Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

NCT04228510 | Unknown

• 1 other identifier: 2DSE
• Study Type: observational
• Target: 204
• Locations: 0 countries
• Sites: N/A

Brief Summary

ST-segment elevation myocardial infarction (STEMI) is a major cause of morbidity and mortality worldwide. In spite of decrease in acute and long-term mortality following STEMI in parallel with more use of reperfusion therapy, such as primary percutaneous coronary intervention (PPCI), modern antithrombotic therapy, and secondary prevention, mortality remains considerable. Reduced EF is a well-known predictor of increased short and long term major adverse cardiovascular events MACE :( heart failure, stroke and death)

Conditions

Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• The Incidence of major adverse cardiovascular events

  the rate of Acute coronary syndrome, Heart failure, Stroke and all-cause mortality

  1 year

Study Arms (1)

Study group

ST elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention who will be followed up in Assiut University hospital.

Procedure: 2D speckle tracking echocardiography

Interventions

2D speckle tracking echocardiography PROCEDURE

Global and segmental strain and strain rate in longitudinal and circumferential directions will be detected after PPCI; before discharge. The LV circumferential strains and strain rates will be determined from the short-axis views at the basal, middle, and apical levels, and longitudinal strains and strain rates will be determined from the apical 2-, 3-, and 4-chamber views of the LV. Segmental longitudinal strains equal to -15% or closer to 0 will be considered abnormal (injured segments). The average segmental longitudinal strain and strain rate of the abnormal segments is defined as the injury longitudinal strain (InjLS) and injury longitudinal systolic strain rate (InjLSRs).

Study group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ST elevation myocardial infarction patients after primary percutaneous coronary intervention who will be followed up for a one year in Assiut University hospital.

You may qualify if:

• ST elevation myocardial infarction patients after primary percutaneous coronary intervention

You may not qualify if:

• Previous myocardial infarction.
• Sever or haemodynamically significant (associated with chamber dilation) valvular heart diseases.
• Previous heart failure.
• Previous cerebrovascular strokes.
• Atrial fibrillation.
• Severe comorbidities as severe renal impairment, hepatic or respiratory failure.
• Bad equality views which affects accurate speckle tracking imaging.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Hatem Helmy, MD

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Aly Tohamy, MD

CONTACT

01006258877; Ali.tohamy@gmail.com

Ayman Khairy, MD

CONTACT

01094438055; Aymankhairy11@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 12, 2020
• First Posted: January 14, 2020
• Study Start: March 1, 2020
• Primary Completion: September 1, 2021
• Study Completion: December 1, 2021
• Last Updated: January 14, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share