Resistance Plus Aerobic Training Using Different Weekly Frequencies And Hypertension

NCT04218903 | Completed

• 1 other identifier: 19816719900005327
• Study Type: interventional
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

Combined training is a cornerstone intervention to improve functionality and to reduce blood pressure in older adults with hypertension. Acute blood pressure lowering after exercise seems to predict the extent of blood pressure reduction after chronic training interventions. Based on that, the same weekly amount of exercise performed more frequently could be more beneficial to blood pressure management. The aim of the present study is to evaluate the effects of a combined exercise program performed four versus two times per week on 24-h ambulatory blood pressure and other cardiovascular risk factors in older individuals with hypertension.

Conditions

Hypertension; Cardiovascular Risk Factor; Cardiovascular Diseases

Keywords

Aging; Ambulatory Blood Pressure Monitoring; Concurrent Training; Dose-response

Outcome Measures

Primary Outcomes (1)

• Ambulatory Blood Pressure

  24h ambulatory blood pressure measured through automatic oscillometric device

  Change from baseline 24-hour systolic blood pressure at 12 weeks

Secondary Outcomes (6)

• Systolic blood pressure

  Change from baseline office blood pressure at 12 weeks

• Diastolic blood pressure

  Change from baseline office blood pressure at 12 weeks

• Cardiorespiratory fitness

  Change from baseline VO2peak at 12 weeks

• Upper limbs muscle strength

  Change from baseline handgrip test at 12 weeks

• Lower limbs muscle strength

  Change from baseline sitting-rising test at 12 weeks

Study Arms (2)

Combined Training 4 times per week (CT4)

EXPERIMENTAL

The CT4 group will perform four sessions per week of combined exercise program. This intervention will last 12 weeks.

Behavioral: Combined training performed four times per week (CT4)

Combined Training 2 times per week (CT2)

ACTIVE COMPARATOR

The CT2 group will perform two sessions per week of combined exercise program. This intervention will last 12 weeks.

Behavioral: Combined training performed two times per week (CT2)

Interventions

Combined training performed four times per week (CT4) BEHAVIORAL

CT4 will perform four combined training sessions per week throughout 12 weeks. Each session will be composed 10-15 minutes of resistance exercise (1-4 sets of 10-15 repetitions, using an intensity corresponding to 50-70%1RM in 3 exercises) followed by 20-25 minutes of aerobic exercise (walking or running at an intensity corresponding to 60-70% of VO2peak).

Combined Training 4 times per week (CT4)

Combined training performed two times per week (CT2) BEHAVIORAL

CT2 will perform two combined training sessions per week throughout 12 weeks. Each session will be composed 20-30 minutes of resistance exercise (1-4 sets of 10-15 repetitions, using an intensity corresponding to 50-70%1RM in 6 exercises) followed by 40-50 minutes of aerobic exercise (walking or running at an intensity corresponding to 60-70% of VO2peak).

Combined Training 2 times per week (CT2)

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Office blood pressure between 130-179 and 80-110 mmHg for systolic and diastolic blood pressure, respectively or taking at least one antihypertensive medication
• Not engaged in structured exercise programs (3 or more times per week) in the last 3 months before the study

You may not qualify if:

• Physical and muscular injuries that limit to accomplishment of the different training proposed in the study
• Underlying cardiovascular disease in the last 24 months such as acute myocardial infarction, angina, stroke or heart failure
• Health conditions that limit physical exercise perform, such as lung disease, valvar heart disease, renal failure
• Diseases that reduce life expectancy
• BMI \> 39.9 kg/m²
• Diabetic proliferative retinopathy

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead
• Federal University of Rio Grande do Sul: collaborator

Study Sites (1)

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035903, Brazil

Location

MeSH Terms

Conditions

Hypertension; Cardiovascular Diseases

Interventions

CD5L protein, human

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

• Rodrigo Ferrari, PhD

  Federal University of Rio Grande do Sul

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 3, 2020
• First Posted: January 6, 2020
• Study Start: March 1, 2022
• Primary Completion: December 31, 2024
• Study Completion: March 31, 2025
• Last Updated: April 24, 2025

Record last verified: 2025-04

Locations

BR (1)