NCT04251052

Brief Summary

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,956

participants targeted

Target at P75+ for not_applicable

Timeline
258mo left

Started Sep 2020

Longer than P75 for not_applicable

Geographic Reach
3 countries

549 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress21%
Sep 2020Jun 2047

First Submitted

Initial submission to the registry

January 14, 2020

Completed
17 days until next milestone

First Posted

Study publicly available on registry

January 31, 2020

Completed
7 months until next milestone

Study Start

First participant enrolled

September 1, 2020

Completed
26.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2047

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2047

Last Updated

March 27, 2026

Status Verified

March 1, 2026

Enrollment Period

26.8 years

First QC Date

January 14, 2020

Last Update Submit

March 23, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time to development of incident high-grade serous carcinomas (HGSC), specifically ovarian, primary peritoneal, or fallopian tube cancers

    Will be assessed using a stratified log rank test, stratifying for age. The effects of other covariates, such as familial history of gynecologic cancer, time to crossover for bilateral salpingectomy (BLS) patients, and age at study entry, will be adjusted for in Cox proportional hazard models. Patients who crossover will be analyzed according to the initial surgery received at study enrollment as this will reflect actual practice.

    Up to 20 years

Secondary Outcomes (7)

  • Health-related quality of life (QOL)

    Up to 24 months post-surgery

  • Cancer distress

    Up to 24 months post-surgery

  • Medical decision making

    Up to 24 months post-surgery

  • Incidence of adverse events

    Up to 20 years

  • Estrogen deprivation symptoms (pre-menopaused patients only)

    Up to 24 months post-surgery

  • +2 more secondary outcomes

Other Outcomes (4)

  • Cost effectiveness

    Up to 24 months post-surgery

  • Sexual dysfunction (pre-menopausal patients only)

    Up to 24 months-post surgery

  • Health related (HR)-QOL

    Up to 24 months post-surgery

  • +1 more other outcomes

Study Arms (2)

Group I (bilateral salpingectomy)

EXPERIMENTAL

Patients undergo bilateral salpingectomy. Patients may then undergo oophorectomy after initial surgery. Patients also undergo a pelvic or transvaginal ultrasound or pelvic MRI during screening and blood sample collection throughout the trial.

Procedure: Bilateral SalpingectomyProcedure: Biospecimen CollectionProcedure: Magnetic Resonance ImagingOther: Quality-of-Life AssessmentOther: Questionnaire AdministrationProcedure: Transvaginal UltrasoundProcedure: Ultrasound Imaging

Group II (bilateral salpingo-oophorectomy)

ACTIVE COMPARATOR

Patients undergo bilateral salpingo-oophorectomy. Patients also undergo a pelvic or transvaginal ultrasound or pelvic MRI during screening and blood sample collection throughout the trial.

Procedure: Bilateral Salpingectomy with OophorectomyProcedure: Biospecimen CollectionProcedure: Magnetic Resonance ImagingOther: Quality-of-Life AssessmentOther: Questionnaire AdministrationProcedure: Transvaginal UltrasoundProcedure: Ultrasound Imaging

Interventions

Undergo bilateral salpingectomy

Group I (bilateral salpingectomy)

Undergo bilateral salpingo-oophorectomy

Also known as: bilateral salpingo-oophorectomy
Group II (bilateral salpingo-oophorectomy)

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection
Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Undergo pelvic MRI

Also known as: Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI
Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Ancillary studies

Also known as: Quality of Life Assessment
Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Ancillary studies

Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Undergo transvaginal ultrasound

Also known as: transvaginal sonography, TVS, TVU
Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Undergo pelvic ultrasound

Also known as: 2-Dimensional Grayscale Ultrasound Imaging, 2-Dimensional Ultrasound Imaging, 2D-US, Ultrasonography, Ultrasound, Ultrasound Test, Ultrasound, Medical, US
Group I (bilateral salpingectomy)Group II (bilateral salpingo-oophorectomy)

Eligibility Criteria

Age35 Years - 50 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Individuals 35-50 years of age, inclusive
  • Patients who will undergo risk-reducing salpingo-oophorectomy (RRSO) (for the BSO arm) and patients who have declined or elected to defer BSO after proper counselling to clearly explain the standard of care for BRCA1 mutation carriers and are undergoing salpingectomy (for the BLS arm with delayed oophorectomy arm). Concurrently planned hysterectomy with either arm is permitted
  • At least one intact ovary and fallopian tube is in situ at the time of counseling, consent, and registration. Prior hysterectomy is allowed provided it did not include bilateral salpingectomy. Prior tubal ligation is allowed if one ovary and fallopian tube (with fimbria not removed) are present
  • Positive Clinical Laboratory Improvement Act (CLIA)-approved test results for pathogenic or likely pathogenic germline BRCA1 mutation in the patient. Documentation of the result is required
  • Patients may be premenopausal or menopausal
  • Pelvic ultrasound (transvaginal imaging preferred, but transabdominal imaging is acceptable) or pelvic MRI and CA-125 within 180 days of registration
  • The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
  • Individuals who are currently pregnant or plan to become pregnant in the future through assisted reproductive technologies and who have received proper counseling are eligible. Individuals who are currently pregnant and plan bilateral salpingectomy at the time of a planned cesarean section are eligible. Patients must understand that they will not be able to become pregnant naturally in the future

You may not qualify if:

  • Individuals with a history of any prior cancer who have received cytotoxic chemotherapy within the past 30 days or radiotherapy to abdomen or pelvis at any prior time. Endocrine therapy or maintenance ERBB2/HER2 targeted therapy is allowed. Maintenance immune checkpoint inhibitor therapy is allowed. Maintenance therapy with PARP in inhibitor is allowed.
  • Prior history of ovarian cancer, including low malignant potential neoplasms (LMP), primary peritoneal carcinoma, or fallopian tube carcinoma
  • Patients medically unfit for the planned surgical procedure
  • Patients with abnormal screening tests (pelvic ultrasound, pelvic MRI, CA-125) suspicious for occult or gross pelvic malignancy within the past 180 days
  • An abnormal CA-125 is defined as a level \> 50U/ml in premenopausal individuals if they are not current users of oral contraceptives; an abnormal CA-125 is defined as a level \> 40U/ml for premenopausal individuals who are current users of oral contraceptives (Skates 2011). An abnormal CA-125 is defined as a level \> 35 U/ml in postmenopausal individuals

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (549)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

RECRUITING

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States

RECRUITING

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States

SUSPENDED

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States

RECRUITING

Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States

RECRUITING

Katmai Oncology Group

Anchorage, Alaska, 99508, United States

RECRUITING

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

RECRUITING

CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States

ACTIVE NOT RECRUITING

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States

RECRUITING

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States

RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

RECRUITING

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States

RECRUITING

Tower Cancer Research Foundation

Beverly Hills, California, 90211, United States

SUSPENDED

Keck Medicine of USC Buena Park

Buena Park, California, 90621, United States

RECRUITING

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States

RECRUITING

Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States

RECRUITING

Mercy San Juan Medical Center

Carmichael, California, 95608, United States

RECRUITING

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States

RECRUITING

Kaiser Permanente Dublin

Dublin, California, 94568, United States

RECRUITING

Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States

RECRUITING

Kaiser Permanente-Fremont

Fremont, California, 94538, United States

RECRUITING

Fresno Cancer Center

Fresno, California, 93720, United States

SUSPENDED

Kaiser Permanente Fresno Orchard Plaza

Fresno, California, 93720, United States

RECRUITING

Kaiser Permanente-Fresno

Fresno, California, 93720, United States

RECRUITING

City of Hope Seacliff

Huntington Beach, California, 92648, United States

RECRUITING

Keck Medicine of USC Huntington Beach

Huntington Beach, California, 92648, United States

RECRUITING

City of Hope at Irvine Lennar

Irvine, California, 92618, United States

RECRUITING

Kaiser Permanente-Irvine

Irvine, California, 92618, United States

RECRUITING

City of Hope Antelope Valley

Lancaster, California, 93534, United States

RECRUITING

Keck Medicine of USC Koreatown

Los Angeles, California, 90020, United States

RECRUITING

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States

RECRUITING

Los Angeles General Medical Center

Los Angeles, California, 90033, United States

RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

RECRUITING

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States

RECRUITING

Kaiser Permanente- Modesto MOB II

Modesto, California, 95356, United States

RECRUITING

Kaiser Permanente-Modesto

Modesto, California, 95356, United States

RECRUITING

Providence Queen of The Valley

Napa, California, 94558, United States

RECRUITING

USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, 92663, United States

RECRUITING

Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States

SUSPENDED

Kaiser Permanente-Oakland

Oakland, California, 94611, United States

RECRUITING

Kaiser Permanente - Panorama City

Panorama City, California, 91402, United States

RECRUITING

Huntington Memorial Hospital

Pasadena, California, 91105, United States

RECRUITING

Keck Medical Center of USC Pasadena

Pasadena, California, 91105, United States

RECRUITING

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States

SUSPENDED

Kaiser Permanente- Marshall Medical Offices

Redwood City, California, 94063, United States

RECRUITING

Kaiser Permanente-Redwood City

Redwood City, California, 94063, United States

RECRUITING

Kaiser Permanente-Richmond

Richmond, California, 94801, United States

RECRUITING

Kaiser Permanente-Riverside

Riverside, California, 92505, United States

RECRUITING

Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States

RECRUITING

Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States

SUSPENDED

Kaiser Permanente-Roseville

Roseville, California, 95661, United States

RECRUITING

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States

SUSPENDED

Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States

RECRUITING

Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States

RECRUITING

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

RECRUITING

Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States

RECRUITING

South Sacramento Cancer Center

Sacramento, California, 95823, United States

SUSPENDED

Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States

RECRUITING

UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States

RECRUITING

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States

RECRUITING

Kaiser Permanente San Leandro

San Leandro, California, 94577, United States

RECRUITING

Kaiser San Rafael-Gallinas

San Rafael, California, 94903, United States

RECRUITING

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States

RECRUITING

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States

RECRUITING

Providence Medical Foundation - Santa Rosa

Santa Rosa, California, 95403, United States

RECRUITING

Providence Santa Rosa Memorial Hospital

Santa Rosa, California, 95405, United States

RECRUITING

City of Hope South Pasadena

South Pasadena, California, 91030, United States

RECRUITING

Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080, United States

SUSPENDED

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States

RECRUITING

Kaiser Permanente-Stockton

Stockton, California, 95210, United States

RECRUITING

City of Hope South Bay

Torrance, California, 90503, United States

RECRUITING

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505, United States

RECRUITING

City of Hope Upland

Upland, California, 91786, United States

RECRUITING

Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States

RECRUITING

Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States

RECRUITING

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States

RECRUITING

Woodland Memorial Hospital

Woodland, California, 95695, United States

RECRUITING

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

RECRUITING

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

SUSPENDED

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States

RECRUITING

Memorial Hospital North

Colorado Springs, Colorado, 80920, United States

RECRUITING

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129, United States

RECRUITING

Longmont United Hospital

Longmont, Colorado, 80501, United States

SUSPENDED

Danbury Hospital

Danbury, Connecticut, 06810, United States

RECRUITING

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830, United States

RECRUITING

Hartford Hospital

Hartford, Connecticut, 06102, United States

RECRUITING

The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States

RECRUITING

Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States

RECRUITING

Yale University

New Haven, Connecticut, 06520, United States

RECRUITING

Norwalk Hospital

Norwalk, Connecticut, 06856, United States

RECRUITING

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States

RECRUITING

Beebe Medical Center

Lewes, Delaware, 19958, United States

SUSPENDED

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States

SUSPENDED

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

RECRUITING

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

SUSPENDED

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States

RECRUITING

Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States

SUSPENDED

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, 19801, United States

RECRUITING

George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States

SUSPENDED

UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States

RECRUITING

Florida Cancer Specialists - Bradenton Cancer Center

Bradenton, Florida, 34205, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Doral

