The Oxidative Stress, Inflammatory Markers, and Metabolomics Response to Exercise in Patients With COPD

NCT04117412 | Completed

• 1 other identifier: GO 18/1121-05
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The effect of different physical exercise protocols on inflammatory markers, antioxidant balance, and metabolomics has not been fully elucidated. Therefore, the purpose of this study is to investigate the responses of oxidative stress, inflammatory markers, and metabolomics to exercise.

Conditions

Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (4)

• Response of total work values to maximal exercise test, high intensity interval and continuous exercise

  Peak work rates will be determined using cycle ergometer. Maximal exercise test will be performed on the first day, high intensity interval and continuous exercise will be performed with one week intervals.

  Change from baseline to after maximal exercise test, high intensity interval, and continuous exercise, up to 3 weeks.

• The inflammatory markers response to maximal exercise test, high intensity interval and continuous exercise

  Blood samples will be collected before and after exercise and analyzed for the responses of IL-1, IL-6, TNF-α, sTNFr1. Maximal exercise test will be performed on the first day, high intensity interval and continuous exercise will be performed with one week intervals.

  Change from baseline to after maximal exercise test, high intensity interval, and continuous exercise, up to 3 weeks.

• The oxidative response to maximal exercise test, high intensity interval and continuous exercise

  Blood samples will be collected before and after exercise and analyzed for the responses of glutathione peroxidase, catalase, superoxide dismutase, glutathione, and total antioxidant status. Maximal exercise test will be performed on the first day, high intensity interval and continuous exercise will be performed with one week intervals.

  Change from baseline to after maximal exercise test, high intensity interval, and continuous exercise, up to 3 weeks.

• The metabolomics response (valine-leucine-isoleucine, alanine) to maximal exercise test, high intensity interval, and continuous exercise.

  Blood samples will be collected before and after exercise and analyzed for identification of metabolomics which change with exercise. Maximal exercise test will be performed on the first day, high intensity interval and continuous exercise will be performed with one week intervals.

  Change from baseline to after maximal exercise test, high intensity interval, and continuous exercise, up to 3 weeks.

Study Arms (1)

Patients with COPD

OTHER

Patients with COPD will undergo two different one bout of exercise training after maximal exercise test.

Other: Exercise

Interventions

Exercise OTHER

Same participants will undergo different one bout of exercise protocols

Patients with COPD

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of COPD (clinically stable)
• Being 40-80 years of age
• Able and willing to complete the informed consent process.

You may not qualify if:

• To have severe neuromuscular, musculoskeletal and rheumatic problems
• Unable to cooperate

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

Related Publications (1)

• Cakmak A, Nemutlu E, Yabanoglu-Ciftci S, Baysal I, Kocaaga E, Coplu L, Inal-Ince D. Metabolomic, oxidative, and inflammatory responses to acute exercise in chronic obstructive pulmonary disease. Heart Lung. 2023 May-Jun;59:52-60. doi: 10.1016/j.hrtlng.2023.01.011. Epub 2023 Jan 30.

  PMID: 36724589 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Exercise

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Deniz Inal-Ince, PhD

  Hacettepe University

  STUDY DIRECTOR

• Aslihan Cakmak, MSc

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Emirhan Nemutlu, PhD

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Samiye Yabanoglu-Ciftci, PhD

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Model Details: Same participants will undergo two different exercise protocols after maximal exercise test.

Study Record Dates

• First Submitted: September 5, 2019
• First Posted: October 7, 2019
• Study Start: March 15, 2019
• Primary Completion: March 15, 2021
• Study Completion: March 15, 2021
• Last Updated: January 13, 2023

Record last verified: 2023-01

Locations

TU (1)