Trials Sponsors Conditions Drugs Pricing

Conditions

Mitochondrial Biogenesis

Keywords

MitochondriaExercise trainingVO2Aerobic exerciseCitrate SynthaseBlood flow restriction

Outcome Measures

Primary Outcomes (1)

Citrate Synthase
Fold change in citrate synthase maximal activity
3 days prior to start of exercise training and 3 days after completing exercise training

Secondary Outcomes (11)

Transcription factor A, mitochondrial (TFAM)
3 days before training to 3 days after training
Nuclear respiratory factor, 1 (NRF1)
3 days before training to 3 days after training
Maximal oxygen consumption (VO2peak)
3 days before training to 3 days after training
Heart rate (HR)
Every 5 minutes during each of the 7, 30-minute exercise sessions
Revolutions per minute (RPM)
Every 5 minutes during each of the 7, 30-minute exercise sessions
+6 more secondary outcomes

Study Arms (2)

BFR

EXPERIMENTAL

Other: BFR Exercise Training

CTL

EXPERIMENTAL

Other: CTL Exercise Training

Interventions

BFR Exercise TrainingOther

Participants will complete exercise training on a recumbent bike placed on a 45 degree incline (BFR).

BFR

CTL Exercise TrainingOther

Participants will complete exercise training on a recumbent bike placed on flat ground (CTL).

CTL

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 30 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

You may qualify if:

hours of physical activity per week
No previous cycling training

Sponsors & Collaborators

Brendon Gurd, PhD
Otherlead

Study Sites (1)

Queen's University

Kingston, Ontario, K7L3N6, Canada

Related Publications (1)

Preobrazenski N, Mladen SPS, Causer E, Menezes E, Islam H, Drouin PJ, Tschakovsky ME, Gurd BJ. Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial. Transl Exerc Biomed. 2025 Mar 26;2(1):9-20. doi: 10.1515/teb-2025-0002. eCollection 2025 May.
PMID: 40224168DERIVED

Study Officials

Brendon J Gurd, PhD
Queen's University
PRINCIPAL INVESTIGATOR

Enrollment

19 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: DOUBLE
Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details: Allocation concealment, assessor blinding
Purpose: BASIC SCIENCE
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Associate Professor

Study Record Dates

First Submitted

April 2, 2019

First Posted

November 5, 2019

Study Start

May 6, 2019

Actual (reported)

Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (11)

Study Arms (2)

BFR

CTL

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (11)

Study Arms (2)

BFR

CTL

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations