Central Arterial Hemodynamics and Resistance Training

NCT04546308 | Completed

• 1 other identifier: 201903034RIND
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Resistance exercise training is one of the popular exercise modes that has been drawn the public's attention. However, existing evidence showed high-intensity resistance exercise training-induced negative adaptation on vascular function and blood pressure responses. Upper-body resistance exercise training is more likely to induced arterial stiffening, which has been shown to be gender-dependent. It is still unknown whether age also plays a role. We like to test the hypothesis that high-intensity upper body resistance exercise may lead to a higher increase of arterial stiffness, central blood pressure, and hemodynamic parameters in younger adults than older adults. We also hypothesize high intensity resistance training could contribute to greater central hemodynamic responses and muscle stiffness than the control; the change of muscle stiffness correlates with the change of hemodynamic parameters. Collectively, study 1 in this project is aimed to recruit 40 apparently healthy young (20-35yrs) and middle-aged to older adults (50-75yrs) into this study followed by upper-body or lower-body high-intensity exercise (80% 1 repetition maximum, 10 reps, 4 sets) by a randomized order. Blood draw, central blood pressure, hemodynamics will be performed and obtained at pre-, immediately-post, 20min, 40mins, and 60 mins post-exercise. Study 2 is aimed to investigate the effects of 8-week whole-body resistance exercise training followed by a 4-week detraining on above-measured variables in order to determine the long-term effects on resistance training. We will employee state-of-art ultrafast ultrasound to obtain muscle stiffness and carotid local pulse wave velocity. Endothelin-1 and catecholamines will also be measured to discover its underlying mechanisms on such stiffening effects induced by high-intensity resistance exercise.

Conditions

Hypertension; Cardiovascular Risk Factor

Keywords

Exercise; Ultrafast ultrasound

Outcome Measures

Primary Outcomes (3)

• Central blood pressure

  Carotid blood pressure obtained by using tonometer

  Pre, 8th and 12th week

• Muscle shear wave velocity

  Shear wave velocity measured by using ultrafast ultrasound

  Pre, 8th and 12th week

• Arterial pulse wave velocity

  Pulse wave velocity measured by using a commercialized vascular monitor.

  Pre, 8th and 12th week

Secondary Outcomes (1)

• Vascular related biomarkers

  Pre, 8th and 12th week

Study Arms (2)

Exercise training

EXPERIMENTAL

The participants will undergo 8 weeks of whole-body resistance exercise training followed by a 4-week detraining. The central hemodynamic and muscle stiffness variables will be measured pre, post-training, and post-detraining.

Other: Resistance exercise training

Sedentary control

NO INTERVENTION

The participants will undergo 12 weeks of intervention without exercise training. The central hemodynamic and muscle stiffness variables will be measured pre, 8th, and 12th week.

Interventions

Resistance exercise training OTHER

Eight weeks whole-body resistance exercise training (80%1 repetition maximal, 3 sessions per week) followed by a 4-week detraining intervention

Exercise training

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy middle-aged to older adults

You may not qualify if:

• (1)BMI≧27, (2) Smoking habits for more than six months in the past, (3) Hypertension (blood pressure\>140/90 mmHg), (4) Personal diabetes history (fasting blood sugar \>126 mg /dL), heart disease, or other cardiovascular diseases, (5) bone damage, (6) regular use of supplements or vitamins

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University

Taipei, 106, Taiwan

Location

MeSH Terms

Conditions

Hypertension; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 6, 2020
• First Posted: September 14, 2020
• Study Start: December 21, 2019
• Primary Completion: July 31, 2022
• Study Completion: July 31, 2022
• Last Updated: December 23, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)