Prospective Multicenter Study for Early Evaluation of Acute Chest Pain
PEACP
1 other identifier
observational
10,000
1 country
9
Brief Summary
In this study, clinical database and blood sample bank of acute chest pain (ACP) will be established at chest pain center of multi-center hospital. To explore new biomarkers and screen clinical indicators with effective risk stratification and prognostic evaluation for ACP through proteomics technology and statistics methods. Risk stratification and short-term and long-term prognostic evaluation models for high-risk ACP will be established using large data analysis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2019
Typical duration for all trials
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 6, 2019
CompletedFirst Posted
Study publicly available on registry
October 10, 2019
CompletedStudy Start
First participant enrolled
November 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 31, 2022
CompletedNovember 29, 2019
November 1, 2019
2 years
October 6, 2019
November 27, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (7)
Rate of participants with all-cause death
Patients die of all causes during hospitalization or follow-up
One year
Rate of participants with cardiovascular death
Patients die of cardiac and cerebrovascular diseases during hospitalization or follow-up
One year
Rate of participants with major adverse cardiac events (MACEs)
MACEs include cardiac death, stroke, and recurrent myocardial infarction.
One year
Rate of participants with acute myocardial infarction
Chest pain patients are diagnosed as acute myocardial infarction based on fourth edition of guidelines for myocardial infarction
Twenty-four hours
Rate of participants with acute pulmonary embolism
Chest pain patients are diagnosed as acute pulmonary embolism based on CT of pulmonary angiography.
Twenty-four hours
Rate of participants with acute aortic dissection
Chest pain patients are diagnosed as acute aortic dissection based on CT of aortic angiography.
Twenty-four hours
Rate of participants with acute coronary syndrome
Chest pain patients are diagnosed as acute coronary syndrome based on European Society of Cardiology (ESC) guidelines.
Twenty-four hours
Secondary Outcomes (12)
Rate of participants with ischemia or necrosis of lower limbs
Two weeks
Rate of participants with acute heart failure
Two weeks
Rate of participants with revascularization
Two weeks
Rate of participants with consciousness disorder
Two weeks
Rate of participants with cardiogenic shock
Two weeks
- +7 more secondary outcomes
Other Outcomes (2)
Length of stay
Two weeks
Rate of re-admitted participants
Six months
Study Arms (1)
Acute chest pain
The population in this study are characterized by acute chest pain as the first symptom for consultation within 24 hours.
Interventions
Acute chest pain patients, suspected acute coronary syndrome, are diagnosed by coronary angiography.
Acute chest pain patients, suspected acute aortic dissection, are diagnosed by gold standard of CTA.
Acute chest pain patients, suspected acute pulmonary embolism, are diagnosed by gold standard of CTA.
All patients with acute chest pain will subject to ECG examination within 10 minutes of admission, which can quickly screen ST-segment elevation myocardial infarction.
Dynamic changes of cardiac troponin I and/or T will be used in the diagnosis of acute myocardial infarction
Eligibility Criteria
The population in this study is characterized by acute chest pain as the first symptom for consultation. These are mainly Han and Tibetan patients from southwest China. The study population included first-visit and referral patients.
You may qualify if:
- Patient aged 18-90 years old;
- The time from onset of symptoms to emergency room is less than 24 hours.
You may not qualify if:
- Patients complicate with end-stage neoplastic diseases;
- Pregnant women;
- Patients re-visit during the selection period;
- Patients refuse to participate in this study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (9)
Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou, 563000, China
Chengdu Second People's Hospital
Chengdu, Sichuan, 610021, China
Chengdu Shangjin Nanfu Hospital
Chengdu, Sichuan, 610041, China
Sichuan Integrative Medicine Hospital
Chengdu, Sichuan, 610041, China
West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
People's Hospital of Xindu District
Chengdu, Sichuan, 610500, China
Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, 646099, China
Panzhihua Central Hospital
Panzhihua, Sichuan, 617000, China
Zigong Fourth People's Hospital
Zigong, Sichuan, 643000, China
Related Publications (1)
Li F, Li D, Yu J, Jia Y, Wen J, Li W, Tong Y, Wu J, Wan Z, Cao Y, Zhang Q, Zeng R. Association Between Plasma Ceramides and One-Year Mortality in Patients with Acute Coronary Syndrome: Insight from the PEACP Study. Clin Interv Aging. 2023 Apr 6;18:571-584. doi: 10.2147/CIA.S402253. eCollection 2023.
PMID: 37050937DERIVED
Biospecimen
Whole blood and plasma
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dongze Li, MBBS
Emergency Department, West China Hospital, Sichuan University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer, Clinical Research
Study Record Dates
First Submitted
October 6, 2019
First Posted
October 10, 2019
Study Start
November 1, 2019
Primary Completion
October 31, 2021
Study Completion
October 31, 2022
Last Updated
November 29, 2019
Record last verified: 2019-11
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF
- Time Frame
- Six months after completion of the test
- Access Criteria
- IPD will be public accessable via Electronic Data Capture. (ResMan: http://www.medresman.org.)
This study will share individual participant data (IPD) including patient characteristics, vital signs, laboratory examinations, imaging examinations, diagnosis, adverse events in hospital and long-term prognosis.