NCT04344132

Brief Summary

Study was designed to evaluate optimal timing for selective scalp block in patients undergoing general anesthesia for supratentorial craniotomy.Pain score assessed by visual analog scale (VAS) preoperatively (baseline) and after extubation at 2, 6, 12 and 24 hours; time first request of a patient for rescue analgesia; intraoperative anesthetics and opioids consumption; awakening time; perioperative complications.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2020

Shorter than P25 for not_applicable

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 30, 2020

Completed
15 days until next milestone

First Posted

Study publicly available on registry

April 14, 2020

Completed
6 days until next milestone

Study Start

First participant enrolled

April 20, 2020

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2020

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2020

Completed
Last Updated

April 15, 2020

Status Verified

April 1, 2020

Enrollment Period

7 months

First QC Date

March 30, 2020

Last Update Submit

April 14, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Visual Analogue Scale score at 24 h after surgery

    Visual Analogue Scale ranging from 0 (no pain) to 10 (worst imaginable pain),

    up to 24 hours

Secondary Outcomes (9)

  • Visual Analogue Scale score at 0

    Baseline

  • Visual Analogue Scale score at 2 hours

    up to 2 hours

  • Visual Analogue Scale score at 6 hours

    up to 6 hours

  • Visual Analogue Scale score at 12 hours

    up to 12 hours

  • time first request of a patient for rescue analgesia

    during surgery

  • +4 more secondary outcomes

Interventions

Scalp BlockPROCEDURE

standard practice of controll the pain after surgery. Block of the nerve emergences.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patients (\>18 years),
  • presenting with supratentorial brain tumors scheduled for elective craniotomy under general anesthesia

You may not qualify if:

  • history of allergic reactions on local anesthetics;
  • ASA status ≥ 3;
  • depressed consciousness in pre- or postoperative period;
  • aphasia (as investigators were not able to obtain VAS score).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Bebawy JF, Bilotta F, Koht A. A modified technique for auriculotemporal nerve blockade when performing selective scalp nerve block for craniotomy. J Neurosurg Anesthesiol. 2014 Jul;26(3):271-2. doi: 10.1097/ANA.0000000000000032. No abstract available.

    PMID: 24492515BACKGROUND
  • Tsaousi GG, Logan SW, Bilotta F. Postoperative Pain Control Following Craniotomy: A Systematic Review of Recent Clinical Literature. Pain Pract. 2017 Sep;17(7):968-981. doi: 10.1111/papr.12548. Epub 2017 Feb 23.

    PMID: 27996204BACKGROUND

MeSH Terms

Conditions

Supratentorial Neoplasms

Condition Hierarchy (Ancestors)

Brain NeoplasmsCentral Nervous System NeoplasmsNervous System NeoplasmsNeoplasms by SiteNeoplasmsBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

March 30, 2020

First Posted

April 14, 2020

Study Start

April 20, 2020

Primary Completion

November 30, 2020

Study Completion

December 30, 2020

Last Updated

April 15, 2020

Record last verified: 2020-04