Targeting Taboo Thoughts In Obsessive-Compulsive Disorder

NCT04313439 | Completed

• 1 other identifier: EPN Dnr 2019-06047
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this pilot study is to investigate if a cognitive treatment targeting obsessive beliefs in patients with aggressive obsessions is feasible and effective as an online treatment.

Conditions

Obsessive-Compulsive Disorder

Keywords

Obsessions; Cognitive therapy; Internet

Outcome Measures

Primary Outcomes (1)

• The clinician rated Yale Brown Obsessive Compulsive Scale (Y-BOCS)

  Change in obsessions and compulsions from baseline to week 10 and 6 months after treatment has ended. Minimum value is 0. Maximum value is 40. Higher score means more symptoms.

  Week 0, week 10, and 6 months follow up

Secondary Outcomes (10)

• The self-rated Yale Brown Obsessive Compulsive Scale (Y-BOCS)

  Weeks 0 to 10 through treatment and 6 months follow-up

• Personal Significance Scale (PSS)

  Weeks 0 to 10 through treatment and 6 months follow-up

• Montgomery Åsberg Depression Rating Scale - Self report (MADRS-S)

  Week 0, week 10 and 6 months follow-up

• Clinical Global Impression (CGI)

  Week 0, week 10 and 6 months follow-up

• Work and social adjustment scale (WSAS)

  Week 0, week 10 and 6 months follow-up

Study Arms (1)

Treatment

EXPERIMENTAL

Online Cognitive Therapy (I-CT)

Other: Online cognitive therapy (I-CT)

Interventions

Online cognitive therapy (I-CT) OTHER

The treatment is an online cognitive therapy consisting of a structured self-help program over ten weeks, divided into eight modules, administered in an encrypted web platform. The program is based on the treatment manual "The treatment of Obsessions" by Stanley Rachman. In this treatment, the participant is recommended to perform daily exercises in order to identify and modify interpretations made about the importance of their obsessive thoughts. A designated therapist have email contact with the participant within the encrypted platform.

Treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of OCD taboo thoughts as specified in the DSM-5
• ≥ 18 years
• Situated in Sweden
• Informed consent

You may not qualify if:

• No signed consent
• Not fluent speaking in Swedish or cognitive abilities to read written material in the study
• Adjusted pharmacological treatment the last month symptoms that may affect OCD symptoms
• Substance dependence during the last six months
• Psychosis
• Ongoing mania or hypomania
• Suicidal risk that may affect study participation
• Personality disorder that may significantly affect the treatment participation
• Other ongoing psychological treatments that may affect OCD-symptoms
• Other primary psychiatric diagnosis

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Stockholm, 17177, Sweden

Location

MeSH Terms

Conditions

Obsessive-Compulsive Disorder; Obsessive Behavior

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Officials

• Erik Andersson, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: March 12, 2020
• First Posted: March 18, 2020
• Study Start: March 26, 2020
• Primary Completion: February 15, 2021
• Study Completion: August 11, 2021
• Last Updated: August 17, 2021

Record last verified: 2021-08

Locations

SE (1)