Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease

NCT01561625 | Completed DMC

• 1 other identifier: SIM-COPD-20458
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD). Although resistance exercises increase strength and muscle mass in patients with COPD, the response to training appears to be suboptimal in these individuals. A dysregulation in the signaling pathways involved in the regulation of muscle mass could play an important role in this phenomenon. Hypothesis: Proteins involved in muscle mass regulation will be less activated in the quadriceps of patients with COPD following the acute bout of resistance training exercise compared to healthy age-matched controls.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD; exercise training

Outcome Measures

Primary Outcomes (1)

• Post-exercise signaling proteins phosphorylation level in the quadriceps of COPD patients and age-matched healthy controls

  Phosphorylation status of key proteins (Akt, p70, mTOR, p38, JNK, ERK) will be lesser modulated in the quadriceps of patients with COPD compare to healthy controls. The phosphorylated as well as the total protein levels will be measured by western blot. The data will be presented as arbitrary units and compared with values obtained in healthy age-matched healthy controls.

  2 hours post-exercise

Interventions

exercise OTHER

resistance training exercise, 1 session, 3 exercises, 80% of max

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male
• COPD with an FEV1 of under 60% of predicted
• non-smoker
• Between 50 and 75 years old

You may not qualify if:

• All inflammatory disease (HIV, Cancer, renal and cardiac deficiency)
• Hormonal dysregulation
• Inferior limb pathology
• Neuromuscular pathology
• History of tabacco or alcool abuse
• Oxygen dependent
• Recent exacerbation (2 months) of the symptoms of COPD

Sponsors & Collaborators

• Laval University: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

IUCPQ

Québec, Quebec, G1V 4G5, Canada

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Exercise

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• François Maltais, MD

  Laval University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Étudiant au doctorat

Study Record Dates

• First Submitted: March 20, 2012
• First Posted: March 23, 2012
• Study Start: October 1, 2009
• Primary Completion: April 1, 2013
• Study Completion: April 1, 2013
• Last Updated: May 7, 2013

Record last verified: 2013-05

Locations

CA (1)