Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults
1 other identifier
interventional
19
1 country
1
Brief Summary
This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase. Participants will be randomized to either a blood flow restricted or non-blood flow restricted exercise training group. Both groups will complete seven, 30-minute exercise sessions over a 14-day period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 2, 2019
CompletedStudy Start
First participant enrolled
May 6, 2019
CompletedFirst Posted
Study publicly available on registry
November 5, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 13, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 13, 2019
CompletedDecember 26, 2023
December 1, 2023
7 months
April 2, 2019
December 19, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Citrate Synthase
Fold change in citrate synthase maximal activity
3 days prior to start of exercise training and 3 days after completing exercise training
Secondary Outcomes (11)
Transcription factor A, mitochondrial (TFAM)
3 days before training to 3 days after training
Nuclear respiratory factor, 1 (NRF1)
3 days before training to 3 days after training
Maximal oxygen consumption (VO2peak)
3 days before training to 3 days after training
Heart rate (HR)
Every 5 minutes during each of the 7, 30-minute exercise sessions
Revolutions per minute (RPM)
Every 5 minutes during each of the 7, 30-minute exercise sessions
- +6 more secondary outcomes
Study Arms (2)
BFR
EXPERIMENTALCTL
EXPERIMENTALInterventions
Participants will complete exercise training on a recumbent bike placed on a 45 degree incline (BFR).
Participants will complete exercise training on a recumbent bike placed on flat ground (CTL).
Eligibility Criteria
You may qualify if:
- hours of physical activity per week
- No previous cycling training
- No concurrent involvement in another training program
- Body mass index \< 30 kg/m2
You may not qualify if:
- Presence of cardiovascular disease
- Presence of metabolic disease
- Taking regular oral medication
- Current smoker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Queen's University
Kingston, Ontario, K7L3N6, Canada
Related Publications (1)
Preobrazenski N, Mladen SPS, Causer E, Menezes E, Islam H, Drouin PJ, Tschakovsky ME, Gurd BJ. Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial. Transl Exerc Biomed. 2025 Mar 26;2(1):9-20. doi: 10.1515/teb-2025-0002. eCollection 2025 May.
PMID: 40224168DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Brendon J Gurd, PhD
Queen's University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Allocation concealment, assessor blinding
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
April 2, 2019
First Posted
November 5, 2019
Study Start
May 6, 2019
Primary Completion
December 13, 2019
Study Completion
December 13, 2019
Last Updated
December 26, 2023
Record last verified: 2023-12