Doral, Florida, 33166, United States

RECRUITING

Florida Cancer Specialists-Englewood

Englewood, Florida, 34223, United States

RECRUITING

GenesisCare USA - FGO

Fort Myers, Florida, 33905, United States

SUSPENDED

Regional Cancer Center-Lee Memorial Health System

Fort Myers, Florida, 33905, United States

SUSPENDED

UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States

RECRUITING

Jackson Memorial Hospital-Holtz Children's Hospital

Miami, Florida, 33136, United States

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States

RECRUITING

Sarasota Memorial Hospital-Venice

Nokomis, Florida, 34275, United States

RECRUITING

University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

North Miami, Florida, 33181, United States

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States

RECRUITING

Florida Cancer Specialists - Sarasota

Sarasota, Florida, 34232, United States

RECRUITING

Intercoastal Medical Group - Cattleridge II

Sarasota, Florida, 34232, United States

RECRUITING

Florida Cancer Specialists - Sarasota Downtown

Sarasota, Florida, 34236, United States

RECRUITING

First Physicians Group - Gastroenterology Obesity Medicine

Sarasota, Florida, 34239, United States

RECRUITING

First Physicians Group - Silverstein Institute at Floyd Street

Sarasota, Florida, 34239, United States

RECRUITING

First Physicians Group - Urology Robotic and Minimally Invasive Surgery

Sarasota, Florida, 34239, United States

RECRUITING

First Physicians Group-Sarasota

Sarasota, Florida, 34239, United States

RECRUITING

FPG Gastrointestinal Oncology at Medical Arts

Sarasota, Florida, 34239, United States

RECRUITING

Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States

RECRUITING

Sarasota Memorial Health Care Center at University Parkway

Sarasota, Florida, 34243, United States

RECRUITING

Saint Anthony's Hospital Cancer Care Center

St. Petersburg, Florida, 33705, United States

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607, United States

RECRUITING

Florida Cancer Specialists - Venice Pinebrook

Venice, Florida, 34275, United States

RECRUITING

Florida Cancer Specialists - Venice Island

Venice, Florida, 34285, United States

RECRUITING

Grady Health System

Atlanta, Georgia, 30303, United States

RECRUITING

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

RECRUITING

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

RECRUITING

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States

RECRUITING

Northside Hospital

Atlanta, Georgia, 30342, United States

RECRUITING

Augusta University Medical Center

Augusta, Georgia, 30912, United States

RECRUITING

Emory Decatur Hospital

Decatur, Georgia, 30033, United States

RECRUITING

CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States

ACTIVE NOT RECRUITING

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States

RECRUITING

Island Urology

Honolulu, Hawaii, 96813, United States

SUSPENDED

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States

RECRUITING

Queen's Medical Center

Honolulu, Hawaii, 96813, United States

RECRUITING

Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States

RECRUITING

University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States

RECRUITING

Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States

SUSPENDED

Kuakini Medical Center

Honolulu, Hawaii, 96817, United States

RECRUITING

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States

RECRUITING

The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States

RECRUITING

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States

RECRUITING

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States

RECRUITING

Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

RECRUITING

Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States

RECRUITING

Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States

RECRUITING

Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States

RECRUITING

The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States

RECRUITING

The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States

RECRUITING

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

RECRUITING

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

RECRUITING

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

RECRUITING

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States

RECRUITING

Rush-Copley Medical Center

Aurora, Illinois, 60504, United States

SUSPENDED

Advocate Outpatient Center - Aurora

Aurora, Illinois, 60506, United States

RECRUITING

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States

RECRUITING

Carle BroMenn Outpatient Center

Bloomington, Illinois, 61704, United States

RECRUITING

Northwestern University

Chicago, Illinois, 60611, United States

RECRUITING

Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States

RECRUITING

University of Illinois

Chicago, Illinois, 60612, United States

SUSPENDED

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States

RECRUITING

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States

RECRUITING

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014, United States

RECRUITING

Carle at The Riverfront

Danville, Illinois, 61832, United States

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States

RECRUITING

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515, United States

RECRUITING

Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States

RECRUITING

Advocate Sherman Hospital

Elgin, Illinois, 60123, United States

RECRUITING

Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126, United States

RECRUITING

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

RECRUITING

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States

RECRUITING

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States

RECRUITING

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026, United States

ACTIVE NOT RECRUITING

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030, United States

ACTIVE NOT RECRUITING

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States

RECRUITING

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States

RECRUITING

Sudarshan K Sharma MD Limited-Gynecologic Oncology

Hinsdale, Illinois, 60521, United States

ACTIVE NOT RECRUITING

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States

RECRUITING

AMG Libertyville - Oncology

Libertyville, Illinois, 60048, United States

RECRUITING

Condell Memorial Hospital

Libertyville, Illinois, 60048, United States

RECRUITING

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States

RECRUITING

Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States

RECRUITING

UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States

RECRUITING

Carle BroMenn Medical Center

Normal, Illinois, 61761, United States

RECRUITING

Carle Cancer Institute Normal

Normal, Illinois, 61761, United States

RECRUITING

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699, United States

RECRUITING

Rush MD Anderson Cancer Center at Rush Oak Park

Oak Park, Illinois, 60304, United States

RECRUITING

University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States

RECRUITING

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States

RECRUITING

Edward Hospital/Cancer Center?Plainfield

Plainfield, Illinois, 60585, United States

RECRUITING

Springfield Clinic

Springfield, Illinois, 62702, United States

RECRUITING

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

RECRUITING

Carle Cancer Center

Urbana, Illinois, 61801, United States

RECRUITING

The Carle Foundation Hospital

Urbana, Illinois, 61801, United States

RECRUITING

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States

RECRUITING

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States

SUSPENDED

Midwestern Regional Medical Center

Zion, Illinois, 60099, United States

ACTIVE NOT RECRUITING

IU Health North Hospital

Carmel, Indiana, 46032, United States

RECRUITING

UChicago Medicine Northwest Indiana

Crown Point, Indiana, 46307, United States

RECRUITING

Goshen Center for Cancer Care

Goshen, Indiana, 46526, United States

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

RECRUITING

Community Cancer Center North

Indianapolis, Indiana, 46256, United States

ACTIVE NOT RECRUITING

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, Indiana, 46260, United States

