Tumor Immune Mechanism of Axillary Lymph Node Metastasis in Early Luminal Type A Breast Cancer

NCT04322331 | Unknown

• 1 other identifier: IO Panel
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Luminal type A breast cancer is a type with good clinical prognosis, and the proportion of lymph node metastasis is low, but a small number of patients have more lymph node metastasis when the primary tumor is very small, and the survival is poor, suggesting that this part of Luminal A breast cancer has the different expression of some genes from that of general Luminal A breast cancer, which affects tumor invasion and participates in the occurrence of tumor metastasis. But the mechanism is not clear, especially in the current tumor microenvironment and immune related mechanisms.We want to investigated the relationship of the transcriptional tumor immune microenvironment with early lymph node metastasis among Luminal A type breast cancer.

Conditions

Immune Microenvironment; Luminal A; Lymph Node Metastases

Outcome Measures

Primary Outcomes (1)

• Transcriptional Characterization

  the relationship of the transcriptional tumor immune microenvironment with lymph node metastases in Luminal A breast tumor;Differences in RNA copy numbers of different genes （using IO Panel） between the two groups of patients

  2020-12

Study Arms (2)

T1N+

T1 tumor with positive lymph node,N1/N2/N3

Other: no intervention

T2/T3N0

T2/T3 tumor with negative lymph node

Other: no intervention

Interventions

no intervention OTHER

no intervention

T1N+; T2/T3N0

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

invasive breast cancer patients with Luminal A type. Stage T1N1/T1N2/T1N3 are in group 1; stage T2N0/T3N0 are in group 2

You may qualify if:

• invasive breast cancer with Luminal A type;T1 with positive lymph node or T2/T3 with negative lymph node

You may not qualify if:

• Missing specimen

Sponsors & Collaborators

• Peking University People's Hospital: lead

Study Sites (1)

Peking university people's hospital

Beijing, China

Location

MeSH Terms

Conditions

Lymphatic Metastasis

Condition Hierarchy (Ancestors)

Neoplasm Metastasis; Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2020
• First Posted: March 26, 2020
• Study Start: May 1, 2020
• Primary Completion: May 1, 2021
• Study Completion: December 31, 2021
• Last Updated: March 31, 2020

Record last verified: 2020-03

Locations

CN (1)