Psychiatry of Transition in a World in Transition

NCT04333797 | Completed

• 1 other identifier: P2020/PSY/Transition_psy
• Study Type: interventional
• Target: 252
• Locations: 1 country
• Sites: 4

Brief Summary

This clinical study evaluates risk and protective factor to develop psychopathology in transitional age youth. 300 patients will be recruited at the age of 17 years old and assessed at baseline and 2 years later.

Conditions

Transitional Care; Mental Disorder in Adolescence; Mental Health

Keywords

Transitional age youth; CAMHS; AMHS; Dimensional approach; Child and Adolescent Psychiatry services; Adult Psychiatry services

Outcome Measures

Primary Outcomes (2)

• Change from Baseline self-rated mental health status (need for care) at 2 years

  Measured at baseline (T0) and follow-up (T1) with the Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA).

  Change from Baseline HoNOSCA before transition at 17 y.o. to after transition at 19 y.o.

• Change from Baseline self-rated measure of quality of life at 2 years

  Measured at baseline (T0) and follow-up (T1) with the Quality of life assessed by World Health Organisation Quality of Life Assessment (WHO-QoL-BREF)

  Change from Baseline WHO-QoL before transition at 17 y.o. to after transition at 19 y.o

Secondary Outcomes (18)

• Self-rated measure of traumatic life events

  Before transition at 17 y.o. (T0)

• Self-rated measure of family functioning

  Before transition at 17 y.o. (T0)

• Self-rated measure to quantify the risk of developing psychiatric disorders

  Before transition at 17 y.o. (T0)

• Self-rated measure of internalising and externalising symptoms

  Before transition at 17 y.o. (T0)

• Self-rated measure of impulsivity and compulsivity

  Before transition at 17 y.o. (T0)

Study Arms (1)

Transitional age youth

OTHER

Assessed group.

Other: Risk and Protective Factors Assessment

Interventions

Risk and Protective Factors Assessment OTHER

First assessment at baseline (T0) - 17 y.o. Follow-up 2 years later (T1) - 19 y.o.

Also known as: Transitional care from CAMHS to AMHS

Transitional age youth

Eligibility Criteria

• Age: 17 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• French-speaking and French-understanding
• Subjects who accepted to participated to the study (signature of informed consent/assent document from subjects and parents or legal holder of parental authority)
• Specific criteria for patients: inpatients and out-patients
• Specific criteria for control group: youth from general population or placed in residential centres

You may not qualify if:

• Impossibility to answer to the assessment tools
• Medium intellectual disability (homogenous IQ \< 75)
• Presence of a grave somatic disease (cancer, cardiac failure, renal failure, central nervous system disorder), that is progressive or that affects the vital prognosis in the short term
• Active participation to another study

Sponsors & Collaborators

• Brugmann University Hospital: collaborator
• Service santé mentale à l'ULB: collaborator
• Université Libre de Bruxelles: collaborator
• King Baudouin Foundation: collaborator
• Erasme University Hospital: collaborator
• Queen Fabiola Children's University Hospital: lead

Study Sites (4)

Brugmann University Hospital

Brussels, 1020, Belgium

Location

Hôpital Universitaire Des Enfants Reine Fabiola

Brussels, 1020, Belgium

Location

Service santé mentale à l'ULB

Brussels, 1050, Belgium

Location

Erasme University Hospital

Brussels, 1070, Belgium

Location

Related Publications (56)

• Caspi A, Moffitt TE. All for One and One for All: Mental Disorders in One Dimension. Am J Psychiatry. 2018 Sep 1;175(9):831-844. doi: 10.1176/appi.ajp.2018.17121383. Epub 2018 Apr 6.

  PMID: 29621902 BACKGROUND

• Tuomainen H, Schulze U, Warwick J, Paul M, Dieleman GC, Franic T, Madan J, Maras A, McNicholas F, Purper-Ouakil D, Santosh P, Signorini G, Street C, Tremmery S, Verhulst FC, Wolke D, Singh SP; MILESTONE consortium. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology. BMC Psychiatry. 2018 Jun 4;18(1):167. doi: 10.1186/s12888-018-1758-z.

