The Impact of Watermelon Juice on Blood Pressure

NCT04328311 | Unknown

• 1 other identifier: 34/19
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

L-citrulline is found naturally in watermelon. Recently interest has increased for this amino acid due to potential health benefits. Notably, L-citrulline has the potential to lead to dilation of blood vessels due to its involvement in the production of nitric oxide. The study will be an acute single blind, randomised controlled, crossover intervention study in healthy, young volunteers. Participants receive either the test watermelon drink or control drink (water). Blood samples and vascular measures (by a single-cuff based method) will be measured at baseline. Vascular measures will be repeated at 15-minute intervals between 0-2 hours and a second blood sample will be drawn at 1.5 hours to coincide with the estimated peak plasma L-citrulline. Citrulline, arginine and nitric oxide metabolites will be measured in the blood samples.

Conditions

Healthy Aging

Keywords

Watermelon; L-citrulline; Blood pressure

Outcome Measures

Primary Outcomes (1)

• Change in blood pressure

  Blood pressure by automated device

  At baseline (t= 0 hours) and 15 minute intervals until t= 2 hours.

Secondary Outcomes (3)

• Change in NOx (nitric oxide metabolites)

  At baseline (t= 0 hours) and t=1.5 hours.

• Change in l-arginine

  At baseline (t= 0 hours) and t=1.5 hours.

• Change in l-citrulline

  At baseline (t= 0 hours) and t=1.5 hours.

Study Arms (2)

Active

EXPERIMENTAL

Watermelon juice

Other: Watermelon Juice

Control

OTHER

Low nitrate water.

Other: Water

Interventions

Watermelon Juice OTHER

500 mL watermelon juice (What a Melon), containing \~1 g of L-citrulline.

Active

Water OTHER

500 mL low nitrate water

Control

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males and females
• years

You may not qualify if:

• Able to understand information sheet
• Willing to comply with the study protocol
• Able to give informed consent.
• Medical history of myocardial infarction
• Medical history of angina
• Medical history of thrombosis
• Medical history of stroke
• Medical history of cancer
• Medical history of high cholesterol
• Medical history of liver diseases
• Medical history of renal diseases
• Medical history of respiratory diseases
• Medical history of bowel diseases
• Medical history of diabetes
• Medical history of other endocrine disorders

Sponsors & Collaborators

• University of Reading: lead

Study Sites (1)

University of Reading

Reading, UK, RG6 6AH, United Kingdom

Location

MeSH Terms

Interventions

Water

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: January 7, 2020
• First Posted: March 31, 2020
• Study Start: January 8, 2020
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2024
• Last Updated: November 22, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)