NCT04137211

Brief Summary

The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy brain functions, namely cerebral blood flow. It is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day at the office.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
13

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 13, 2019

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

October 15, 2019

Completed
8 days until next milestone

First Posted

Study publicly available on registry

October 23, 2019

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 13, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 13, 2020

Completed
Last Updated

December 15, 2022

Status Verified

December 1, 2022

Enrollment Period

10 months

First QC Date

October 15, 2019

Last Update Submit

December 12, 2022

Conditions

Healthy Adults

Outcome Measures

Primary Outcomes (1)

  • Changes in cerebral blood flow

    Oxygenated and deoxygenated hemoglobin concentration changes measured with functional near-infrared spectroscopy

    before to after 3 hour intervention

Secondary Outcomes (7)

  • Augmentation index

    before to after 3 hour intervention

  • Blood glucose levels

    during the 3 hour intervention

  • Cortisol

    before to after 3 hour intervention

  • Mood

    before to after 3 hour intervention

  • Sleepiness

    before to after 3 hour intervention

  • +2 more secondary outcomes

Study Arms (3)

Prolonged sitting with social break

EXPERIMENTAL
Behavioral: Prolonged sitting with social break

Prolonged sitting with walk break

EXPERIMENTAL
Behavioral: Prolonged sitting with walk break

Prolonged sitting with simple resistance activities

EXPERIMENTAL
Behavioral: Prolonged sitting with simple resistance activities

Interventions

Prolonged sitting with social breakBEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a short social break. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Prolonged sitting with social break
Prolonged sitting with walk breakBEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform a brisk walk for about three minutes on a treadmill at a predetermined speed and grade based on the fitness test performed during the familiarization session. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Prolonged sitting with walk break
Prolonged sitting with simple resistance activitiesBEHAVIORAL

Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform simple resistance activities following a video for about three minutes. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Prolonged sitting with simple resistance activities

Eligibility Criteria

Age40 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • \- Has a BMI under 35kg/m2

You may not qualify if:

  • Has diabetes, epilepsy, or circulatory conditions
  • Has experienced heart failure, stroke, or myocardial infarction
  • Takes treatment for high blood pressure, sleep disorders, depression, or psychosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Swedish School of Sport and Health Sciences (GIH)

Stockholm, 114 86, Sweden

Location

Related Publications (1)

  • Heiland EG, Tarassova O, Fernstrom M, English C, Ekblom O, Ekblom MM. Frequent, Short Physical Activity Breaks Reduce Prefrontal Cortex Activation but Preserve Working Memory in Middle-Aged Adults: ABBaH Study. Front Hum Neurosci. 2021 Sep 16;15:719509. doi: 10.3389/fnhum.2021.719509. eCollection 2021.

    PMID: 34602995DERIVED

Study Officials

  • Maria Ekblom, PhD

    The Swedish School of Sport and Health Sciences (GIH)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 15, 2019

First Posted

October 23, 2019

Study Start

May 13, 2019

Primary Completion

March 13, 2020

Study Completion

March 13, 2020

Last Updated

December 15, 2022

Record last verified: 2022-12

Locations

SE(1)