Intracardiac Flow Remodeling in Athletes

NCT03076788 | Completed

• 1 other identifier: 16-022.
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. This study is observational, we do not interfere with athlete's training.

Conditions

Cardiac Remodeling, Ventricular

Keywords

echocardiography; intraventricular pressure gradients; cardiac remodeling; athletes

Outcome Measures

Primary Outcomes (1)

• Evaluation of ventricular response to exercise training by echocardiography.

  1. 2D- morphological and functional parameters of both left and right ventricles: * end-diastolic and end-systolic dimensions (cm) * left ventricular mass (g) * ventricular end-diastolic and end-systolic areas (cm²) * ventricular ejection fraction (%) * atrial volumes (ml) * diastolic indices by pulsed wave Doppler and tissue Doppler (cm/s) * myocardial deformation by speckle tracking (%) 2. 3D- morphological and functional parameters of both left and right ventricles: * ventricular full volumes (ml) * ejection fraction (%) 3. Intracardiac flow measurements by color Doppler M-mode: estimation of intra ventricular pressure gradients between the base and the apex (mmHg).

  Day 1

Secondary Outcomes (2)

• Evaluation of ventricular response to exercise training by electrocardiogram

  Day 1

• Sport and medical history questionnaire

  Day 1

Study Arms (2)

Athletes

Professional and amateur athletes examined during the medical follow-up at the medical sport centre of Caen University Hospital. The medical examination consists in a clinical exam, an electrocardiogram and an echocardiography.

Other: electrocardiogram and echocardiography

Sedentary controls

Sedentary patients assessed in the cardiology unit with a normal heart function. The medical examination consists in a clinical exam, an electrocardiogram and an echocardiography.

Other: electrocardiogram and echocardiography

Interventions

electrocardiogram and echocardiography OTHER

We retrieved all electrocardiograms and echocardiography made during the clinical examination of each athlete and each sedentary control. * Standard 12 lead ECG * Trans-thoracic echocardiography examination of cardiac function, morphology and intracardiac flow.

Athletes; Sedentary controls

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Athletes

You may qualify if:

• Age \> 18yrs old
• Ability to give written consent for participating in the study

You may not qualify if:

• Age \< 18yrs old
• Cardiac diseases, arterial hypertension, cardiac devices, diabetes, renal, liver or pulmonary failure

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

CHU de CAEN

Caen, Normandy, 14000, France

Location

MeSH Terms

Conditions

Ventricular Remodeling

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: February 16, 2017
• First Posted: March 10, 2017
• Study Start: January 1, 2017
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: February 13, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)