention Hierarchy (Ancestors)

Arthroplasty, Replacement; Arthroplasty; Orthopedic Procedures; Surgical Procedures, Operative; Plastic Surgery Procedures; Prosthesis Implantation

Study Officials

• Youjia Xu, PhD

  Second Affiliated Hospital of Soochow University

  STUDY CHAIR

Central Study Contacts

Youjia Xu, PhD

CONTACT

86-0512-67783346; xuyoujia@suda.edu.cn

Fan Yang, MSc

CONTACT

86-0512-67784115; 1066276684@qq.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: January 31, 2018
• First Posted: February 12, 2018
• Study Start: April 1, 2018
• Primary Completion: January 1, 2019
• Study Completion: May 1, 2019
• Last Updated: February 12, 2018

Record last verified: 2018-02

Locations

CN (1)