Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age

NCT04280367 | Completed

• 2 other identifiers: APHP1910932019-A02663-54
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning disorders (by two types: patients with other neuro-developmental disorders including executive function disorders, and patients with anxiety).

Conditions

Schizophrenia; Learning Disorders; Executive Function Disorders

Keywords

learning disorders; executive function disorders; psychosis; children; adult-age

Outcome Measures

Primary Outcomes (1)

• Semi-structured interview

  Assessement with Comprehensive Assessment of At-Risk Mental States (CAARMS) during 6 to 90 minutes at the center of Raymond Poincaré hospital. The unique collection during the interview, quotation of each patient will be given from the assessement. There will be 4 groups by the results: CAARMS negative subjects, vulnerable subjects, attenuated psychosis subjects and subjects with brief and limited intermittent psychotic syndrome. The further statistic comparison will be done between the 3 last groups classified with results of CAARMS.

  At baseline

Secondary Outcomes (3)

• Autistic screening

  At baseline

• Anxiety measuring

  At baseline

• Social interaction difficulty evaluation

  At baseline

Study Arms (3)

Comparator group

Specific learning disorders group

Diagnostic Test: Standardised semi-structured talk; Diagnostic Test: Autistic spectre disorder screening; Diagnostic Test: Anxiety measuring

neuro-developmental complexed group

Group of neuro-developmental complexe of learning

Diagnostic Test: Standardised semi-structured talk; Diagnostic Test: Autistic spectre disorder screening; Diagnostic Test: Anxiety measuring

Complexed with anxiety

Disorders in learning with anxiety

Diagnostic Test: Standardised semi-structured talk; Diagnostic Test: Autistic spectre disorder screening; Diagnostic Test: Anxiety measuring

Interventions

Standardised semi-structured talk DIAGNOSTIC_TEST

Comprehensive assessment of at-risk mental states (CAARMS) will be used.

Comparator group; Complexed with anxiety; neuro-developmental complexed group

Autistic spectre disorder screening DIAGNOSTIC_TEST

Autism-spectrum quotient (AQ) auto-questionnaire will be used.

Comparator group; Complexed with anxiety; neuro-developmental complexed group

Anxiety measuring DIAGNOSTIC_TEST

An inventory for measuring clinical anxiety: Beck Anxiety Inventory (BAI); Liebowitz Social Anxiety Scale.

Comparator group; Complexed with anxiety; neuro-developmental complexed group

Eligibility Criteria

• Age: 15 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients between 15 and 30 years, suffering learning disorders complicated with two orders: with other neuro-developmental, or with anxiety (vs specific: comparator group).

You may qualify if:

• Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the center of language and learning disorders at Raymond Poincaré hospital;
• With severe learning disorders: deficiency in school work, need at least one medical appointment and long-term rehabilitation in the center of language and learning disorders at Raymond Poincaré hospital;
• Affiliated to a social protection schema;
• Written informed consent signed.

You may not qualify if:

• Absence of learning disorder;
• Intellectual deficiency;
• Epilepsia;
• Patients who will performed follow-up at Chartres city;
• Patients under guardianship or curatorship;
• Foreign patients under AME schema, a medical help from the state in France.

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré

Garches, 92380, France

Location

MeSH Terms

Conditions

Schizophrenia; Learning Disabilities; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders

Study Officials

• Emilie SCHLUMBERGER, MD

  Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP

  PRINCIPAL INVESTIGATOR

• Albane Mansoux

  Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 20, 2020
• First Posted: February 21, 2020
• Study Start: January 28, 2020
• Primary Completion: May 29, 2020
• Study Completion: May 29, 2020
• Last Updated: August 22, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)