Natural Antioxidant Intake After Exercise Can Oxidative Stress in the Third Trimester of Pragnancy

NCT04226183 | Completed

• 1 other identifier: qwery123
• Study Type: interventional
• Target: 24
• Locations: 0 countries
• Sites: N/A

Brief Summary

Pregnancy is a condition that increased requirements of energy and oxygen, and if this condition is not maximally that can lead oxidative stress and produce free radicals which is affect in the pregnancy process. Malondialdehyde (MDA) level in pregnant women is higher than non-pregnant women. Exercise is one way to neutralize the free radical. The aim of this study was analyzed effect of treatment natural antioxidants after exercise which was pregnancy workout to MDA level in the third trimester of pregnancy. This study was a true experimental study. There were 24 prenatal pregnant women and separated to 3 groups, which were 8 prenatal pregnant women without pregnancy workout as a control group, 8 prenatal pregnant women with pregnancy workout but without natural antioxidant consume as a positive control group, and 8 prenatal pregnant women with natural antioxidant consume after pregnancy workout as a treatment group. The antioxidant compounds given in this study were guava juice that contains vitamin C. MDA levels was analyzed by spectrophotometric. Comparison between groups was done by one way ANOVA test.

Conditions

Stress Oxidative

Keywords

Antioxidants; Malondialdehyde level; the third trimester of pregnancy; exercise; anti oxidant; stress oxidative

Outcome Measures

Primary Outcomes (1)

• MDA level

  Malondialdehyde (MDA) levels is stress oxidative marker. MDA level messured with spectrophotometric assay. at Bio Sains Riset Laboratory, Palembang. Firstly, Mix 0.5ml blank + 0.5 ml standard and 0.5 ml serum using vortex mixer. Centrifuge for 10 minutes, with a speed of 2000 rpm, and Pipette 1 ml each filtrate and after that put it in boiling water bath for 30 minutes, then chill and read the absorbance with a spectrophotometer with a wavelength of 550 nm.

  7 days.

Study Arms (3)

control group

NO INTERVENTION

pregnant women without pregnancy workout and consume guava juice

positive control group

EXPERIMENTAL

prenatal pregnant women with pregnancy workout but not consume guava juice

Other: pregnancy workout

treatment group

EXPERIMENTAL

prenatal pregnant women with pregnancy workout and consume guava juice

Other: pregnancy workout

Interventions

pregnancy workout OTHER

Procedure of pregnancy workout has been legalized by the Ministry of Health of Indonesia act 2014 No.97. 100 ml fresh guava juice without sugar

Also known as: fresh Guava juice

positive control group; treatment group

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Approve as a subject of review and sign in an informed consent
• Approve to take 3 ml of whole blood.
• Ages 20-30 years
• Hemoglobin levels higher than 11 gr%
• Third trimester of pregnancy
• Healthy condition during reseach

You may not qualify if:

• Anemia
• Pathologies condition during pregnant
• Allergic
• Disability

Sponsors & Collaborators

• Indonesia University: lead
• Indonesia-MoH: collaborator

Related Publications (2)

• Nazari A, Dirandeh E, Ansari-Pirsaraei Z, Deldar H. Antioxidant levels, copper and zinc concentrations were associated with postpartum luteal activity, pregnancy loss and pregnancy status in Holstein dairy cows. Theriogenology. 2019 Jul 15;133:97-103. doi: 10.1016/j.theriogenology.2019.04.034. Epub 2019 Apr 30.

  PMID: 31078069 RESULT

• Patil SB, Kodliwadmath MV, Kodliwadmath SM. Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension. Indian J Clin Biochem. 2008 Jan;23(1):45-8. doi: 10.1007/s12291-008-0011-9. Epub 2008 Mar 6.

  PMID: 23105719 RESULT

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Ocktariyana Ocktariyana

  Ministry of health, Health Polytechnic, Palembang

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, INVESTIGATOR
• Masking Details: care provider is a midwifery as a intructure of excercise and measure of each pregnant participans condition. investigator is controling all reseach procedure.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: There were 24 prenatal pregnant women and separated to 3 groups, which were 8 prenatal pregnant women without exercise as a control group, 8 prenatal pregnant women with exercise as a positive control group and 8 prenatal pregnant women with exercise and consume natural antioxidants after exercise as a treatment group. The antioxidant compounds given in this study were guava juice that contains vitamin C.

Study Record Dates

• First Submitted: January 9, 2020
• First Posted: January 13, 2020
• Study Start: February 3, 2016
• Primary Completion: August 26, 2016
• Study Completion: October 17, 2016
• Last Updated: January 18, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share