NCT04290702

Brief Summary

The three standard techniques used for labor analgesia, thus epidural, combined spinal-epidural and dural puncture epidural will be compared regarding their impact on pain intensity, analgesic and local anesthetic consumption and course of vaginal delivery in a prospective, randomised, double blind manner

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2020

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 19, 2020

Completed
1 month until next milestone

Study Start

First participant enrolled

February 26, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 2, 2020

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2021

Completed
Last Updated

March 5, 2020

Status Verified

March 1, 2020

Enrollment Period

1.8 years

First QC Date

January 19, 2020

Last Update Submit

March 4, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • analgesic consumption

    the amount of local anesthetic and opioid that required during labor

    during the procedure/delivery

Secondary Outcomes (3)

  • pain intensity on a numerical rating scale (minimum=0, maximum=10)

    during the procedure/delivery

  • duration of labor

    until delivery

  • satisfaction on a numerical rating scale (minimum=0, maximum=10)

    during the procedure/delivery

Study Arms (3)

epidural

ACTIVE COMPARATOR
Procedure: regional analgesia for labor

combined

ACTIVE COMPARATOR
Procedure: regional analgesia for labor

dural puncture epidural

ACTIVE COMPARATOR
Procedure: regional analgesia for labor

Interventions

three commonly used regional analgesic techniques are used, with local anesthetic ropivacaine, opioid fentanyl, parturient controlled epidural analgesia

combineddural puncture epiduralepidural

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • parturients requiring regional labor analgesia
  • dilation less than 5cm

You may not qualify if:

  • contraindication for regional technique
  • refuse to participate
  • language barriers
  • obesity
  • no pain

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Aretaieio Hospital, University of Athens

Athens, Attica, 11528, Greece

RECRUITING

Aretaieio Hospital

Athens, Greece

RECRUITING

MeSH Terms

Conditions

Labor PainAgnosia

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsPerceptual DisordersNeurobehavioral ManifestationsNervous System Diseases

Central Study Contacts

Chyrssoula Staikou, Assoc Prof

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: 3 groups with different regional analgesic technique
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

January 19, 2020

First Posted

March 2, 2020

Study Start

February 26, 2020

Primary Completion

December 1, 2021

Study Completion

December 1, 2021

Last Updated

March 5, 2020

Record last verified: 2020-03

Locations