RECRUITING

Baptist Health Floyd

New Albany, Indiana, 47150, United States

SUSPENDED

Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503, United States

SUSPENDED

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503, United States

RECRUITING

Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ

Council Bluffs, Iowa, 51503, United States

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States

RECRUITING

University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States

RECRUITING

University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States

RECRUITING

University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States

RECRUITING

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States

RECRUITING

Baptist Health Corbin

Corbin, Kentucky, 40701, United States

RECRUITING

Saint Elizabeth Healthcare Edgewood

Edgewood, Kentucky, 41017, United States

ACTIVE NOT RECRUITING

Baptist Health Hardin

Elizabethtown, Kentucky, 42701, United States

SUSPENDED

Baptist Health Lexington

Lexington, Kentucky, 40503, United States

RECRUITING

Norton Hospital Pavilion and Medical Campus

Louisville, Kentucky, 40202, United States

RECRUITING

Baptist Health Louisville

Louisville, Kentucky, 40207, United States

RECRUITING

Norton Suburban Hospital and Medical Campus

Louisville, Kentucky, 40207, United States

RECRUITING

Norton Audubon Hospital and Medical Campus

Louisville, Kentucky, 40217, United States

RECRUITING

Norton Brownsboro Hospital and Medical Campus

Louisville, Kentucky, 40241, United States

RECRUITING

Baptist Health Madisonville/Merle Mahr Cancer Center

Madisonville, Kentucky, 42431, United States

ACTIVE NOT RECRUITING

Baptist Health Paducah

Paducah, Kentucky, 42003, United States

RECRUITING

Baptist Health Richmond

Richmond, Kentucky, 40475, United States

SUSPENDED

West Jefferson Medical Center

Marrero, Louisiana, 70072, United States

RECRUITING

Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States

RECRUITING

University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States

RECRUITING

Willis-Knighton Medical and Cancer Center

Shreveport, Louisiana, 71103, United States

RECRUITING

MaineHealth Maine Medical Center - Portland

Portland, Maine, 04102, United States

RECRUITING

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States

RECRUITING

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

ACTIVE NOT RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

ACTIVE NOT RECRUITING

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States

RECRUITING

Christiana Care - Union Hospital

Elkton, Maryland, 21921, United States

RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States

ACTIVE NOT RECRUITING

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

RECRUITING

Baystate Medical Center

Springfield, Massachusetts, 01199, United States

RECRUITING

Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States

RECRUITING

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

RECRUITING

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

RECRUITING

Corewell Health Farmington Hills Hospital

Farmington Hills, Michigan, 48336, United States

RECRUITING

McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

RECRUITING

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

RECRUITING

Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States

RECRUITING

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

RECRUITING

Oakland Colon Rectal Associates

Royal Oak, Michigan, 48067, United States

RECRUITING

Cancer Care Associates PC

Royal Oak, Michigan, 48073, United States

RECRUITING

Comprehensive Medical Center PLLC

Royal Oak, Michigan, 48073, United States

RECRUITING

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States

RECRUITING

Hematology Oncology Consultants PC-Royal Oak

Royal Oak, Michigan, 48073, United States

RECRUITING

Oakland Medical Group

Royal Oak, Michigan, 48073, United States

RECRUITING

Premier Hematology Oncology Care

Sterling Heights, Michigan, 48312, United States

RECRUITING

Michigan Institute of Urology-Town Center

Troy, Michigan, 48084, United States

RECRUITING

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States

RECRUITING

Hematology Oncology Consultants PC-Troy

Troy, Michigan, 48098, United States

RECRUITING

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States

RECRUITING

Cambridge Medical Center

Cambridge, Minnesota, 55008, United States

RECRUITING

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

RECRUITING

Fairview Southdale Hospital

Edina, Minnesota, 55435, United States

RECRUITING

Unity Hospital

Fridley, Minnesota, 55432, United States

ACTIVE NOT RECRUITING

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States

RECRUITING

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

RECRUITING

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States

RECRUITING

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

RECRUITING

Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States

RECRUITING

Health Partners Inc

Minneapolis, Minnesota, 55454, United States

RECRUITING

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States

RECRUITING

Monticello Cancer Center

Monticello, Minnesota, 55362, United States

RECRUITING

New Ulm Medical Center

