Sintilimab Combined With Bevacizumab for Brain Metastases From Non-small Cell Lung Cancer

NCT04213170 | Unknown Phase 2 DMC

• 1 other identifier: B2019-050-01
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective phase II clinical study to assess the efficacy of Sintilimab combined with Bevacizumab for driving gene-negative, asymptomatic brain metastases from non-small cell lung cancer by intracranial ORR(iORR),also iPFS,ORR and PFS.The safety and tolerability is evaluated as well.

Conditions

Brain Metastases; Non Small Cell Lung Cancer; Sintilimab; Bevacizumab

Outcome Measures

Primary Outcomes (1)

• iORR

  intracranial objective response rate

  3.5 years

Secondary Outcomes (3)

• iPFS

  3.5 yesrs

• ORR

  3.5 years

• PFS

  3.5 years

Study Arms (1)

Sintilimab and Bevacizumab

EXPERIMENTAL

Sintilimab 200mg d1 and Bevacizumab 15mg/kg d1 every 21 days

Drug: sintilimab

Interventions

sintilimab DRUG

Sintilimab 200mg d1 and Bevacizumab 15mg/kg d1 q21d

Also known as: bevacizumab

Sintilimab and Bevacizumab

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with NSCLC confirmed by histology or cytology;
• Patients with asymptomatic brain metastasis or brain metastasis whose symptoms of intracranial hypertension have been alleviated after dehydration treatment should keep the clinical stable state for at least 2 weeks.For patients requiring hormone dehydration therapy, hormone therapy should be discontinued 3 days before the first dose of the study drug.
• Appraisable disease, the diameter of at least one measurable lesion in the brain must be 5mm;
• The detection results of tumor tissue biomarkers should meet the following conditions simultaneously: EGFR has no sensitive mutation;ALK rearrangement negative;for never treated patients, they also needed to meet PD-L1 \>50% or TMB\>12Mut/Mb (second-generation sequencing).
• Adult patients (≥ 18 years and ≤75 years). ECOG Performance Status 0 or 1 Life expectancy of at least 12 weeks.,Haemoglobin ³ 10.0 g/dl, Absolute neutrophil count (ANC) ³1.5 x 109/L, platelets ³ 100 x 109/L. Total bilirubin £ 1.5 x upper limit of normal (ULN). ALT and AST \< 2.5 x ULN in the absence of liver metastases, or \< 5 x ULN in case of liver metastases. Creatinine clearance ³ 60ml/min (calculated according to Cockcroft-gault formula).
• Ability to follow study and follow-up procedures;
• Prior to the implementation of any trial-related procedures, a written informed consent shall be signed.

You may not qualify if:

• Mixed non-small cell and small cell carcinoma;
• Brain metastasis with hemorrhage;
• Currently participating in interventional clinical research and treatment, or receiving other research drugs or using research instruments within 4 weeks before the first dose;
• Previously received the following therapies: anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs targeting another stimulation or synergistic inhibition of T cell receptors (e.g., CTLA-4, CD137);
• Received solid organ or blood system transplantation;
• Received \>30GY pulmonary radiotherapy 6 months before the first dose;
• Active autoimmune diseases requiring systemic treatment (such as the use of disease-relieving drugs, corticosteroids or immunosuppressants) occurred within 2 years before the first dose.Alternative therapies (such as thyroxine, insulin, or physiological corticosteroids for adrenal or pituitary insufficiency) are not considered systemic;
• Received systemic glucocorticoid therapy or any other form of immunosuppressive therapy within 7 days before the first dose of the study or diagnosed as immunodeficiency;a physiological dose of glucocorticoid (10 mg/ day of prednisone or equivalent) is permitted;
• History of non-infectious pneumonia requiring glucocorticoid therapy or current interstitial pulmonary disease was found within 1 year before the first dose;
• History of human immunodeficiency virus (HIV) infection (i.e. HIV 1/2 antibody positive)
• Untreated active hepatitis;
• History of hemoptysis within 3 months prior to selection, that is, at least 1/2 teaspoon of blood was coughed up;
• Imaging showed signs of tumor invasion into the great vessels.The investigator or radiologist must rule out patients whose tumors have completely approached, wrapped, or invaded the intravascular space of the great vessels
• Serious uncontrolled coagulation disorder or thrombi-embolic complications within 6 months prior to study start or history of serious bleeding complications.
• Major surgical procedures within 4 weeks prior to study entry.

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

Sun Yat-sen University of Cancer Center

Guangzhou, Guangdong, China

RECRUITING

MeSH Terms

Conditions

Brain Neoplasms; Carcinoma, Non-Small-Cell Lung

Interventions

sintilimab; Bevacizumab

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal; Antibodies; Immunoglobulins; Immunoproteins; Blood Proteins; Proteins; Amino Acids, Peptides, and Proteins; Serum Globulins; Globulins

Study Officials

• Likun Chen, doctor

  Sun Yat-sen University

  STUDY DIRECTOR

Central Study Contacts

Likun Chen, doctor

CONTACT

13798019964; chenlk@sysucc.org.cn

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: medical doctor

Study Record Dates

• First Submitted: December 25, 2019
• First Posted: December 30, 2019
• Study Start: April 29, 2019
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: December 30, 2019

Record last verified: 2019-05

Locations

CN (1)