The Effect of Degree of Rice-polishing on Glycaemic Response

NCT04228341 | Completed

• 1 other identifier: 2018/01079
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Conditions

Diabetes Mellitus; Obesity

Outcome Measures

Primary Outcomes (1)

• Glucose

  Whole capillary blood glucose will be measure using Hemocue analyser

  Up to 180 minutes

Secondary Outcomes (1)

• Insulin

  Up to 180 minutes

Study Arms (8)

Glucose Reference 1

OTHER

Glucose solution 1

Other: Glucose Reference 1

Glucose Reference 2

OTHER

Glucose solution 2

Other: Glucose Reference 2

Glucose Reference 3

OTHER

Glucose solution 3

Other: Glucose Reference 3

Brown Rice

EXPERIMENTAL

Cooked brown rice

Other: Brown Rice

3 % polished rice

EXPERIMENTAL

Cooked 3 % polished rice

Other: 3 % polished rice

6 % polished rice

EXPERIMENTAL

Cooked 6 % polished rice

Other: 6 % polished rice

9 % polished rice

EXPERIMENTAL

9 % polished rice

Other: 9 % polished rice

20 % Polished rice

EXPERIMENTAL

Cooked 20 % Polished rice (White Rice)

Other: 20 % Polished rice

Interventions

Glucose Reference 1 OTHER

50 g of glucose dissolved in 250 ml of water (First glucose control visit)

Glucose Reference 1

Glucose Reference 2 OTHER

50 g of glucose dissolved in 250 ml of water (Second glucose control visit)

Glucose Reference 2

Glucose Reference 3 OTHER

50 g of glucose dissolved in 250 ml of water (Third glucose control visit)

Glucose Reference 3

Brown Rice OTHER

Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2

Brown Rice

3 % polished rice OTHER

3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

3 % polished rice

6 % polished rice OTHER

6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

6 % polished rice

9 % polished rice OTHER

9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2

9 % polished rice

20 % Polished rice OTHER

White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

20 % Polished rice

Eligibility Criteria

• Age: 21 Years - 60 Years
• Gender Eligibility Details: Male only
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Chinese ethnicity
• Age ≥21 and ≤ 60 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure =\<140/90 mmHg
• Fasting blood glucose \<6.0 mmol/L
• In general good health

You may not qualify if:

• Current smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have intolerances or allergies to any foods
• Currently partake in sports at the competitive and/or endurance levels
• Intentionally restrict food intake

Sponsors & Collaborators

• Singapore Institute of Food and Biotechnology Innovation: lead

Study Sites (1)

Clinical Nutrition Research Centre

Singapore, 117599, Singapore

Location

MeSH Terms

Conditions

Diabetes Mellitus; Obesity

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized crossover design

Study Record Dates

• First Submitted: January 11, 2020
• First Posted: January 14, 2020
• Study Start: February 13, 2019
• Primary Completion: July 26, 2019
• Study Completion: June 18, 2020
• Last Updated: August 20, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)