New Ulm, Minnesota, 56073, United States

RECRUITING

Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States

RECRUITING

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

RECRUITING

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

RECRUITING

Regions Hospital

Saint Paul, Minnesota, 55101, United States

RECRUITING

United Hospital

Saint Paul, Minnesota, 55102, United States

RECRUITING

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States

RECRUITING

Lakeview Hospital

Stillwater, Minnesota, 55082, United States

RECRUITING

Ridgeview Medical Center

Waconia, Minnesota, 55387, United States

RECRUITING

Rice Memorial Hospital

Willmar, Minnesota, 56201, United States

RECRUITING

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States

RECRUITING

Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States

RECRUITING

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States

RECRUITING

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

RECRUITING

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

SUSPENDED

Washington University School of Medicine

St Louis, Missouri, 63110, United States

SUSPENDED

Mercy Hospital South

St Louis, Missouri, 63128, United States

SUSPENDED

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

SUSPENDED

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

SUSPENDED

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

RECRUITING

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

RECRUITING

Community Medical Center

Missoula, Montana, 59804, United States

SUSPENDED

Fred and Pamela Buffett Cancer Center - Kearney

Kearney, Nebraska, 68845, United States

RECRUITING

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114, United States

RECRUITING

Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States

RECRUITING

Oncology Associates PC

Omaha, Nebraska, 68114, United States

SUSPENDED

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118, United States

RECRUITING

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States

SUSPENDED

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

RECRUITING

Women's Cancer Center of Nevada

Las Vegas, Nevada, 89106, United States

RECRUITING

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States

RECRUITING

Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States

RECRUITING

Jersey City Medical Center

Jersey City, New Jersey, 07302, United States

RECRUITING

Saint Barnabas Medical Center

Livingston, New Jersey, 07039, United States

RECRUITING

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States

RECRUITING

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States

RECRUITING

Morristown Medical Center

Morristown, New Jersey, 07960, United States

RECRUITING

Virtua Memorial

Mount Holly, New Jersey, 08060, United States

RECRUITING

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

RECRUITING

Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States

RECRUITING

Capital Health Medical Center-Hopewell

Pennington, New Jersey, 08534, United States

RECRUITING

Penn Medicine Princeton Health

Plainsboro, New Jersey, 08536, United States

ACTIVE NOT RECRUITING

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080, United States

RECRUITING

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States

RECRUITING

Overlook Hospital

Summit, New Jersey, 07902, United States

RECRUITING

Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States

RECRUITING

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

RECRUITING

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110, United States

ACTIVE NOT RECRUITING

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124, United States

RECRUITING

Women's Cancer Care Associates LLC

Albany, New York, 12208, United States

RECRUITING

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706, United States

RECRUITING

South Shore University Hospital

Bay Shore, New York, 11706, United States

RECRUITING

Island Gynecologic Oncology

Brightwaters, New York, 11718, United States

RECRUITING

Memorial Sloan Kettering Commack

Commack, New York, 11725, United States

RECRUITING

Northwell Health Physician Partners at Flushing

Flushing, New York, 11354, United States

RECRUITING

Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

RECRUITING

Huntington Hospital

Huntington, New York, 11743, United States

RECRUITING

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States

RECRUITING

North Shore University Hospital

Manhasset, New York, 11030, United States

RECRUITING

NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States

RECRUITING

Northern Westchester Hospital

Mount Kisco, New York, 10549, United States

RECRUITING

Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States

RECRUITING

Northwell Health Physician Partners

New Hyde Park, New York, 11042, United States

RECRUITING

Mount Sinai Chelsea

New York, New York, 10011, United States

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

RECRUITING

Mount Sinai West

New York, New York, 10019, United States

RECRUITING

Mount Sinai Hospital

New York, New York, 10029, United States

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States

ACTIVE NOT RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

RECRUITING

