Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer
1 other identifier
observational
120
1 country
1
Brief Summary
Biomaterial-based cell culture models have been gaining increasing attention as potential therapeutic strategies. The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients. Through controllable cell-material interaction, this project has the intention to develop an alternative tool for both early diagnosis and accurate prognosis in cancer therapeutics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 17, 2019
CompletedStudy Start
First participant enrolled
January 5, 2020
CompletedFirst Posted
Study publicly available on registry
January 6, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 17, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2022
CompletedJanuary 14, 2020
December 1, 2019
11 months
December 17, 2019
January 12, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The correlation between the cell detachment ratio and the overall survival
The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be correlated with the overall survival in lung cancer patients, hence serve as a prognostic factor for therapeutic strategies. The patient's information required for meta-analysis will be retrieved from medical records, and the log-term follow-up will be conducted.
5-year follow-up after tumor resection
Secondary Outcomes (1)
The analyses of the detached cells by specific markers
About one week
Eligibility Criteria
At the discretion of the professional attending physician, the lung cancer patients who need to undergo resection of lung lesions.
You may qualify if:
- Lung cancer patient between 20-70 years old who need surgery for the resection of lung lesions.
- Willing to sign the consent form under the informed consent.
You may not qualify if:
- Vulnerable subjects included minors, prisoners, aborigines, pregnant women, people with mental disorders, students, and subordinates, etc.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Taiwan University Hospital
Taipei, Taiwan
Study Officials
- PRINCIPAL INVESTIGATOR
Tai-Horng Young, Ph.D.
Department of Biomedical Engineering, National Taiwan University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 17, 2019
First Posted
January 6, 2020
Study Start
January 5, 2020
Primary Completion
November 17, 2020
Study Completion
December 1, 2022
Last Updated
January 14, 2020
Record last verified: 2019-12