NCT04288011|Terminated
Study Stopped
Study was ended because of COVID19. Patients did not want to come to hospital for continued participation
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Study was ended because of COVID19. Patients did not want to come to hospital for continued participation
Sponsor study identifier
observational
30
1 country
1
Study Start
February 26, 2021
Actual (reported)Primary Completion
December 20, 2022
Actual (reported)Study Completion
February 20, 2023
Actual (reported)This study involves data collection from use of the BeCare Link LLC mobile device app by subjects with Multiple Sclerosis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 20, 2023
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 22, 2020
Actual (reported)February 27, 2020
Actual (reported)February 26, 2021
Actual (reported)December 20, 2022
Actual (reported)February 20, 2023
Actual (reported)Clinical EDSS score vs MLA EDSS score comparison
To assess the efficacy of using a mobile application to perform routine assessments of neurological and physical functioning in subjects with MS by comparing clinically assigned EDSS scores with EDSS scores assigned by a single or multiple artificial intelligence techniques at various timed intervals
day 1 (initial visit)
Clinical EDSS score vs MLA EDSS score comparison
To assess the efficacy of using a mobile application to perform routine assessments of neurological and physical functioning in subjects with MS by comparing clinically assigned EDSS scores with EDSS scores assigned by a single or multiple artificial intelligence techniques at various timed intervals
90 days after day 1
Clinical EDSS score vs MLA EDSS score comparison
To assess the efficacy of using a mobile application to perform routine assessments of neurological and physical functioning in subjects with MS by comparing clinically assigned EDSS scores with EDSS scores assigned by a single or multiple artificial intelligence techniques at various timed intervals
180 days after day 1
Disease Progression Measured by Change in EDSS score
weekly for 26 weeks
Development of a novel application to measure change in MS
18 months
The Kurtzke EDSS, is a clinical rating scale for multiple sclerosis having scores between 0 to 10 that are assigned by a trained clinician. Smaller impairments are assessed at lower scores and disability is assessed at higher scores. It is important to note, however, that despite being denoted on an ordinal scale, each level on the scale is not indicative of an equal change in disability.
The Kurtzke EDSS, is a clinical rating scale or multiple sclerosis having scores between 0 to 10 that are assigned by a technique based upon several different Machine Learning Algorithms that are combined to produce a single score
Patients with mild to moderate Multiple Sclerosis that can use a mobile app and are ambulatory.
Yale University School of Medicine
New Haven, Connecticut, 06520, United States
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O'Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 Feb;69(2):292-302. doi: 10.1002/ana.22366.
Sebastiao E, Sandroff BM, Learmonth YC, Motl RW. Validity of the Timed Up and Go Test as a Measure of Functional Mobility in Persons With Multiple Sclerosis. Arch Phys Med Rehabil. 2016 Jul;97(7):1072-7. doi: 10.1016/j.apmr.2015.12.031. Epub 2016 Mar 2.
Sharon Stoll, DO,MS
Yale University
30 participants (actual enrollment reported by the registry).
First Submitted
February 22, 2020
First Posted
February 27, 2020
Study Start
February 26, 2021
Actual (reported)Low Load Resistance Training Using Blood Flow Restriction for People With Multiple Sclerosis
Contact the study team to confirm eligibility.
Berrigan LI, Fisk JD, Walker LA, Wojtowicz M, Rees LM, Freedman MS, Marrie RA. Reliability of regression-based normative data for the oral symbol digit modalities test: an evaluation of demographic influences, construct validity, and impairment classification rates in multiple sclerosis samples. Clin Neuropsychol. 2014;28(2):281-99. doi: 10.1080/13854046.2013.871337. Epub 2014 Jan 20.
Primary Completion
December 20, 2022
Actual (reported)Study Completion
February 20, 2023
Actual (reported)Last Updated
September 30, 2026
Record last verified: 2026-09
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Source: ClinicalTrials.gov.
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