NYP/Weill Cornell Medical Center

New York, New York, 10065, United States

RECRUITING

Lenox Hill Hospital

New York, New York, 10075, United States

RECRUITING

Vassar Brothers Medical Center

Poughkeepsie, New York, 12601, United States

SUSPENDED

Northwell Physician Partners at Rego Park

Rego Park, New York, 11374, United States

RECRUITING

Queens Cancer Center

Rego Park, New York, 11374, United States

RECRUITING

Highland Hospital

Rochester, New York, 14620, United States

RECRUITING

University of Rochester

Rochester, New York, 14642, United States

RECRUITING

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591, United States

RECRUITING

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

RECRUITING

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

RECRUITING

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States

RECRUITING

Wilmot Cancer Institute at Webster

Webster, New York, 14580, United States

RECRUITING

Mission Hospital

Asheville, North Carolina, 28801, United States

RECRUITING

Hope Women's Cancer Centers-Asheville

Asheville, North Carolina, 28816, United States

RECRUITING

Duke Cancer Center Cary

Cary, North Carolina, 27518, United States

RECRUITING

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

RECRUITING

Duke University Medical Center

Durham, North Carolina, 27710, United States

RECRUITING

Duke Women's Cancer Care Raleigh

Raleigh, North Carolina, 27607, United States

RECRUITING

Duke Cancer Center Raleigh

Raleigh, North Carolina, 27609, United States

RECRUITING

Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401, United States

RECRUITING

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

RECRUITING

Cleveland Clinic Akron General

Akron, Ohio, 44307, United States

SUSPENDED

Aultman Alliance Community Hospital

Alliance, Ohio, 44601, United States

RECRUITING

OhioHealth O'Bleness Hospital

Athens, Ohio, 45701, United States

RECRUITING

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States

RECRUITING

Aultman Health Foundation

Canton, Ohio, 44710, United States

RECRUITING

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

RECRUITING

Geauga Hospital

Chardon, Ohio, 44024, United States

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States

RECRUITING

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States

RECRUITING

Bethesda North Hospital

Cincinnati, Ohio, 45242, United States

RECRUITING

TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States

RECRUITING

TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States

RECRUITING

Case Western Reserve University

Cleveland, Ohio, 44106, United States

RECRUITING

MetroHealth Medical Center

Cleveland, Ohio, 44109, United States

SUSPENDED

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States

RECRUITING

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States

RECRUITING

Riverside Methodist Hospital

Columbus, Ohio, 43214, United States

RECRUITING

Grant Medical Center

Columbus, Ohio, 43215, United States

RECRUITING

Doctors Hospital

Columbus, Ohio, 43228, United States

RECRUITING

Miami Valley Hospital

Dayton, Ohio, 45409, United States

RECRUITING

Miami Valley Hospital North

Dayton, Ohio, 45415, United States

RECRUITING

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States

RECRUITING

Grady Memorial Hospital

Delaware, Ohio, 43015, United States

RECRUITING

Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016, United States

RECRUITING

Dublin Methodist Hospital

Dublin, Ohio, 43016, United States

RECRUITING

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States

RECRUITING

Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States

RECRUITING

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States

RECRUITING

OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States

RECRUITING

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States

RECRUITING

University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States

RECRUITING

OhioHealth Pickerington Methodist Hospital

Pickerington, Ohio, 43147, United States

RECRUITING

ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States

RECRUITING

Upper Valley Medical Center

Troy, Ohio, 45373, United States

RECRUITING

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States

RECRUITING

OhioHealth Westerville Medical Campus/Westerville Cancer Center

Westerville, Ohio, 43082, United States

RECRUITING

UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, 44145, United States

RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

RECRUITING

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

RECRUITING

Saint Charles Health System

Bend, Oregon, 97701, United States

RECRUITING

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States

RECRUITING

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States

SUSPENDED

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

RECRUITING

Providence Hood River Memorial Hospital

Hood River, Oregon, 97031, United States

RECRUITING

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

RECRUITING

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

RECRUITING

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States

RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Oregon Health and Science University