  PMID: 29866202 BACKGROUND

• Singh SP, Paul M, Ford T, Kramer T, Weaver T. Transitions of care from Child and Adolescent Mental Health Services to Adult Mental Health Services (TRACK Study): a study of protocols in Greater London. BMC Health Serv Res. 2008 Jun 23;8:135. doi: 10.1186/1472-6963-8-135.

  PMID: 18573214 BACKGROUND

• Hovish K, Weaver T, Islam Z, Paul M, Singh SP. Transition experiences of mental health service users, parents, and professionals in the United Kingdom: a qualitative study. Psychiatr Rehabil J. 2012 Winter;35(3):251-7. doi: 10.2975/35.3.2012.251.257.

  PMID: 22246124 BACKGROUND

• Leebens PK, Williamson ED. Developmental Psychopathology: Risk and Resilience in the Transition to Young Adulthood. Child Adolesc Psychiatr Clin N Am. 2017 Apr;26(2):143-156. doi: 10.1016/j.chc.2016.12.001.

  PMID: 28314447 BACKGROUND

• Singh SP, Tuomainen H. Transition from child to adult mental health services: needs, barriers, experiences and new models of care. World Psychiatry. 2015 Oct;14(3):358-61. doi: 10.1002/wps.20266. No abstract available.

  PMID: 26407794 BACKGROUND

• Paul M, Street C, Wheeler N, Singh SP. Transition to adult services for young people with mental health needs: A systematic review. Clin Child Psychol Psychiatry. 2015 Jul;20(3):436-57. doi: 10.1177/1359104514526603. Epub 2014 Apr 7.

  PMID: 24711585 BACKGROUND

• McGorry P, Bates T, Birchwood M. Designing youth mental health services for the 21st century: examples from Australia, Ireland and the UK. Br J Psychiatry Suppl. 2013 Jan;54:s30-5. doi: 10.1192/bjp.bp.112.119214.

  PMID: 23288499 BACKGROUND

• Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, Sawyer SM, Mathers CD. Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet. 2011 Jun 18;377(9783):2093-102. doi: 10.1016/S0140-6736(11)60512-6. Epub 2011 Jun 7.

  PMID: 21652063 BACKGROUND

• Kotov R, Ruggero CJ, Krueger RF, Watson D, Yuan Q, Zimmerman M. New dimensions in the quantitative classification of mental illness. Arch Gen Psychiatry. 2011 Oct;68(10):1003-11. doi: 10.1001/archgenpsychiatry.2011.107.

  PMID: 21969458 BACKGROUND

• Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Arch Gen Psychiatry. 2003 Jul;60(7):709-17. doi: 10.1001/archpsyc.60.7.709.

  PMID: 12860775 BACKGROUND

• Jones PB. Adult mental health disorders and their age at onset. Br J Psychiatry Suppl. 2013 Jan;54:s5-10. doi: 10.1192/bjp.bp.112.119164.

  PMID: 23288502 BACKGROUND

• Snyder HR, Gulley LD, Bijttebier P, Hartman CA, Oldehinkel AJ, Mezulis A, Young JF, Hankin BL. Adolescent emotionality and effortful control: Core latent constructs and links to psychopathology and functioning. J Pers Soc Psychol. 2015 Dec;109(6):1132-49. doi: 10.1037/pspp0000047. Epub 2015 May 25.

  PMID: 26011660 BACKGROUND

• Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun;62(6):593-602. doi: 10.1001/archpsyc.62.6.593.

  PMID: 15939837 BACKGROUND

• Copeland WE, Wolke D, Shanahan L, Costello EJ. Adult Functional Outcomes of Common Childhood Psychiatric Problems: A Prospective, Longitudinal Study. JAMA Psychiatry. 2015 Sep;72(9):892-9. doi: 10.1001/jamapsychiatry.2015.0730.

