Study Stopped
The study has been terminated due to the pandemic.
Stevia Extract and Glucose Homeostasis
Effect of Stevia Extract on Postprandial Glucose Response and Satiety in Overweight and Obese Adults: A Three-arm Crossover Trial.
1 other identifier
interventional
N/A
1 country
1
Brief Summary
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Mar 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 3, 2020
CompletedFirst Submitted
Initial submission to the registry
April 2, 2020
CompletedFirst Posted
Study publicly available on registry
April 6, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 15, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
February 15, 2021
CompletedMay 10, 2021
April 1, 2020
12 months
April 2, 2020
May 7, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Postprandial glucose levels
Change in glucose levels two hours after the administration of a fixed meal
Capillary blood glucose will be measured two hours after the administration of a fixed meal.
Secondary Outcomes (3)
Postprandial insulin levels
Postprandial insulin levels will be measured two hours of the administration of a fixed meal
Area under the curve (AUC) for glucose
Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch
Subjective feelings of satiety
VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.
Study Arms (3)
Water
NO INTERVENTION250 ml of water mixed with 1g of citric acid.
Sugar
ACTIVE COMPARATOR65g of sugar dissolved in 250ml of water
Stevia
EXPERIMENTAL5g of stevia dissolved in 250ml of water
Interventions
Participants will receive a solution of stevia before being administered a fixed meal (lunch). Glucose and insulin levels, and Visual analogue scale data will be collected.
Eligibility Criteria
You may qualify if:
- Age 18-65 years
- BMI 27-40 Kg/m2
- Males and females
You may not qualify if:
- Athletes
- Pregnant or breastfeeding women
- Patients with chronic disease (diabetes, CVD etc…).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
School of Health sciences, Liverpool Hope University
Liverpool, L16 9JD, United Kingdom
Related Publications (1)
Farhat G, Berset V, Moore L. Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial. Nutrients. 2019 Dec 12;11(12):3036. doi: 10.3390/nu11123036.
PMID: 31842388BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Farzad Amirabdollahian, PhD
Liverpool Hope University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- Single (participant)
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
April 2, 2020
First Posted
April 6, 2020
Study Start
March 3, 2020
Primary Completion
February 15, 2021
Study Completion
February 15, 2021
Last Updated
May 10, 2021
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share