Portland, Oregon, 97239, United States

RECRUITING

Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States

RECRUITING

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062, United States

RECRUITING

Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States

NOT YET RECRUITING

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States

RECRUITING

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

RECRUITING

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025, United States

RECRUITING

Lancaster General Ann B Barshinger Cancer Institute

Lancaster, Pennsylvania, 17601, United States

RECRUITING

Lancaster General Hospital

Lancaster, Pennsylvania, 17602, United States

RECRUITING

Forbes Hospital

Monroeville, Pennsylvania, 15146, United States

RECRUITING

Allegheny Valley Hospital

Natrona Heights, Pennsylvania, 15065, United States

RECRUITING

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States

RECRUITING

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

RECRUITING

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States

RECRUITING

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States

RECRUITING

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

Chester County Hospital

West Chester, Pennsylvania, 19380, United States

RECRUITING

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090, United States

RECRUITING

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States

RECRUITING

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States

RECRUITING

Women and Infants Hospital

Providence, Rhode Island, 02905, United States

RECRUITING

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States

RECRUITING

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

RECRUITING

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States

RECRUITING

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States

RECRUITING

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

RECRUITING

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

RECRUITING

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

RECRUITING

SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States

RECRUITING

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

RECRUITING

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

RECRUITING

Vanderbilt-Ingram Cancer Center at Franklin

Franklin, Tennessee, 37067, United States

RECRUITING

Vanderbilt-Ingram Cancer Center Cool Springs

Franklin, Tennessee, 37067, United States

RECRUITING

Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States

RECRUITING

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States

RECRUITING

Parkland Memorial Hospital

Dallas, Texas, 75235, United States

WITHDRAWN

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States

ACTIVE NOT RECRUITING

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234, United States

SUSPENDED

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States

RECRUITING

Ben Taub General Hospital

Houston, Texas, 77030, United States

RECRUITING

Memorial Hermann Texas Medical Center

Houston, Texas, 77030, United States

RECRUITING

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

ACTIVE NOT RECRUITING

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106, United States

RECRUITING

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

RECRUITING

University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States

RECRUITING

Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States

RECRUITING

Inova Fair Oaks Hospital

Fairfax, Virginia, 22033, United States

RECRUITING

Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States

RECRUITING

Henrico Doctor's Hospital

Richmond, Virginia, 23229, United States

RECRUITING

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States

RECRUITING

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States

RECRUITING

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24033, United States

RECRUITING

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States

RECRUITING

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

RECRUITING

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States

RECRUITING

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

RECRUITING

Providence Regional Cancer Partnership

Everett, Washington, 98201, United States

RECRUITING

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

RECRUITING

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

RECRUITING

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States

RECRUITING

PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States

RECRUITING

Skagit Regional Health Cancer Care Center

Mount Vernon, Washington, 98274, United States

RECRUITING

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States

RECRUITING

Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States

RECRUITING

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States

RECRUITING

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

RECRUITING

University of Washington Medical Center - Northwest

Seattle, Washington, 98133, United States

RECRUITING

Women's Cancer Center of Seattle

Seattle, Washington, 98133, United States

SUSPENDED

University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States

