Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography

NCT04187170 | Completed DMC

• 1 other identifier: 19-092
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will benefit from a high-intensity pure resistance training program over a 6-month period. The volunteers, aged between 18 and 40 years old and male, will be recruited and evaluated at the University Hospital center of Caen Normandy. Cardiac remodeling in response to physical exercise will be analyzed by trans-thoracic echocardiography repeated during the follow-up. The physical impact of the training program will be assessed by a treadmill exercise test predicting maximal oxygen consumption (VO2max) before and after completing the training, and an isokinetic muscular test repeated every 3 months. Participants rest/activity cycles will be monitor before and after 3 months of training. The aim of the study is to demonstrate the existence of a physiologic RV remodeling in response to pure high-load resistance chronic exercise. The results will help to improve the understanding of the physiological RV response expected in strength athletes.

Conditions

Cardiac Remodeling, Ventricular; Right Ventricular Hypertrophy

Keywords

Right ventricle; cardiac physiology; strength training; echocardiography

Outcome Measures

Primary Outcomes (1)

• Assessment of right ventricular volumes change over 6 months of sustained high-strength physical training.

  Analysis of variation in echocardiographic measurements of RV volumes before and after training

  Before the training starts and up to 6 months of follow-up

Study Arms (1)

Healthy sedentary subjects exposed to the training program

EXPERIMENTAL

Other: Strength physical training

Interventions

Strength physical training OTHER

progressive high-load strength training over 6 months, consisting in repeated physical exercises to increase the muscular mass and force by altering concentric and eccentric muscle contractions against high resistance.

Healthy sedentary subjects exposed to the training program

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 40 years
• Male gender
• Agree to participate in the study (signature of consent).
• Affiliated to an insurance scheme or beneficiary

You may not qualify if:

• Female gender
• Inability to express consent
• Moderate physical activity over than 150 minutes or intensive physical activity over than 75 minutes per week on a regular basis for more than 6 consecutive months, according to the World Health Organisation criteria.
• Participation in competitive sports of ≥ II and / or B according to Mitchell's classification in the last 3 years.
• Ischemic and non-ischemic heart diseases
• Family history of unexplained sudden death
• Personal or family history of elastic tissue disease (Marfan syndrome and related)
• Chronic diseases incompatible with physical exercise at high intensity
• Personal history of chemotherapy and / or radiotherapy
• ≥ 1 cardiovascular risk factors
• use of doping substances
• Body mass index \> 30 kg/m²

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

University Hospital of Caen

Caen, Normandy, 14000, France

Location

Related Publications (2)

• Pamart N, Drigny J, Azambourg H, Remilly M, Lahjaily K, Rocamora A, Tournoux F, Saloux E, Reboursiere E, Gauthier A, Hodzic A. Association between muscle strength gains and biventricular cardiac remodeling in response to high-intensity resistance training in healthy untrained males: a longitudinal study. BMC Sports Sci Med Rehabil. 2025 May 7;17(1):116. doi: 10.1186/s13102-025-01165-8.

  PMID: 40336139 DERIVED

• Pamart N, Drigny J, Azambourg H, Remilly M, Macquart M, Lefevre A, Lahjaily K, Parienti JJ, Rocamora A, Guermont H, Desvergee A, Ollitrault P, Tournoux F, Saloux E, Normand H, Reboursiere E, Gauthier A, Hodzic A. Effects of a 20-Week High-Intensity Strength Training Program on Muscle Strength Gain and Cardiac Adaptation in Untrained Men: Preliminary Results of a Prospective Longitudinal Study. JMIR Form Res. 2023 Oct 24;7:e47876. doi: 10.2196/47876.

  PMID: 37874630 DERIVED

Related Links

• Abstract Journées Européennes de la Société Française de Cardiologie 2024
• Effects of a 20-Week High-Intensity Strength Training Program on Muscle Strength Gain and Cardiac Adaptation in Untrained Men: Preliminary Results of a Prospective Longitudinal Study

MeSH Terms

Conditions

Ventricular Remodeling; Hypertrophy, Right Ventricular

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Cardiomegaly; Heart Diseases; Cardiovascular Diseases; Hypertrophy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: November 17, 2019
• First Posted: December 5, 2019
• Study Start: January 13, 2022
• Primary Completion: June 20, 2023
• Study Completion: August 20, 2023
• Last Updated: February 13, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)