  PMID: 26176785 BACKGROUND

• Ormel J, Oerlemans AM, Raven D, Laceulle OM, Hartman CA, Veenstra R, Verhulst FC, Vollebergh W, Rosmalen JG, Reijneveld SA, Oldehinkel AJ. Functional outcomes of child and adolescent mental disorders. Current disorder most important but psychiatric history matters as well. Psychol Med. 2017 May;47(7):1271-1282. doi: 10.1017/S0033291716003445. Epub 2017 Jan 9.

  PMID: 28065168 BACKGROUND

• Kessler RC, Amminger GP, Aguilar-Gaxiola S, Alonso J, Lee S, Ustun TB. Age of onset of mental disorders: a review of recent literature. Curr Opin Psychiatry. 2007 Jul;20(4):359-64. doi: 10.1097/YCO.0b013e32816ebc8c.

  PMID: 17551351 BACKGROUND

• Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci. 2008 Dec;9(12):947-57. doi: 10.1038/nrn2513. Epub 2008 Nov 12.

  PMID: 19002191 BACKGROUND

• Chatburn A, Coussens S, Kohler MJ. Resiliency as a mediator of the impact of sleep on child and adolescent behavior. Nat Sci Sleep. 2013 Dec 23;6:1-9. doi: 10.2147/NSS.S54913. eCollection 2013.

  PMID: 24379734 BACKGROUND

• Andersen SL. Commentary on the special issue on the adolescent brain: Adolescence, trajectories, and the importance of prevention. Neurosci Biobehav Rev. 2016 Nov;70:329-333. doi: 10.1016/j.neubiorev.2016.07.012. Epub 2016 Jul 14.

  PMID: 27423540 BACKGROUND

• Georgieff N. L'adolescence à l'épreuve de la neurobiologie ? Adolescence [Internet]. 2013;T.31 1(1):185. Available from: http://www.cairn.info/revue-adolescence-2013-1-page-185.htm

  BACKGROUND

• National Institute of Mental Health. The Teen Brain: Still Under Construction. Natl Inst Ment Heal [Internet]. 2011;1-10. Available from: http://www.nimh.nih.gov/health/publications/the-teen-brain-still-under-construction/index.shtml

  BACKGROUND

• Copeland W, Shanahan L, Costello EJ, Angold A. Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study. J Am Acad Child Adolesc Psychiatry. 2011 Mar;50(3):252-61. doi: 10.1016/j.jaac.2010.12.014. Epub 2011 Jan 26.

  PMID: 21334565 BACKGROUND

• Lamb, C., Hall, D., Kelvin, R., & Van Beinum M. Working at the CAMHS/Adult Interface: Good practice guidance for the provision of psychiatric services to adolescents/young adults. London R Coll Psychiatr. 2008;

  BACKGROUND

• Jivanjee, P., & Kruzich J. Supports for young people with mental health conditions and their families in the transition years. Best Pract Ment Health. 2011;7(1):115-33.

  BACKGROUND

• Pottick KJ, Bilder S, Vander Stoep A, Warner LA, Alvarez MF. US patterns of mental health service utilization for transition-age youth and young adults. J Behav Health Serv Res. 2008 Oct;35(4):373-89. doi: 10.1007/s11414-007-9080-4. Epub 2007 Nov 17.

  PMID: 18026842 BACKGROUND

• Blum RW, Garell D, Hodgman CH, Jorissen TW, Okinow NA, Orr DP, Slap GB. Transition from child-centered to adult health-care systems for adolescents with chronic conditions. A position paper of the Society for Adolescent Medicine. J Adolesc Health. 1993 Nov;14(7):570-6. doi: 10.1016/1054-139x(93)90143-d. No abstract available.

  PMID: 8312295 BACKGROUND

• Singh SP, Paul M, Ford T, Kramer T, Weaver T, McLaren S, Hovish K, Islam Z, Belling R, White S. Process, outcome and experience of transition from child to adult mental healthcare: multiperspective study. Br J Psychiatry. 2010 Oct;197(4):305-12. doi: 10.1192/bjp.bp.109.075135.