RECRUITING

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States

RECRUITING

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States

SUSPENDED

Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States

RECRUITING

Cancer Care Northwest-Valley

Spokane, Washington, 99216, United States

RECRUITING

Cancer Care Northwest-North Spokane

Spokane, Washington, 99218, United States

RECRUITING

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States

RECRUITING

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States

RECRUITING

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States

SUSPENDED

United Hospital Center

Bridgeport, West Virginia, 26330, United States

RECRUITING

West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States

RECRUITING

WVUH-Berkely Medical Center

Martinsburg, West Virginia, 25401, United States

RECRUITING

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

RECRUITING

Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States

RECRUITING

Princeton Community Hospital

Princeton, West Virginia, 24740, United States

RECRUITING

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States

RECRUITING

Aurora Saint Luke's South Shore

Cudahy, Wisconsin, 53110, United States

RECRUITING

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States

RECRUITING

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

RECRUITING

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States

RECRUITING

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

RECRUITING

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States

RECRUITING

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

RECRUITING

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States

RECRUITING

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States

RECRUITING

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States

RECRUITING

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States

SUSPENDED

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States

RECRUITING

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

SUSPENDED

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States

RECRUITING

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States

RECRUITING

Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States

RECRUITING

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States

SUSPENDED

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States

SUSPENDED

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States

RECRUITING

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States

RECRUITING

BCCA-Vancouver Cancer Centre

Vancouver, British Columbia, V5Z 4E6, Canada

RECRUITING

CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada

RECRUITING

Keimyung University-Dongsan Medical Center

Dalseo-gu, Daegu, 42601, South Korea

RECRUITING

Samsung Changwon Hospital

Seoul, Gyeongsangnam-do, 51353, South Korea

RECRUITING

Seoul National University Bundang Hospital

Seongnam, Kyeonggi-do, 463-707, South Korea

RECRUITING

Chung-Ang University Gwangmyeong Hospital

Gwangmyeong, 14347, South Korea

RECRUITING

Asan Medical Center

Seoul, 05505, South Korea

SUSPENDED

Gangnam Severance Hospital

Seoul, 06273, South Korea

RECRUITING

Ewha Woman's University Mokdong Hospital

Seoul, 07985, South Korea

RECRUITING

Yonsei University Health System-Severance Hospital

Seoul, 120-752, South Korea

RECRUITING

Related Publications (1)

  • Pennington KP, Pugh SL, Huh W, Walker JL, Jewell E, Havrilesky LJ, Carter J, Muller CY, Drapkin R, Lankes HA, Castellano T, Zamorano AS, Blank SV, Kachnic LA. Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy. Obstet Gynecol. 2025 Jan 1;145(1):21-30. doi: 10.1097/AOG.0000000000005781. Epub 2024 Nov 7.

MeSH Terms

Conditions

Ovarian Neoplasms

Interventions

OvariectomySpecimen HandlingMagnetic Resonance SpectroscopyHigh-Energy Shock Waves

Condition Hierarchy (Ancestors)

Endocrine Gland NeoplasmsNeoplasms by SiteNeoplasmsOvarian DiseasesAdnexal DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital Neoplasms, FemaleUrogenital NeoplasmsGenital DiseasesEndocrine System DiseasesGonadal Disorders

Intervention Hierarchy (Ancestors)

CastrationEndocrine Surgical ProceduresSurgical Procedures, OperativeUrogenital Surgical ProceduresGynecologic Surgical ProceduresClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative TechniquesSpectrum AnalysisChemistry Techniques, AnalyticalUltrasonic WavesSoundRadiation, NonionizingRadiationPhysical Phenomena

Study Officials

  • Kathryn P Pennington

    NRG Oncology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: This is a non-randomized prospective trial to determine if bilateral salpingectomy (BLS) is non-inferior to bilateral salpingo-oophorectomy (BSO) in terms ovarian, primary peritoneal, and fallopian tube cancer risk among gBRCA1m carriers between 35 and 50 years old. Individuals choose the treatment they want to receive in collaboration with their physician(s).
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 14, 2020

First Posted

January 31, 2020

Study Start

September 1, 2020

Primary Completion (Estimated)

June 30, 2047

Study Completion (Estimated)

June 30, 2047

Last Updated

March 27, 2026

Record last verified: 2026-03

Locations