Mitochondrial Remodeling After Exercise

NCT04103424 | Completed

• 1 other identifier: IRB-2019-0124
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Conditions

Overweight and Obesity; Insulin Resistance; Metabolic Disease; Mitochondrial Metabolism; Sedentary Lifestyle

Outcome Measures

Primary Outcomes (1)

• Change in skeletal muscle mitochondrial protein degradation peptide products

  Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.

  After 2-weeks of exercise training compared with before training.

Study Arms (2)

Pre-training Metabolic Study Visit

NO INTERVENTION

Participants will first complete a pre-training metabolic study visit.

Post-training Metabolic Study Visit

EXPERIMENTAL

Participants will complete a second, identical metabolic study visit following 2-weeks of exercise training.

Behavioral: Short-term Exercise Training

Interventions

Short-term Exercise Training BEHAVIORAL

Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Post-training Metabolic Study Visit

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-45 years
• Body mass index (BMI) 18-45 kg/m2
• Sedentary (\<1 hour of planned exercise per week)

You may not qualify if:

• Regular exercise (\>1 hour of planned exercise per week)
• Smoking, tobacco or nicotine use within the last 1-year
• Fasting glucose \>126mg/dL
• Hypertension (systolic pressure \>140 mmHg or diastolic pressure \>90 mmHg)
• Chronic metabolic or cardiovascular health conditions
• Pregnant, nursing, irregular menses or post-menopausal
• Lidocaine allergy
• Certain medications
• Physical limitations that prevent safe or successful exercise completion
• Diminished capacity for consent

Sponsors & Collaborators

• Oregon State University: lead

Study Sites (1)

Oregon State University

Corvallis, Oregon, 97331, United States

Location

MeSH Terms

Conditions

Overweight; Obesity; Insulin Resistance; Metabolic Diseases; Sedentary Behavior

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Behavior

Study Officials

• Sean Newsom, PhD

  Oregon State University

  PRINCIPAL INVESTIGATOR

• Matthew Robinson, PhD

  Oregon State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be asked to complete 2 screening visits to determine eligibility. If participants remain eligible, they will be asked to complete 2 metabolic study visits, 1 before and 1 after 2 weeks of supervised exercise training on a stationary bike.

Study Record Dates

• First Submitted: August 23, 2019
• First Posted: September 25, 2019
• Study Start: August 23, 2019
• Primary Completion: November 25, 2020
• Study Completion: December 3, 2022
• Last Updated: February 13, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)