  PMID: 20884954 BACKGROUND

• Cosgrave EM, Yung AR, Killackey EJ, Buckby JA, Godfrey KA, Stanford CA, et al. Met and unmet need in youth mental health. J Ment Heal [Internet]. 2008 Jan 6;17(6):618-28. Available from: http://www.tandfonline.com/doi/full/10.1080/09638230701506267

  BACKGROUND

• Singh SP. Transition of care from child to adult mental health services: the great divide. Curr Opin Psychiatry. 2009 Jul;22(4):386-90. doi: 10.1097/YCO.0b013e32832c9221.

  PMID: 19417667 BACKGROUND

• Achenbach T. Youth Self-Report Form and Profile for Ages 11-18 (YSR/11-18). Itaca, Ill Riverside. 1991;

  BACKGROUND

• Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995 Nov;51(6):768-74. doi: 10.1002/1097-4679(199511)51:63.0.co;2-1.

  PMID: 8778124 BACKGROUND

• Beck A, Steer R, Brown G. Beck depression inventory-II. San Antonio. 1996;78(2):490.

  BACKGROUND

• Beck A, Steer R. BSS: Beck scale for suicide ideation. Psychol Corp. 1991;

  BACKGROUND

• Gosling CJ, Noblecourt K, Moutier S. Questionnaire de régulation émotionnelle pour enfants et adolescents. Enfance. 2018;N°2(2):291.

  BACKGROUND

• Goldberg D, Williams P. General health questionnaire (GHQ). Swindon, Wiltshire, UK nferNelson. 2000

  BACKGROUND

• Gowers SG, Harrington RC, Whitton A, Lelliott P, Beevor A, Wing J, Jezzard R. Brief scale for measuring the outcomes of emotional and behavioural disorders in children. Health of the Nation Outcome Scales for children and Adolescents (HoNOSCA). Br J Psychiatry. 1999 May;174:413-6. doi: 10.1192/bjp.174.5.413.

  PMID: 10616607 BACKGROUND

• Skevington SM, Lotfy M, O'Connell KA; WHOQOL Group. The World Health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group. Qual Life Res. 2004 Mar;13(2):299-310. doi: 10.1023/B:QURE.0000018486.91360.00.

  PMID: 15085902 BACKGROUND

• Bernstein DP, Ahluvalia T, Pogge D, Handelsman L. Validity of the Childhood Trauma Questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):340-8. doi: 10.1097/00004583-199703000-00012.

  PMID: 9055514 BACKGROUND

• Epstein NB, Baldwin LM, Bishop DS. The McMaster Family Assessment Device. J Marital Fam Ther [Internet]. 1983 Apr;9(2):171-80. Available from: http://doi.wiley.com/10.1111/j.1752-0606.1983.tb01497.x

  BACKGROUND

• Bosc M, Dubini A, Polin V. Development and validation of a social functioning scale, the Social Adaptation Self-evaluation Scale. Eur Neuropsychopharmacol. 1997 Apr;7 Suppl 1:S57-70; discussion S71-3. doi: 10.1016/s0924-977x(97)00420-3.

  PMID: 9169311 BACKGROUND

• Beck AT, Baruch E, Balter JM, Steer RA, Warman DM. A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophr Res. 2004 Jun 1;68(2-3):319-29. doi: 10.1016/S0920-9964(03)00189-0.

  PMID: 15099613 BACKGROUND

• Singh SP, Tuomainen H, Girolamo G, Maras A, Santosh P, McNicholas F, Schulze U, Purper-Ouakil D, Tremmery S, Franic T, Madan J, Paul M, Verhulst FC, Dieleman GC, Warwick J, Wolke D, Street C, Daffern C, Tah P, Griffin J, Canaway A, Signorini G, Gerritsen S, Adams L, O'Hara L, Aslan S, Russet F, Davidovic N, Tuffrey A, Wilson A, Gatherer C, Walker L; MILESTONE Consortium. Protocol for a cohort study of adolescent mental health service users with a nested cluster randomised controlled trial to assess the clinical and cost-effectiveness of managed transition in improving transitions from child to adult mental health services (the MILESTONE study). BMJ Open. 2017 Oct 16;7(10):e016055. doi: 10.1136/bmjopen-2017-016055.

