NCT04280783

Brief Summary

Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them. In recent years, many studies have used the internet to promote PA in many settings, including the home environment, but only a few studies have recruited AAs. Without innovative and culturally relevant interventions, AAs will continue reporting extremely low levels of PA and disparate cardiovascular health outcomes. In prior work, the investigators sought the input of AA focus groups to inform the development of a technology-based Physical Activity for The Heart (PATH) intervention that leverages openly accessible platforms, such as YouTube, to promote PA in any setting. The investigators designed PATH as a culturally salient action-oriented intervention that can be accessed in any setting to promote PA among inactive AAs. In this application, the investigators propose to examine whether PATH is a feasible strategy for promoting PA among inactive AAs. In Aim 1 the investigators will conduct a randomized clinical trial that will include 30 inactive AAs to assess the feasibility and acceptability of the PATH intervention. In Aim 2 the investigators will examine the trend in PA and cardiovascular disease risk change from baseline to post-intervention. This approach is innovative because it leverages openly accessible technologies to provide a wide variety of free, enjoyable and action-oriented workout videos that match AAs preferences. This contribution will be significant because PATH could offer a novel, low-cost, and scalable strategy for promoting PA among individuals facing socio-environmental barriers to PA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2020

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 19, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 21, 2020

Completed
8 months until next milestone

Study Start

First participant enrolled

October 27, 2020

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2021

Completed
1.9 years until next milestone

Results Posted

Study results publicly available

December 4, 2023

Completed
Last Updated

November 5, 2024

Status Verified

October 1, 2024

Enrollment Period

1.2 years

First QC Date

February 19, 2020

Results QC Date

July 21, 2023

Last Update Submit

October 14, 2024

Conditions

Keywords

Physical activityWeb-basedYouTubeRemote

Outcome Measures

Primary Outcomes (3)

  • Percentage of Participants Retained at the End of Study

    Will be indicated by the number of enrolled participants who are retained by the end of the study.

    Post-intervention at 12 weeks

  • Percentage of Participants Who Self-monitored Step Count Using Wrist Worn ActiGraph GT9X Over the Study Period

    will be indicated by the proportion of the sample with ≥4days per week of valid Actigraph wear time (≥10hrs) during the entire course of the study.

    Post-intervention at 12 weeks

  • Acceptability of PATH Intervention

    Percentage of participants who reported the PATH platform was culturally appropriate

    Post-intervention at 12 weeks

Secondary Outcomes (10)

  • Body Mass Index (BMI) at 12 Weeks

    Post-intervention at 12 weeks

  • Change From Baseline in Body Fat Percentage at 12 Weeks

    Post-intervention at 12 weeks

  • Change From Baseline in Waist Circumference at 12 Weeks

    Post-intervention at 12 weeks

  • Change From Baseline in Systolic Blood Pressure (SBP) at 12 Weeks

    Post-intervention at 12 weeks

  • Change From Baseline in Glycated Hemoglobin (HbA1C) at 12 Weeks

    Post-intervention at 12 weeks

  • +5 more secondary outcomes

Other Outcomes (1)

  • Change From Baseline in Light Physical Activity at 12 Weeks

    Post-intervention at 12 weeks

Study Arms (2)

PATH Treatment Group

EXPERIMENTAL

The PATH group will be granted password protected access to one of the 3 PATH levels based on their baseline fitness status. The intervention is designed to help participants increase their baseline PA via health coaching, self-monitoring and pragmatic workout videos that provide convenient options for overcoming socio-environmental barriers to PA.

Behavioral: The Physical Activity for The Heart (PATH) intervention

Wait-list control group

OTHER

Participants in this group will not have access to the PATH intervention until after 12 weeks when they cross over. After randomization, the control group will be provided with a copy of the Be Active Your Way booklet, developed by the Centers for Disease Control (CDC) to help individuals integrate PA in their daily lives.

Behavioral: Be Active Your Way Booklet

Interventions

The web-based Physical Activity for The Heart (PATH) intervention leverages openly accessible platforms, such as YouTube, to proffer workout videos that match the participants preferences. Currently, PATH includes over 90 workout videos vetted by a team of experts and curated on the PATH website in 3 controlled levels of intensity (beginner, intermediate, proficient) to foster gradual progression from low to high intensity PA in accordance with the FITT-VP (frequency, intensity, time, type, volume, progression) principle.

PATH Treatment Group

Be Active Your Way booklet was developed by the Centers for Disease Control (CDC) to help individuals integrate PA in their daily lives. It simply encourages individuals to increase their PA gradually and gives them examples of things that they can do.

Wait-list control group

Eligibility Criteria

Age40 Years - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years old
  • BMI≥25
  • Have regular access to the internet (via computer or smart phone)
  • Less than 90 mins of self-reported moderate to vigorous physical activity per week
  • American Diabetes Association (ADA) risk ≥5
  • Available for pre and post-intervention assessments.
  • Self-identify as Black/African American

You may not qualify if:

  • Unstable conditions that may require supervised PA
  • Physical limitations that may prohibit engagement in MVPA
  • Pregnancy or intention to become pregnant during study, history of CVD
  • Current participation in a PA study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Primay Health Network

Beaver Falls, Pennsylvania, 15010, United States

Location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15261, United States

Location

Related Publications (1)

  • Kariuki JK, Sereika S, Erickson K, Burke LE, Kriska A, Cheng J, Milton H, Hirshfield S, Ogutu D, Gibbs B. Feasibility and preliminary efficacy of a novel web-based physical activity intervention in adults with overweight/obesity: A pilot randomized controlled trial. Contemp Clin Trials. 2023 Oct;133:107318. doi: 10.1016/j.cct.2023.107318. Epub 2023 Aug 23.

MeSH Terms

Conditions

Prediabetic StateOverweightObesitySedentary BehaviorMotor Activity

Interventions

Methods

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior

Intervention Hierarchy (Ancestors)

Investigative Techniques

Limitations and Caveats

The short study length and small sample size limit our ability to test effectiveness; however, as our study was meant to demonstrate feasibility and acceptability, in line with the ORBIT model, this is appropriate for the formative phase of behavioral intervention development.

Results Point of Contact

Title
Dr. Jacob Kariuki
Organization
Emory University

Study Officials

  • Jacob Kariuki, PhD

    University of Pittsburgh

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: We will randomize 30 participants to either the PATH treatment group or wait-list control group.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

February 19, 2020

First Posted

February 21, 2020

Study Start

October 27, 2020

Primary Completion

December 31, 2021

Study Completion

December 31, 2021

Last Updated

November 5, 2024

Results First Posted

December 4, 2023

Record last verified: 2024-10

Data Sharing

IPD Sharing
Will share

It is our goal to make all data generated from this proposal available to other investigators without compromising the confidentiality of participants. Investigators who would like to do a secondary analysis of de-identified data can submit a formal request for the data including the proposal of their intended analysis to the PI at activeu@pitt.edu. The PI will review all requests and facilitate data access once approval is granted.

Shared Documents
SAP, CSR
Time Frame
12 months after the end of the study
Access Criteria
Data access will be provided based on scientific merit of the proposed analysis, IRB approval and data agreement contract as deemed appropriate by University of Pittsburgh

Locations