Survival Significance of Molecular Pathology and Genetic Variation in Brain Gliomas

NCT04216537 | Unknown

• 1 other identifier: GiomaMG-1
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to collect clinical, radiological, pathological, molecular and genetic data including detailed clinical parameters, MR and histopathology images, molecular pathology and genetic data. This study seeks to find the prognostic and clinical significance based on molecular and genetic biomarkers/subgroups of gliomas.

Conditions

Glioma; Molecular Sequence Variation; Genetic Change

Keywords

Survival; Subgroup

Outcome Measures

Primary Outcomes (1)

• Overall Survival (OS)

  The length of time from enrollment until the time of death (OS, overall survival)

  From enrollment to death of patients. Estimated about 5 years.

Interventions

Glioma groups based on molecular pathology or genetic variation DIAGNOSTIC_TEST

Patients with newly diagnosed glioma that receive tumor resection

Eligibility Criteria

• Age: 1 Year - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Subjects are all received tumor resection in the First Affiliated Hospital of Zhengzhou University.

You may qualify if:

• Patients must have radiologically and histologically confirmed diagnosis of primary glioma
• Life expectancy of greater than 3 months
• Must receive tumor resection
• Must have sufficient fresh frozen tissues for NGS
• Signed informed consent

You may not qualify if:

• No gliomas
• No sufficient amount of tumor tissues for detection of molecular pathology
• Patients who are pregnant or breast feeding
• Patients who are suffered from severe systematic malfunctions
• Do not have sufficient fresh frozen tissues for NGS

Sponsors & Collaborators

• The First Affiliated Hospital of Zhengzhou University: lead

Study Sites (1)

Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

All participants have signed the informed consent. Fresh frozen tissues of participants are collected immediately after tumor resection and preserved in liquid nitrogen. Whole exome sequencing, RNA sequencing and proteomics are planed to be conducted.

MeSH Terms

Conditions

Glioma

Interventions

Genetic Variation

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Intervention Hierarchy (Ancestors)

Genetic Phenomena

Central Study Contacts

Zhenyu Zhang, Dr.

CONTACT

+86 17839973727; fcczhangzy1@zzu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: December 31, 2019
• First Posted: January 2, 2020
• Study Start: January 1, 2018
• Primary Completion: January 1, 2025
• Study Completion: June 1, 2025
• Last Updated: February 8, 2021

Record last verified: 2021-02

Locations

CN (1)