  PMID: 29042376 BACKGROUND

• Wechsler D. Wechsler adult intelligence scale, 4th ed. San Antonio, TX Pearson. 2008

  BACKGROUND

• Ryan JJ, Kreiner DS, Gontkovsky ST, Glass Umfleet L. Classification Accuracy of Sequentially Administered WAIS-IV Short Forms. Appl Neuropsychol Adult. 2015;22(6):409-14. doi: 10.1080/23279095.2014.953677. Epub 2015 Mar 18.

  PMID: 25785485 BACKGROUND

• Zimmermann P, Fimm B. Tests d'évaluation de l'attention (TEA). Würselen: Psytest. 1994

  BACKGROUND

• Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol [Internet]. 1935;18(6):643-62. Available from: http://content.apa.org/journals/xge/18/6/643

  BACKGROUND

• MacLeod CM. Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991 Mar;109(2):163-203. doi: 10.1037/0033-2909.109.2.163. No abstract available.

  PMID: 2034749 BACKGROUND

• Roussel M, Goldefroy O. La batterie GREFEX: données normatives. Fonct exécutives Pathol Neurol Psychiatr. 2008;231-52.

  BACKGROUND

• Shallice T. Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci. 1982 Jun 25;298(1089):199-209. doi: 10.1098/rstb.1982.0082.

  PMID: 6125971 BACKGROUND

• Coyette F, Van der Linden M. Adaptation de l'Épreuve de la Tour de Londres. Unpubl Doc Cent Revalidation Neuropsychol des Clin Univ Saint-Luc, Bruxelles Serv Neuropsychol l'Université Liege, Belgium. 1993

  BACKGROUND

• Gioia GA, Isquith PK. Behavior Rating Inventory for Executive Functions. In: Kreutzer JS, DeLuca J, Caplan B, editors. Encyclopedia of Clinical Neuropsychology [Internet]. New York, NY: Springer New York; 2011. p. 372-6. Available from: http://link.springer.com/10.1007/978-0-387-79948-3

  BACKGROUND

• Kermarrec S, Kabuth B, Bursztejn C, Guillemin F. French adaptation and validation of the helping alliance questionnaires for child, parents, and therapist. Can J Psychiatry. 2006 Dec;51(14):913-22. doi: 10.1177/070674370605101407.

  PMID: 17249634 BACKGROUND

• Luborsky L, Barber JP, Siqueland L, Johnson S, Najavits LM, Frank A, Daley D. The Revised Helping Alliance Questionnaire (HAq-II) : Psychometric Properties. J Psychother Pract Res. 1996 Summer;5(3):260-71.

  PMID: 22700294 BACKGROUND

• Marchini S, Reis J, Ben-Shaool E, Delhaye M, Kornreich C, Nicolis H, Slama H, Leys C, Delvenne V. Dimensional model on how familial vulnerability and environmental factors impact transitional age youth psychopathology: The Transition_psy study. Front Psychiatry. 2023 Mar 23;14:1103030. doi: 10.3389/fpsyt.2023.1103030. eCollection 2023.

  PMID: 37032919 DERIVED

• Reis J, Marchini S, De Leeuw A, Slama H, Leys C, Delhaye M, Kornreich C, Nicolis H, Delvenne V. Study Protocol: Transition_psy a Multicenter Prospective Longitudinal Cohort Study Assessing Risk and Protective Factors to Develop Psychopathology in Transitional Age Youth in Belgium. Front Psychiatry. 2021 Jun 21;12:645679. doi: 10.3389/fpsyt.2021.645679. eCollection 2021.

  PMID: 34234697 DERIVED

MeSH Terms

Conditions

Psychological Well-Being

Interventions

Risk

Condition Hierarchy (Ancestors)

Personal Satisfaction; Behavior

Intervention Hierarchy (Ancestors)

Probability; Statistics as Topic; Epidemiologic Methods; Investigative Techniques; Mathematical Concepts; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Véronique Delvenne, MD, PhD

  Queen Fabiola Children's University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 27, 2020
• First Posted: April 3, 2020
• Study Start: June 10, 2020
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: January 7, 2026

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

BE (4)