Low Resistance Venous Blood Flow Restriction Training (LR-VBFRT) on Biceps Brachii Muscle Performance

NCT04181671 | Completed DMC

• 1 other identifier: RiphahIU 00563
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Resistance training has been widely recognized as an effective stimulus for increasing skeletal muscle size and strength. This study intends to compare the effects of high resistance training without blood flow restriction and the low resistance training with blood flow restriction training on bicep muscle performance.

Conditions

Muscle Weakness Condition

Keywords

Exercise Training

Outcome Measures

Primary Outcomes (10)

• Muscle strength

  Handheld dynamometer will be used for measuring muscle strength of bicep muscle of all participants by single examiner

  Baseline

• Muscle strength

  Handheld dynamometer will be used for measuring muscle strength of bicep muscle of all participants by single examiner

  Post 6 weeks

• 1 Repetition maximum

  1RM will be assess using Epley's formula of 1RM , RM= w(1+r/30) where "w" is the sub maximal weight and "r" is repetition then percentages of 1RM will be used for training purposes 80% of 1 RM for control group and 30% of 1RM for experimental group.

  Baseline

• 1 Repetition maximum

  1RM will be assess using Epley's formula of 1RM , RM= w(1+r/30) where "w" is the sub maximal weight and "r" is repetition then percentages of 1RM will be used for training purposes 80% of 1 RM for control group and 30% of 1RM for experimental group.

  Post 6 weeks

• Bicep Muscle power

  Muscle power will be assesses of all the participants using power formula(Power= W/t= FS/t) for that force (F) will be assessed through dynamometer in newton covered distance (S) will be taken as covered range of motion and will be asses through goniometer (elbow flexion in supinated position). Time (t) will be calculated using stop watch

  Baseline

• Bicep Muscle power

  Muscle power will be assesses of all the participants using power formula(Power= W/t= FS/t) for that force (F) will be assessed through dynamometer in newton covered distance (S) will be taken as covered range of motion and will be asses through goniometer (elbow flexion in supinated position). Time (t) will be calculated using stop watch

  Post 6 weeks

• Bicep muscle endurance testing

  Bicep muscle endurance will be calculated prior to the intervention by asking participants to lift light -moderate weight and perform bicep curls in supinated position the total number of repetition they will perform doing complete eccentric and concentric movement of the muscle will be taken as the endurance of the bicep muscle

  Baseline

• Bicep muscle endurance testing

  Bicep muscle endurance will be calculated prior to the intervention by asking participants to lift light -moderate weight and perform bicep curls in supinated position the total number of repetition they will perform doing complete eccentric and concentric movement of the muscle will be taken as the endurance of the bicep muscle

  Post 6 weeks

• Arm circumference

  arm circumference will be measured in centimeters at the midpoint between the acromion process and the center of the elbow(by measuring tape)

  Baseline

• Arm circumference

  arm circumference will be measured in centimeters at the midpoint between the acromion process and the center of the elbow(by measuring tape)

  Post 6 weeks

Study Arms (2)

Low Resistance Training Group

EXPERIMENTAL

The experimental group will receive low resistance blood flow restriction training with 30% of 1 RM.

Other: Low Resistance training with venous blood flow restriction

High Resistance Training Group

ACTIVE COMPARATOR

Participants of this group will receive High resistance training (80% of 1 RM) without blood flow restriction.

Other: High Resistance training

Interventions

Low Resistance training with venous blood flow restriction OTHER

Total 20 males will participate in this group after warmup , Blood flow restriction will be provided through sphygmomanometer optimum pressure will be measured through following formula occlusion pressure (mmHg) = 0.514 (SBP) + 0.339 (DBP) + 1.461 (Arm circumference) + 17.236 then 30% of 1RM will be used for training . The standard protocol will be used which is four sets (1st set-30 repetitions, 2nd set-15 repetitions, 3rd set-15 repetitions, and 4th set-15 repetitions) with 30-60 s of interval between sets. ( the cuff must be deflated between sets of exercise) for 8 weeks (24) sessions on non-consecutive days. participants will be re-assessed for all baseline variables after 8 weeks of training biceps curls will be used for training. Heart Rate and oxygen saturation will be measured during the session through Pulse oximeter

Low Resistance Training Group

High Resistance training OTHER

Total 20 males will participate in this group after warm up. 80% of 1RM will be used for training, 3 sets of 8 repetitions will be used with 30-60 s of interval between sets. for 8 weeks (24) sessions on non-consecutive days.No blood flow restriction will be applied to this group Participants will be re-assessed for all baseline variables after 8 weeks of training. Bicep curls will be used for training.

High Resistance Training Group

Eligibility Criteria

• Age: 20 Years - 28 Years
• Gender Eligibility Details: Only male participants are recruited in the study.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males
• Age: 20-28 year
• Body mass index: 18.5-24.9

You may not qualify if:

• Vascular Disease
• Upper Limb Pathology Requiring Surgical Intervention
• Upper Limb Musculoskeletal Issues
• Blood Pressure \>140/90
• Coronary Artery Disease
• Venous Thromboembolism
• Congenital Cardiac Diseases
• Syncope, Arrhythmias, Smokers
• Alcohol Use
• Supplements Intake
• whey Protein Intake

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

RCRAHS Potohar campus

Rawalpindi, Punjab Province, 44000, Pakistan

Location

Related Publications (5)

• Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002 Nov;88(1-2):50-60. doi: 10.1007/s00421-002-0681-6. Epub 2002 Aug 15.

  PMID: 12436270 BACKGROUND

• Lixandrao ME, Ugrinowitsch C, Laurentino G, Libardi CA, Aihara AY, Cardoso FN, Tricoli V, Roschel H. Effects of exercise intensity and occlusion pressure after 12 weeks of resistance training with blood-flow restriction. Eur J Appl Physiol. 2015 Dec;115(12):2471-80. doi: 10.1007/s00421-015-3253-2. Epub 2015 Sep 1.

  PMID: 26323350 BACKGROUND

• Mattar MA, Gualano B, Perandini LA, Shinjo SK, Lima FR, Sa-Pinto AL, Roschel H. Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis. Arthritis Res Ther. 2014 Oct 25;16(5):473. doi: 10.1186/s13075-014-0473-5.

  PMID: 25344395 BACKGROUND

• Wilson JM, Lowery RP, Joy JM, Loenneke JP, Naimo MA. Practical blood flow restriction training increases acute determinants of hypertrophy without increasing indices of muscle damage. J Strength Cond Res. 2013 Nov;27(11):3068-75. doi: 10.1519/JSC.0b013e31828a1ffa.

  PMID: 23446173 BACKGROUND

• Loenneke JP, Allen KM, Mouser JG, Thiebaud RS, Kim D, Abe T, Bemben MG. Blood flow restriction in the upper and lower limbs is predicted by limb circumference and systolic blood pressure. Eur J Appl Physiol. 2015 Feb;115(2):397-405. doi: 10.1007/s00421-014-3030-7. Epub 2014 Oct 22.

  PMID: 25338316 BACKGROUND

Study Officials

• Huma Riaz, PHD*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: This study will be single blinded randomized control trail, participants will be unaware of treatment groups, they will be randomly allocated through sealed envelope method.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Both experimental and control groups will be treated at the same time following their respective protocols

Study Record Dates

• First Submitted: November 26, 2019
• First Posted: November 29, 2019
• Study Start: November 4, 2019
• Primary Completion: January 1, 2020
• Study Completion: January 10, 2020
• Last Updated: January 22, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)