Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
1 other identifier
observational
50
1 country
1
Brief Summary
The investigators will observe increased or decreased CBV in patients with thermal injury compared with the CBV in healthy controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 10, 2019
CompletedFirst Posted
Study publicly available on registry
October 14, 2019
CompletedStudy Start
First participant enrolled
October 25, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 15, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 20, 2019
CompletedNovember 14, 2019
October 1, 2019
2 months
October 10, 2019
November 13, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
cerebral blood volume
magnetic resonance imaging(MRI) was used to evaluate cerebral blood volume(CBV) of pain network
1 week
Secondary Outcomes (1)
visual analogue scale
1 week
Study Arms (2)
Burn patients
The subjects complaine of severe neuropathic pain that is rated at least 5 on the visual analogue scale (VAS), despite treatments with gabapentin medication and other physical modalities.
Healthy controls
age and sex matched healthy controls
Interventions
magnetic resonance imaging(MRI) will be used to evaluate cerebral blood volume(CBV) of pain network
Eligibility Criteria
The patients complained of severe neuropatic pain rated at least 5 on the 10-point numerical rating scale (NRS), despite being treated with drugs and physical therapy for more than 1 week after being admitted to the Department of Rehabilitation Medicine.
You may qualify if:
- Burn patients
- severe neuropatic pain rated at least 5 on the 10-point numerical rating scale (NRS).
You may not qualify if:
- cardiac arrest history
- history of neurologic disease or brain surgery
- unstable heart disease or presence of a cardiac pacemaker
- psychiatric disorder
- diabetes mellitus
- abnormal renal function
- contraindication for MRI
- pregnancy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hangang Sacred Heart Hospital
Seoul, Yeong-deungpo-Dong, 150-719, South Korea
Related Publications (2)
Park CH, Seo CH, Jung MH, Joo SY, Jang S, Lee HY, Ohn SH. Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury. Neuroradiology. 2017 Sep;59(9):915-921. doi: 10.1007/s00234-017-1876-1. Epub 2017 Jul 8.
PMID: 28689261BACKGROUNDSeo CH, Park CH, Jung MH, Jang S, Joo SY, Kang Y, Ohn SH. Preliminary Investigation of Pain-Related Changes in Cerebral Blood Volume in Patients With Phantom Limb Pain. Arch Phys Med Rehabil. 2017 Nov;98(11):2206-2212. doi: 10.1016/j.apmr.2017.03.010. Epub 2017 Apr 6.
PMID: 28392326BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 10, 2019
First Posted
October 14, 2019
Study Start
October 25, 2019
Primary Completion
December 15, 2019
Study Completion
December 20, 2019
Last Updated
November 14, 2019
Record last verified: 2019-10
Data Sharing
- IPD Sharing
- Will not share