Vegan and Omnivorous Diets and Skeletal Muscle Turnover in Healthy Older Adults

NCT05985369 | Completed

• 1 other identifier: 524790
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary protein intake and physical activity are key to minimise the age-related loss of skeletal muscle mass. While animal-derived protein sources are considered high-quality anabolic foods, it remains unclear whether non-animal-derived (vegan) protein sources support skeletal muscle maintenance and healthy ageing. The aim of the present study is to assess the effect of a vegan diet on daily muscle protein synthesis rates compared to a protein-matched omnivorous diet where the majority of protein is derived from high-quality animal-based protein sources.

Conditions

Healthy Aging

Keywords

Muscle metabolism; Protein metabolism; Sarcopenia; Resistance exercise

Outcome Measures

Primary Outcomes (1)

• Muscle protein synthesis (MPS) in resting and exercised tissue

  Daily MPS rates, expressed as fractional synthetic rate (%/h)

  7 days

Secondary Outcomes (1)

• Muscle morphology

  7 days

Study Arms (2)

Vegan diet

EXPERIMENTAL

Participants will be allocated to a fully controlled 1-week vegan diet containing 0.8 g/kg BW/day of protein where all protein provided will be derived from non-animal-derived protein sources.

Other: Controlled diet and resistance exercise

Omnivorous diet

EXPERIMENTAL

Participants will be allocated to a fully controlled 1-week omnivorous diet containing 0.8 g/kg BW/day of protein where the majority of protein will be derived from animal-derived protein sources.

Other: Controlled diet and resistance exercise

Interventions

Controlled diet and resistance exercise OTHER

Participants will adopt a 1-week completely controlled diet and perform 3 sessions of unilateral leg resistance exercise.

Omnivorous diet; Vegan diet

Eligibility Criteria

• Age: 60 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI between 18.5 - 30
• Active (not very sedentary and not master athlete; assessed via IPAQ)
• Women only: post menopause

You may not qualify if:

• Hypertension (\>150/90 mmHg)
• Any diagnosed metabolic impairment
• Any diagnosed cardiovascular disease
• Any diagnosed gastrointestinal disease
• Diagnosed cancer
• Any medication known to affect muscle metabolism (e.g. hormone replacement therapy)
• Severe food allergies or intolerances (e.g. celiac, lactose intolerance, allergic to fungi or algae foods)
• Smoking

Sponsors & Collaborators

• University of Exeter: lead

Study Sites (1)

University of Exeter

Exeter, Devond, EX1 2LU, United Kingdom

Location

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2023
• First Posted: August 14, 2023
• Study Start: November 9, 2022
• Primary Completion: October 31, 2023
• Study Completion: October 31, 2023
• Last Updated: April 24, 2024

Record last verified: 2024-04

Locations

GB (1)