NCT04306770

Brief Summary

OPTIMUM study aims to use the telehealth-enabled chronic disease management programme for individuals with chronic diseases to provide timely intervention to prevent disease deterioration, increase compliance to treatment regimen (e.g. medication), and most importantly, engage participants to better manage their own care.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
330

participants targeted

Target at P75+ for not_applicable diabetes-mellitus

Timeline
Completed

Started Jan 2020

Typical duration for not_applicable diabetes-mellitus

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 20, 2020

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

March 6, 2020

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 13, 2020

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2022

Completed
Last Updated

March 13, 2020

Status Verified

March 1, 2020

Enrollment Period

2.4 years

First QC Date

March 6, 2020

Last Update Submit

March 10, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Diabetic control

    HbA1c (in percentage)

    6 months

Secondary Outcomes (11)

  • Diabetic control

    12 months, 24 months

  • Blood pressure control

    6 months, 12 months, 24 months

  • Optimal weight control

    6 months, 12 months, 24 months

  • Utility Score

    6 months, 12 months, 24 months

  • Diabetic medication adherence 9 Diabetic medication adherence (Oral Hypoglycemia agent)

    6 months, 12 months, 24 months

  • +6 more secondary outcomes

Study Arms (2)

Intervention

ACTIVE COMPARATOR

OPTIMUM Programme

Other: OPTIMUM programme

Control

NO INTERVENTION

Treatment as usual

Interventions

OPTIMUM programme encompass of telehealth service to support the patient. Study participants will be given devices (Bluetooth-enabled blood pressure machine, weighing scale and glucometer) to monitor their parameters at home. Care team will use the Phillips "Vital Health" to perform tele-monitoring, tele-management (individualized on-line health coaching and timely interventions), and to deliver education content.

Intervention

Eligibility Criteria

Age26 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Singapore Citizen or Permanent Resident
  • \. Age 26 - 65 years (latest age of entry for insurance coverage is 65 at next birthday)
  • \. Type 2 Diabetes Mellitus (HbA1c ≤ 10% and ≥ 7.5% per latest reading) with and without the following complications:
  • Mild non-proliferative diabetic retinopathy without any macular or retinal involvement;
  • Chronic Kidney Diseases up to stage 3
  • \. Patients registered with participating polyclinic
  • \. Non-smoker, or ex-smoker who has completely quit smoking for at least 12 months
  • \. Existing user of smartphone and is willing to download the relevant mobile application (iPhone or Android phones are acceptable)
  • \. Expressed willingness to use the telehealth system and devices according to study protocol during the study period

You may not qualify if:

  • Poorly controlled glycemic control with HbA1c \> 10% (latest reading)
  • Cognitively impaired based on diagnosis of dementia or mild cognitive impairment (MCI) in the electronic health records (EHR)
  • Existing conditions listed below, as documented in the EHR:
  • Any proliferative diabetic retinopathy (moderate to severe) and any macular or other retinal complications;
  • Chronic kidney disease Stage 4 or 5;
  • Coronary arterial diseases.
  • Cerebrovascular diseases such as transient ischemic attach (TIA) or stroke;
  • Peripheral vascular disease (result from diabetic foot screening);
  • Known cognitive impairment, including MCI
  • Not able to use smartphone despite coaching
  • Any end-stage disease with life prognosis of \< 2 year
  • Patients who are not willing or are not able to commit to the entire Optimum program
  • Pregnant women
  • Currently enrolled in another study / programme involving a novel therapeutic drug or device

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sengkang Polyclinic

Singapore, 545025, Singapore

RECRUITING

Related Publications (3)

  • Berkel C van, Smith M, Horsfield D, McManus H. Evidence for Supported Self-Care at Scale. International Journal of Integrated Care. 2016 Nov 9;16(5):S44.

    BACKGROUND
  • Tan NC, Gong PP, Lee CS, Goh SKL, Ang SB, Koh GCH. Theory-based behaviour modification of Asian adults with type-2 diabetes mellitus after participating in a novel telemonitoring system: a qualitative research study. BMJ Open. 2024 Dec 23;14(12):e080830. doi: 10.1136/bmjopen-2023-080830.

  • Goh KLS, Lee CS, Koh CHG, Ling NL, Ang SB, Oh C, Lin Y, Yuan W, Zheng QC, Tan NC. Evaluating the effectiveness and utility of a novel culturally-adapted telemonitoring system in improving the glycaemic control of Asians with type-2 diabetes mellitus: a mixed method study protocol. Trials. 2021 Apr 26;22(1):305. doi: 10.1186/s13063-021-05240-6.

Related Links

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Ngiap Chuan Tan, FCFPS

    SingHealth Polyclinics

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 6, 2020

First Posted

March 13, 2020

Study Start

January 20, 2020

Primary Completion

July 1, 2022

Study Completion

July 1, 2022

Last Updated

March 13, 2020

Record last verified: 2020-03

Data Sharing

IPD Sharing
Will not share

Locations